Malformaciones congénitas en hijos de madres con diabetes gestacional

Herrera, Jesús; Huidobro, Moira García; Ovalle, Lucía Cifuentes

doi:10.4067/s0034-98872005000500006

Cited by 18 publications

(7 citation statements)

References 8 publications

(6 reference statements)

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“…The result of the present study found that mothers with diabetes Mellitus were 9 times at greater risk of having children with congenital malformations. This in line with the study done in University of Chile Clinical Hospital reporting gestational diabetes associated with CM [25]. Hence, more attention should be taken to the control of diabetes especially during the first trimester of pregnancy.…”

Section: Discussionsupporting

confidence: 86%

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

2018

KJAR

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Congenital anomalies comprise a wide range of abnormalities in body structure or function that are present at birth and are of prenatal origin. These are defined as structural changes that have significant medical, social or cosmetic consequences for the affected individual, and typically require medical intervention. According to our Knowledge, research is scarce on these conditions in Sulaimaniyah city. Therefore, the current study was conducted to investigate potential risk factors for congenital anomalies. A case-control study was carried out from March to August 2017 involving 400 children (200 cases and 200 controls) aged 0-5 years. Required data were obtained on the risk factors through face to face interviews with mothers of cases and controls. The data were using descriptive statistical methods, Chi-square and Logistic Regression using STATA 11, calculating odds ratios and condensing P value less than 0.05 as statistically significant. The mean age of the children was 1.9 years and age of their mothers at the time of pregnancy was 28 years. Congenital heart anomalies were the commonest type accounting for 27.5%. Significant risk factors for congenital anomalies were family history (OR=2.24, P= 0.007), maternal obesity (OR= 2.26, P= 0.001), mothers age over 30 (OR=2.78, P= 0.002) and mothers not using folic acid during pregnancy (OR=2.12, P= 0.0007). In general, in order to control and prevent the cases of CM, it is important to provide health education and policies to reduce environmental and maternal risk factors. Further, studies with larger sample size are needed to investigate incidence and risk factors of congenital anomalies.

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Section: Discussionsupporting

confidence: 86%

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

2018

KJAR

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“…Em uma revisão da literatura sobre a mortalidade perinatal no Brasil, destacase que a maioria dos óbitos é considerada evitável, e as principais falhas apontadas se encontram na qualidade da assistência ao pré-natal, ao parto e à assistência neonatal 28 . Além das complicações na mulher, o diabetes gestacional e a pré-eclâmpsia são doenças relacionadas à máformação congênita, aos problemas respiratórios no concepto e ao crescimento intra-uterino restrito, por exemplo 29,30 . Nesse sentido, destacase a importância do controle das morbidades maternas com a realização de um pré-natal de qualidade.…”

Section: Or Bruta (Ic90%)unclassified

Gravidez na adolescência e outros fatores de risco para mortalidade fetal e infantil no Município do Rio de Janeiro, Brasil

2010

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This article analyzes teenage pregnancy and other risk factors for fetal and infant mortality in the city of Rio de Janeiro, Brazil. The study included a sample of births in Rio de Janeiro, and exposure variables were organized hierarchically. For fetal death, the results showed the protective effect of adequate prenatal care, while maternal morbidity increased the risk. For neonatal death, adequate prenatal care and female gender in the newborn were protective factors, while black or brown maternal skin color, history of stillbirth, maternal morbidity, and physical aggression during the index pregnancy increased the risk. Low birth weight and prematurity were corroborated as determinants of fetal and neonatal death. Risk of post-neonatal death was highest with increased parity, intra-gestational morbidity, and low birth weight. Teenage pregnancy itself was an independent factor for post-neonatal death. The findings reaffirm the relevance of social and health policies targeting adolescents, as well as improvements in prenatal care.

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“…Periconceptional folic acid supplementation has been shown to reduce significantly the first occurrence and recurrence of neural tube defects (NTDs) in humans, pointing to its role in the pathogenesis of this condition. However, in experimental animals, a variety of environmental agents have been implicated, including ethanol (10,28) , inhibition of cholesterol synthesis (6,10) , retinoic acid (45) , vitamin A (23) , hyperglycemia (12,43) , hypoxia (2,13) , ionizing radiation/ hyperthermia (30) and nicotine (18,24) .…”

Section: Introductionmentioning

confidence: 99%

“…It is well recognized that babies born to diabetic mothers are 3 to 4 times more prone to present congenital anomalies than is the general population (21,34) . Such anomalies have been correlated with inefficient blood glucose control (34,43) which may induce diabetic embryopathy, which encompasses NTDs and other system defects (12,16) .…”

Section: Introductionmentioning

confidence: 99%

Effect of alloxan-induced diabetes mellitus and ethanol on pregnancy outcome in mice

Peres

Ribeiro

Gutierrez

et al. 2009

J. Bras. Patol. Med. Lab.

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Introduction and objectives: To investigate the effects of ethanol, diabetes mellitus and the combination of both on mouse fetuses. Methods: We used 24 female Swiss mice, dividing them into four groups of 6 each: control (C), ethanol (E), diabetes (D) (blood glucose > 200 mg/dL) and diabetes + ethanol (DE). Diabetes was induced by alloxan (40 mg/kg) on day 7 of pregnancy. Groups E and DE received 4 g/kg of 25% v/v ethanol intraperitoneally, whereas groups C and D received saline. On day 18, all fetuses were harvested. Results: In group DE the following anomalies were found: exencephaly, situs inversus totalis, situs inversus partialis, eyelid skin tag and one animal from group E had pulmonary artery hypoplasia. Ethanol administration partially reverted diabetes-fetal resorption caused by diabetes, yet it induced late fetal death. Both diabetes and ethanol reduced placental diameter and increased its weight. Ethanol had more effect on fetal length in males than in females, however, such bias was not found for diabetes. Ethanol prevented diabetes-induced tail shortening in both genders. Conclusions: These results show that, although ethanol might improve energy metabolism in early gestation, it causes cell damage that leads to cardiovascular, limb and neural tube defects, late fetal death and reduced placental size.

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Malformaciones congénitas en hijos de madres con diabetes gestacional

Abstract: Pregnant women with pre-existing or gestational diabetes have a higher risk of giving birth a child with malformations.

Cited by 18 publications

References 8 publications

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

Gravidez na adolescência e outros fatores de risco para mortalidade fetal e infantil no Município do Rio de Janeiro, Brasil

Effect of alloxan-induced diabetes mellitus and ethanol on pregnancy outcome in mice

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