Malformation in coccolithophores in low pH waters: evidences from the eastern Arabian Sea

Shetye, S.R.; Gazi, Sahina; Manglavil, Arundhathy; Shenoy, Damodar M.; Kurian, Siby; Pratihary, Anil; Shirodkar, Gayatri; Mohan, Rahul; Dias, Albertina; Naik, Hema; Gauns, Mangesh; Nandakumar, K.; Borker, Sidhesh G.

doi:10.1007/s11356-023-25249-5

Cited by 2 publications

(2 citation statements)

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“…In p H-negative control groups corresponding to 46.72, 154.18, and 467.2 μM of PFOA acid (pH = 5.58, 4.24, and 3.36, respectively; Table S3), the mortality of zebrafish larvae increased to 16.4%, 20.2%, and 54.2% (Figure A). Acidic water is known to be highly detrimental to the growth and viability of aquatic organisms. , The mortality percentage of PFOA acid groups was significantly higher than that of the pH control groups at 154.18 and 467.2 μM. Thus, the inherent toxicity of PFOA acid was assumed to be the predominant contributor to developmental toxicity outcomes, whereas the embryogenic impacts of acidic culturing media became increasingly severe as pH decreased.…”

Section: Resultsmentioning

confidence: 98%

“…Acidic water is known to be highly detrimental to the growth and viability of aquatic organisms. 40,41 The mortality percentage of PFOA acid groups was significantly higher than that of the pH control groups at 154.18 and 467.2 μM. Thus, the inherent toxicity of PFOA acid was assumed to be the predominant contributor to developmental toxicity outcomes, whereas the embryogenic impacts of acidic culturing media became increasingly severe as pH decreased.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Significant Variability in the Developmental Toxicity of Representative Perfluoroalkyl Acids as a Function of Chemical Speciation

Bai,

Wang,

et al. 2023

Environ. Sci. Technol.

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Current toxicological data of perfluoroalkyl acids (PFAAs) are disparate under similar exposure scenarios. To find the cause of the conflicting data, this study examined the influence of chemical speciation on the toxicity of representative PFAAs, including perfluorooctanoic acid (PFOA), perfluorobutane carboxylic acid (PFBA), and perfluorobutanesulfonic acid (PFBS). Zebrafish embryos were acutely exposed to PFAA, PFAA salt, and a pH-negative control, after which the developmental impairment and mechanisms were explored. The results showed that PFAAs were generally more toxic than the corresponding pH control, indicating that the embryonic toxicity of PFAAs was mainly caused by the pollutants themselves. In contrast to the high toxicity of PFAAs, PFAA salts only exhibited mild hazards to zebrafish embryos. Fingerprinting the changes along the thyroidal axis demonstrated distinct modes of endocrine disruption for PFAAs and PFAA salts. Furthermore, biolayer interferometry monitoring found that PFOA and PFBS acids bound more strongly with albumin proteins than did their salts. Accordingly, the acid of PFAAs accumulated significantly higher concentrations than their salt counterparts. The present findings highlight the importance of chemical forms to the outcome of developmental toxicity, calling for the discriminative risk assessment and management of PFAAs and salts.

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Section: Resultsmentioning

confidence: 98%

Section: ■ Results and Discussionmentioning

confidence: 99%