Malignancy in patients with sarcoidosis

Kobak, Şenol; Yıldız, Fidan; Semiz, Hüseyin; Orman, Mehmet

doi:10.1016/j.reuma.2019.04.003

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…Sarcoidosis and malignancy have been associated in some case series including patients diagnosed with cancer directly before or after the diagnosis of sarcoidosis. However, this relationship remains controversial and may be incidental [20][21][22][23][24][25]. Hypothesis of a possible association and a possible increased risk of cancer include the chronic inflammation, the immune system dysregulation and immunosuppressive medication of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic challenge of coexistent sarcoidosis and thyroid cancer – a retrospective study

et al. 2021

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Background Sarcoid lesions may mimic metastatic disease or recurrence in thyroid cancer (TC) patients as both diseases may affect the lungs and lymph nodes. We present the first study to systematically evaluate the clinical course of patients with (TC) after adjuvant radioactive iodine therapy (RIT) and concomitant sarcoidosis of the lung or the lymph nodes. Methods We screened 3285 patients and retrospectively identified 16 patients with TC (11 papillary thyroid cancer (PTC), 3 follicular thyroid cancer (FTC), 1 oncocytic PTC, 1 oncocytic FTC) and coexisting sarcoidosis of the lung and/or the lymph nodes treated at our institute. All patients had undergone thyroidectomy and initial adjuvant RIT. Challenges in diagnosing and the management of these patients were evaluated during long term follow-up (median 4.9 years (0.8–15.0 years)). Results Median age at first diagnosis of TC was 50.1 years (33.0–71.5 years) and of sarcoidosis 39.4 years (18.0–63.9 years). During follow-up, physicians were able to differentiate between SA and persistent or recurrent TC in 10 of 16 patients (63%). Diagnosis was complicated by initial negative thyroglobulin (Tg), positive Tg antibodies and non-specific imaging findings. Histopathology can reliably distinguish between SA and TC in patients with one suspicious lesion. Conclusion Physicians should be aware of the rare coexistence of sarcoidosis and TC. Lymphadenopathy and pulmonary lesions could be metastases, sarcoidosis or even a mix of both. Therefore, this rare patient group should receive a thorough work up including histopathological clarification and, if necessary, separately for each lesion.

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Section: Discussionmentioning

confidence: 99%

The diagnostic challenge of coexistent sarcoidosis and thyroid cancer – a retrospective study

et al. 2021

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“…Systemic treatment of sarcoidosis was necessary in half of these cases. The authors suggest that sarcoidosis following solid cancer should be considered as a protective factor against a relapse of cancer due to the low rate of cancer recurrence in this population [126,127]. In any case, the relationship between sarcoidosis and cancer as well as the impact of breast cancer treatment on the pathophysiology of sarcoidosis have yet to be completely elucidated.…”

Section: Sarcoidosismentioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

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Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

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“…The underlying mechanism between the coexisting of sarcoidosis and malignancy is still unclear [20].…”

Section: Pathology Of Sarcoidosis Association With Other Disorders/malignancymentioning

confidence: 99%

Sarcoidosis: Various Presentations, Coexisting Diseases and Malignancies

Gaddam¹,

Ojinnaka²,

Ahmed³

et al. 2021

Cureus

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Sarcoidosis is a rare, chronic inflammatory disease with a characteristic non-caseating granuloma formation. It affects women more than men. The lung is the most commonly affected organ, however, extrapulmonary involvement is also seen. Sarcoidosis can affect any organ or tissue and can also involve multiple organs simultaneously. As a disease, it shares clinical symptoms with a variety of autoimmune, non-autoimmune disorders and malignancies. Not only it mimics clinically, but it also coexists with these diseases, posing a significant diagnostic challenge. During this literature review, we obtained data from the previously published PubMed articles within the last five years and reviewed the possible etiological association and clinical coexistence between sarcoidosis and other diseases/malignancies. We aimed to determine the common clinical manifestations, various complex presentations of sarcoidosis and pathophysiological considerations for the association, and to emphasize the link with other diseases, particularly thyroid disorders/malignancies. Physicians should be aware of these associated diseases and should always make a clinical suspicion when confronting a sarcoidosis patient. Thus, a comprehensive diagnostic evaluation for these associated conditions ought to be done in sarcoidosis patients to avoid any delay in the curative treatment for these coexisting diseases and to prevent substandard outcomes.

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Malignancy in patients with sarcoidosis

Cited by 6 publications

References 7 publications

The diagnostic challenge of coexistent sarcoidosis and thyroid cancer – a retrospective study

The diagnostic challenge of coexistent sarcoidosis and thyroid cancer – a retrospective study

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Sarcoidosis: Various Presentations, Coexisting Diseases and Malignancies

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