Malignancy in three medieval Polish osteological collections

Siek, Thomas; Rando, Carolyn; Spinek, Anna; Cieślik, Agata; Waldron, Tony

doi:10.1016/j.jasrep.2021.103246

Cited by 1 publication

(1 citation statement)

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“…For example, Danforth and colleagues [ 31 ] consider other diagnoses unlikely rather than excluded. Pechenkina and colleagues [ 62 ] find angioma more likely than meningioma in their case, and angioma as well as unidentified tumor are considered as alternatives in a medieval case from Poland [ 63 , 64 ]. Ortner and Putschar [ 54 ] suggest that the lesion observed in their case study might also be an eosinophilic granuloma, carcinoma, or angioma.…”

Section: Data Collection and Analysismentioning

confidence: 99%

Meningiomas in Ancient Human Populations

Cook

Danforth

2022

Cancers

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Meningiomas are the most common tumor of the central nervous system and can result in skeletal manifestations, including hyperostosis of the adjacent cranial bone, enostoses, depressions, and enhanced vascular impressions. However, their identification in the paleopathological literature has been rare and few cases have received broad acceptance of the diagnosis. A review of the literature identified some 43 cases in which individuals were argued to have suffered from meningiomas. Most were seen in older individuals but were more likely to affect males. Eleven individuals exhibited hyperostosis, the most easily recognized indicator, usually located on the parietal bone; the hyperostotic region averaged 8 cm in diameter and 3.0 cm in height. Seven displayed lytic lesions with areas much smaller in size than the hyperostosis, and many had vascular changes. The other cases had indicators that varied greatly in terms of location and expression and included both sclerotic lesions and hollow areas. Several authors also suggested other possible causes of the lesions. The findings reflect the non-pathognomonic nature of the effects of meningiomas. However, given their likely frequency and potentially severe effects in ancient people, it is argued that they should be taken into consideration more frequently when performing differential diagnoses.

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Section: Data Collection and Analysismentioning

confidence: 99%