Malignancy of a cystadenolymphoma of the parotid gland

Abstract

The authors describe malignant degeneration of the epithelial component of a cystadenolymphoma (CAL) of the parotid gland in a 79-year-old man. This development of carcinoma in CAL is a very rare occurrence, with only eight cases described thus far in the literature.

US of the Major Salivary Glands: Anatomy and Spatial Relationships, Pathologic Conditions, and Pitfalls

“…In about 10%-60% of cases, tumors may occur bilaterally or multifocally, sometimes metachronously, growing and manifesting clinically at different times (3,68,77,78). Sporadically, the epithelial component of Warthin tumor may undergo malignant transformation (68,79).…”

Mucoepidermoid carcinoma arising in Warthin's tumour of the parotid gland: report of two cases with histopathological, ultrastructural and immunohistochemical studies

“…Moreover, some of the cases published as carcinoma arising in WT have not been considered convincing. Carcinomatous components include squamous cell carcinoma, 7,10,13,15,17,20,25 oncocytic carcinoma, 16,19,21,23 adenocarcinoma, 6,8,18,22,24 undifferentiated carcinoma, 9,12,14 and mucoepidermoid carcinoma (MEC). 11,26,27 Only three cases has been reported so far regarding to MEC.…”

Molecular assessment of allelic loss in Warthin tumors

“…2 In very rare instances, malignancy can arise in conjunction with a Warthin's tumor, either in the form of lymphoma or carcinoma. [12][13][14] It remains controversial whether these are merely synchronous lesions, or are related pathogenetically. The extremely low rate of malignancy, as compared to that seen in pleomorphic adenoma (carcinoma ex pleomorphic adenoma) suggests that the tumors are synchronous rather than clonally related.…”