Malignancy of the Kidney, Survey of 195 Cases

Graham, Albert P.

doi:10.1016/s0022-5347(17)69512-0

Cited by 54 publications

(9 citation statements)

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“…RCC metastases account for 7.1% of these lesions [2]. Graham reported that only 4% of RCCs metastasized to the small intestine [5]. Solitary duodenal metastasis from RCC is exceedingly rare and most frequently involves the periampullary region or the duodenal bulb [6, 7].…”

Section: Discussionmentioning

confidence: 99%

Duodenal Bleeding from Metastatic Renal Cell Carcinoma

Rustagi

Rangasamy²,

Versland³

2011

Case Rep Gastroenterol

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Massive upper gastrointestinal bleeding due to malignancy is relatively uncommon and the duodenum is the least frequently involved site. Duodenal metastasis is rare in renal cell carcinoma (RCC) and early detection, especially in case of a solitary mass, helps in planning further therapy. We report a case of intractable upper gastrointestinal bleeding from metastatic RCC to the duodenum. The patient presented with melena and anemia, 13 years after nephrectomy for RCC. On esophagogastroduodenoscopy, a submucosal mass was noted in the duodenum, biopsies of which revealed metastatic RCC. In conclusion, metastasis from RCC should be considered in nephrectomized patients presenting with gastrointestinal symptoms and a complete evaluation, especially endoscopic examination followed by biopsy, is suggested.

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Section: Discussionmentioning

confidence: 99%

Duodenal Bleeding from Metastatic Renal Cell Carcinoma

Rustagi

Rangasamy²,

Versland³

2011

Case Rep Gastroenterol

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“…A series published by Graham [13] stated only 4% of RCC metastasize to the small intestine, while a more recent Mayo Clinic 50-year review found only 3 cases of small intestinal metastasis in RCC, which did not include cases of direct tumour extension [14]. …”

Section: Discussionmentioning

confidence: 99%

“…These usually manifest as gastrointestinal bleeding, although cases of small bowel intussusception are described [16-19]. Direct invasion of the duodenum from pancreatic metastases is also reported [13,20-22]. …”

Section: Discussionmentioning

confidence: 99%

Metastases from renal cell carcinoma presenting as gastrointestinal bleeding: two case reports and a review of the literature

et al. 2007

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Background: Bleeding from small bowel neoplasms account for 1-4% of cases of upper gastrointestinal haemorrhage. Renal cell carcinoma constitutes 3% of all adult malignancies and often presents insidiously. Consequently 25-30% of patients have metastases at the time of diagnosis. Gastrointestinal bleeding from renal cell carcinoma metastases is an uncommon and under-recognised manifestation of this disease.

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“…However, only 4% of RCCs metastasize to the small intestine, and duodenal metastasis occurs less frequently than metastasis to the jejunum and ileum [2]. RCC metastasis to the duodenum is also a rare event, accounting for 7.1% of all small bowel metastases [3].…”

Section: Introductionmentioning

confidence: 99%

Repeated Pancreatectomy for Metachronous Duodenal and Pancreatic Metastases of Renal Cell Carcinoma

Hata¹,

Sakata²,

Aoki³

et al. 2013

Case Rep Gastroenterol

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A 50-year-old woman had undergone left nephrectomy for renal cell carcinoma 13 years previously. Ten years later, a solitary metastatic tumor had been detected in the pancreatic tail and she had undergone subsequent resection of the pancreatic tail and spleen. Three years after surgery, she was admitted to our hospital for severe anemia resulting from gastrointestinal tract bleeding. Esophagogastroduodenoscopy revealed a 3-cm solid tumor at the oral side of the papilla of Vater. Histology of the bioptic duodenal tissue revealed inflammatory granulation without malignancy. Computed tomography showed a well-contrasted hypervascular tumor in the descending portion of the duodenum. We diagnosed the patient with metachronous duodenal metastasis of renal cell carcinoma and performed a pancreaticoduodenectomy. An ulcerated polypoid mass was detected at the oral side of the papilla of Vater. Histology revealed clear cell carcinoma coated by granulation tissue across the surface of the tumor. Immunohistology demonstrated that the cells were positive for vimentin, CD10 and epithelial membrane antigen and negative for CK7. After a repeated pancreatectomy, the patient had no symptoms of gastrointestinal bleeding and maintained good glucose tolerance without insulin therapy because the remnant pancreas functioned well. In conclusion, for the diagnosis of patients who have previously undergone nephrectomy and present with gastrointestinal bleeding, the possibility of metastasis to the gastrointestinal tract, including the duodenum, should be considered. With respect to surgical treatment, the pancreas should be minimally resected to maintain a free surgical margin during the first surgery taking into account further metachronous metastasis to the duodenum and pancreas.

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Malignancy of the Kidney, Survey of 195 Cases

Cited by 54 publications

References 1 publication

Duodenal Bleeding from Metastatic Renal Cell Carcinoma

Duodenal Bleeding from Metastatic Renal Cell Carcinoma

Metastases from renal cell carcinoma presenting as gastrointestinal bleeding: two case reports and a review of the literature

Repeated Pancreatectomy for Metachronous Duodenal and Pancreatic Metastases of Renal Cell Carcinoma

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