Malignant acrospiroma of chest and abdominal wall treated with chemotherapy

Bandyopadhyay, Anis; Das, Moumita; Jana, Sukumar; Das, Anuradha

doi:10.4103/0019-5154.110849

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…The use of second-line sunitinib was associated with an 8-month progression-free survival in one patient [22]. The role of radiotherapy appears to be more established [4, 12, 13]. In one report of 3 patients who received adjuvant radiotherapy, 2 patients remained disease free at 27 and 35 months, respectively, after the completion of treatment; the third died of rapidly progressive systemic disease [23].…”

Section: Discussionmentioning

confidence: 99%

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Malignant acrospiroma: a case report in the era of next generation sequencing

2017

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BackgroundMalignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.Case presentationWe herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.ConclusionTo the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.

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Section: Discussionmentioning

confidence: 99%

“…The efficacy of adjuvant chemotherapy is controversial. Adjuvant radiotherapy has been shown successful in some cases [4, 12, 13]. With the advent of targeted therapy, genetic profiling is becoming a more attractive tool.…”

Section: Introductionmentioning

confidence: 99%

Malignant acrospiroma: a case report in the era of next generation sequencing

2017

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“…Various case reports and case series have reported on the use of a multitude of drugs in various sweat gland carcinomas including cyclophosphamide and doxorubicin, bleomycin, cisplatin, mitomycin C, with partial response and a median duration of response of 4 to 16 months. [13][14][15][16] There are also isolated reports of response to taxanes (docetaxel and paclitaxel). [17] Analyzing all the available literature, we conclude that wide local excision is the treatment of choice for these rare skin appendage tumors when localized, while adjuvant radiotherapy may provide some additional benefit in local control.…”

Section: Discussionmentioning

confidence: 99%

Malignant eccrine acrospiroma with nodal and bone metastasis

Wani¹,

Aziz²,

Mir³

et al. 2016

JCMT

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Acrospiromas are cutaneous tumors of sweat duct differentiation. Although various eccrine sweat gland tumours including benign acrospiroma are widely reviewed, malignant acrospiroma is rarely reported. Clinically, they resemble other cutaneous lesions and the primary treatment is wide local excision with or without lymph node dissection. The efficacy of adjuvant chemotherapy and radiation therapy requires further investigation.

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Hidradenocarcinoma of the Chest With Axillary Lymph Node Metastasis: Report of 2 Cases and Systematic Literature Review of a Breast Cancer Mimicker

Fortarezza,

Maggioni,

Colagrande

et al. 2024

The American Journal of Dermatopathology

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Hidradenocarcinoma (HAC) is a rare malignant neoplasm originating from eccrine sweat glands, often presenting diagnostic challenges because of its resemblance to other malignancies, particularly breast cancer when occurring in the chest region. This report describes 2 cases of HAC with axillary lymph node metastasis, both initially misinterpreted clinically. The first case involved a 63-year-old woman with a sternal mass, near the right breast, initially suspected to be a sebaceous cyst. Histologic examination revealed a solid-cystic epithelial tumor with features suggestive of HAC, confirmed by immunohistochemical analysis. The second case concerned an 81-year-old woman with a subcutaneous growth in the sternal area, also diagnosed as HAC after histopathologic and immunohistochemical assessment. Both cases demonstrated strong estrogen receptor positivity, leading to the recommendation of hormonal therapy. A systematic review of the literature identified 21 similar cases of HAC in the chest wall, highlighting the diagnostic complexities and the potential for these tumors to mimic breast carcinoma. This review underscores the need for careful histologic and immunohistochemical evaluation to differentiate HAC from other malignancies, particularly in the breast region. Given the rare and the potential aggressive nature of HAC, early and accurate diagnosis is crucial for guiding appropriate therapeutic strategies and improving patient outcomes.

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Malignant acrospiroma of chest and abdominal wall treated with chemotherapy

Cited by 6 publications

References 11 publications

Malignant acrospiroma: a case report in the era of next generation sequencing

Malignant acrospiroma: a case report in the era of next generation sequencing

Malignant eccrine acrospiroma with nodal and bone metastasis

Hidradenocarcinoma of the Chest With Axillary Lymph Node Metastasis: Report of 2 Cases and Systematic Literature Review of a Breast Cancer Mimicker

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