Malignant (acute) myelosclerosis ‐ a clinical and pathological study in 6 patients

Thiele, Jürgen; Krech, Rainer; Vykoupil, K. F.; Georgii, A.

doi:10.1111/j.1600-0609.1984.tb02217.x

Cited by 21 publications

(2 citation statements)

References 41 publications

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“…Idiopathic myelofibrosis was defined by unexplained excessive accumulation of connective tissue in the bone marrow. Patients with chronic IMF were distinguished by leucoerythroblastic anaemia, anisoand tear-drop poikilocytosis and splenomegaly ( l), whereas patients with acute myelofibrosis were characterized by pancytopenia, no enlargement of the spleen on clinical examination, severe myelofibrosis with an excess of megakaryocytes and a rapidly fatal clinical course (2)(3)(4). 114 bone marrow biopsies were evaluated.…”

Section: -27)mentioning

confidence: 99%

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A sequential histological study of bone marrow fibrosis in idiopathic myelofibrosis

Hasselbalch

Lisse

1991

European J of Haematology

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A sequential histological study of bone marrow biopsies from 36 patients with idiopathic myelofibrosis was performed to investigate the accumulation of connective tissue in the bone marrow during the course of the disease and the influence of therapy on this process. The degree of bone marrow fibrosis was graded semiquantitatively from 0 (normal) to + 5 (extensive collagen fibrosis and ostemyelosclerosis). The median interval between the first and final biopsy was 25 months (range 3 to 103) in patients with chronic idiopathic myelofibrosis and 2 months (range 1 to 14) in patients with a syndrome of acute myelofibrosis. In most patients with chronic IMF the bone marrow fibrosis remained unchanged. Regression of bone marrow fibrosis in 9 patients with chronic IMF was associated with immunosuppressive/‐cytotoxic treatment or splenectomy. Severe bone marrow fibrosis completely resolved during intensive chemotherapy of a patient with acute myelofibrosis. No relationship existed between spleen size and the degree of bone marrow fibrosis.

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Section: -27)mentioning

confidence: 99%

“…The purposes of the present investigation were to study the accumulation of bone marrow collagen in (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

A sequential histological study of bone marrow fibrosis in idiopathic myelofibrosis

Hasselbalch

Lisse

1991

European J of Haematology

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Idiopathic myelofibrosis: A clinical study of 80 patients

Hasselbalch

1990

American J Hematol

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A series of 122 consecutive patients with bone marrow fibrosis initially referred or categorized as idiopathic myelofibrosis is described. After a clinical and pathological review 14 patients were classified as postpolycythaemic myelofibrosis and 7 patients as a transitional myeloproliferative disorder. In 13 patients a diagnosis of hairy cell leukaemia was made, 3 patients had malignant lymphoma, 2 had malignant histiocytosis, and 1 patient had systemic lupus erythematosus with myelofibrosis. Two patients were excluded for further analysis owing to insufficient data. In the remaining 80 patients a diagnosis of idiopathic myelofibrosis was made. The clinical and laboratory findings in this series of patients are presented and compared to those in previous series. Infectious, cardiovascular, thromboembolic, and haemorrhagic complications were frequent, being recorded in 63%, 50%, 40%, and 33% of the patients, respectively. Various autoimmune phenomena were found in a proportion of the patients, but none had clinical evidence of connective tissue disease. Fifteen patients (19%) had a syndrome of acute myelofibrosis. The diagnostic criteria for this disease entity and its place within the spectrum of myeloproliferative disorders are discussed. In the present series acute myelofibrosis was found to encompass various transitional stages toward the evolution of acute leukaemia. It is proposed that acute or malignant myelofibrosis is considered as an acute variant of idiopathic myelofibrosis. Within this syndrome the acute variant seems to be far more common than previously recognized, which may also explain the marked clinical heterogeneity of the myelofibrosis/osteomyelosclerosis syndrome in this and most previous series.

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Rare Hematological Malignancies

Ansell

2008

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Malignant (acute) myelosclerosis ‐ a clinical and pathological study in 6 patients

Cited by 21 publications

References 41 publications

A sequential histological study of bone marrow fibrosis in idiopathic myelofibrosis

A sequential histological study of bone marrow fibrosis in idiopathic myelofibrosis

Idiopathic myelofibrosis: A clinical study of 80 patients

Rare Hematological Malignancies

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