Malignant adenomyoepithelioma of the breast with matrix production may be compatible with one variant form of matrix-producing carcinoma: A case report

Oka, Kuniyuki; Sando, Norimasa; Moriya, Takuya; Yatabe, Yasushi

doi:10.1016/j.prp.2007.04.004

Cited by 17 publications

(13 citation statements)

References 17 publications

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“…Metaplastic carcinomas developing within AME are not uncommon, the most frequent being the spindle-cell variant of squamous carcinoma (figure 11), acantholytic variant of squamous carcinoma, low-grade adenosquamous carcinoma94 95 (figure 12) and mucoepidermoid carcinoma. The spindle and clear-cell cell variants of malignant myoepithelioma68 89 96 and metaplastic carcinoma with matrix production showing heterologous differentiation to chondrosarcoma and osteosarcoma can also be seen82 97 98 (figures 13 and 14). The presence of an identifiable low-grade component of AME is required for a diagnosis of malignant AME transformed to matrix-producing carcinoma 82 99.…”

Section: Malignant Amementioning

confidence: 99%

“…The spindle and clear-cell cell variants of malignant myoepithelioma68 89 96 and metaplastic carcinoma with matrix production showing heterologous differentiation to chondrosarcoma and osteosarcoma can also be seen82 97 98 (figures 13 and 14). The presence of an identifiable low-grade component of AME is required for a diagnosis of malignant AME transformed to matrix-producing carcinoma 82 99. Similarly, if the high-grade malignant component shows predominantly myoepithelial differentiation, identification of a low-grade component of AME is required in order to separate it from true malignant myoepithelioma.…”

Section: Malignant Amementioning

confidence: 99%

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Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Hayes¹

2011

J Clin Pathol

131

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This review describes the classification, clinical presentation, pathological features and clinical behaviour of adenomyoepithelioma (AME) of the breast. It is based on an extensive review of the literature and study of a collection of cases built up over a 17-year period at the British Columbia Cancer Agency. The diversity of the morphology encountered in both benign and malignant AME is described. The behaviour of malignant AME seems to be related to the grade of the malignant component.

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Section: Malignant Amementioning

confidence: 99%

Section: Malignant Amementioning

confidence: 99%

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Hayes¹

2011

J Clin Pathol

131

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“…showed a basal-like immunophenotype (ER-, HER2-, EGFR + and/or CK5/6 +) in 59 out of 65 cases of metaplastic breast cancer that produces stromal matrix that is an epithelial carcinoma with areas of mesenchymal differentiation [17]. Futhermore, a case of malignant adenomyoepithelioma of the breast that produces stromal matrix was described with immunohistochemical profile of myoepithelial differentiation (S100 e maspin positive) but not basal-like (CK14-negative) in the metaplastic component [18]. The presence of neoplastic components with an intermediate epithelial-mesenchymal differentiation in biphasic tumors of mammary gland suggests that these lesions can originate from mammarian stem cells with the potential to differentiate themselves into epithelial or into mesenchymal-myoepithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Breast adenomyoepithelioma: a case report with malignant proliferation of epithelial and myoepithelial elements

et al. 2013

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BackgroundBreast adenomyoepithelioma is an unusual tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells. Most breast adenomyoepitheliomas are considered to be benign or to have a low-grade malignant potential, characterized by propensity for local recurrence. Malignant changes arising in this lesion are extremely rare and may involve one or both cellular components.Case reportWe discuss a case of a 60 year-old woman who began to experience pain in her right breast in January 2009. Breast ultrasound and mammography were performed showing a rounded, hypoechoic solid lesion with ill-defined margins in the right inner-inferior quadrant, suspicious of malignancy. Quadrantectomy of the inner-inferior quadrant of the right breast with sampling of ipsilateral axillary lymph nodes was performed. The histological analysis confirmed the diagnosis of adenomyoepithelioma with focal malignant change of the epithelial component, associated with high-grade malignant myoepithelial change. The patient was treated with adjuvant radiotherapy and her right breast received a dose of Gy 50 with a boost of Gy 10 to the tumor bed. At present, the patient shows no sign of tumor recurrence.ConclusionBreast malignant adenomyoepithelioma is a rare tumor which should be considered in the differential diagnosis of other solid breast lesions. Only few cases have been reported in the literature. Diagnosis, optimal therapy and predicting the outcome are problematic issues due to the rarity of this disease which appears to have hematogenous rather than lymphatic spread and usually occurs in primary tumors ≥ 1.6 cm in size.

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“…In the reported cases of malignant AME of the breast, the histological subtypes of carcinoma are biphasic epithelial and myoepithelial carcinoma, 3,4,10,12–17,20,21,24,26 myoepithelial carcinoma, 2,7,18,22,23,25 adenosquamous carcinoma, 5 acantholytic squamous cell carcinoma, 8 invasive ductal carcinoma, 10,11,18 adenoid cystic carcinoma, 9 undifferentiated carcinoma 6 and metaplastic carcinoma 26 . To the best of our knowledge, no case of malignant AME combined with invasive lobular carcinoma (ILC) simultaneously in one breast tumor has been described.…”

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confidence: 99%

“…According to the most recent World Health Organization classification, the malignant component of malignant AME of the breast includes epithelial carcinoma, myoepithelial carcinoma, biphasic epithelial and myoepithelial carcinoma, sarcoma and carcinosarcoma. 27 In the reported cases of malignant AME of the breast, the histological subtypes of carcinoma are biphasic epithelial and myoepithelial carcinoma, 3,4,10,[12][13][14][15][16][17]20,21,24,26 myoepithelial carcinoma, 2,7,18,22,23,25 adenosquamous carcinoma, 5 acantholytic squamous cell carcinoma, 8 invasive ductal carcinoma, 10,11,18 adenoid cystic carcinoma, 9 undifferentiated carcinoma 6 and metaplastic carcinoma. 26 To the best of our knowledge, no case of malignant AME combined with invasive lobular carcinoma (ILC) simultaneously in one breast tumor has been described.…”

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confidence: 99%

Malignant adenomyoepithelioma of the breast combined with invasive lobular carcinoma

Honda

Iyama

2009

Pathology International

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Presented herein is the first case of malignant adenomyoepithelioma (malignant AME) of the breast combined with invasive lobular carcinoma (ILC) in a 53-year-old woman. Histologically, the tumor was composed of nodular proliferation of biphasic epithelial and myoepithelial carcinoma, partially surrounded by ILC. Interestingly, ILC metastasized to the axillary lymph nodes, while biphasic epithelial and myoepithelial carcinoma hematogenously metastasized to the lung and the kidney. On immunohistochemistry the biphasic carcinoma consisted of cytokeratin (CK) 8/18-positive/CK5/6-positive/smooth muscle actin (SMA)-negative inner carcinoma cells and CK8/18-positive/CK5/6-positive/SMA-positive outer carcinoma cells. The monophasic ILC cells had a CK8/18-positive/CK5/6-negative/SMA-negative staining pattern. Although it is unclear whether both ILC and biphasic epithelial and myoepithelial carcinoma originated from AME or whether ILC occurred independently of malignant AME, this is an exceptionally rare case, which might give rise to a special consideration of the histogenesis of breast cancer.

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Malignant adenomyoepithelioma of the breast with matrix production may be compatible with one variant form of matrix-producing carcinoma: A case report

Cited by 17 publications

References 17 publications

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Breast adenomyoepithelioma: a case report with malignant proliferation of epithelial and myoepithelial elements

Malignant adenomyoepithelioma of the breast combined with invasive lobular carcinoma

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