Malignant Ameloblastic Fibro-odontoma in a Dog

Ueki, Hidetaro; Sumi, Akiko; Takaishi, Hiromasa; Ito, Hiroshi; Oyamada, Toshifumi; Yoshikawa, Hiroki

doi:10.1354/vp.41-2-183

Cited by 23 publications

(19 citation statements)

References 3 publications

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“…These mixed masses are on a continuum with ameloblastic fibroma being the least inductive, lacking mineralization, and compound odontoma being the most inductive and consisting primarily of tooth‐like structures (denticles). While mixed inductive odontogenic neoplasms are considered benign and slow growing, metastasis have been reported . Further study is required to determine if CT is helpful in differentiating these different neoplastic and nonneoplastic mass types in dogs.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomographic Characteristics of Odontogenic Neoplasms in Dogs

Amory

Reetz

Sánchez

et al. 2013

Vet Radiology Ultrasound

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Odontogenic neoplasms are locally invasive oral tumors in dogs. The purpose of this retrospective study was to describe CT characteristics for varying histopathologic types of canine odontogenic neoplasms. A boardcertified veterinary radiologist who was unaware of histologic findings reviewed and scored imaging studies. A total of 29 dogs were included in the study. Twenty-three of these dogs had concurrent dental radiographs. The most common CT characteristics for all tumor types were a direct association with or in the region of multiple teeth in 96.4% (27/28), contrast enhancement in 96.3% (26/27), alveolar bone lysis in 93.1% (27/29), and mass-associated tooth displacement in 85.2% (23/27). Mass-associated cyst-like structures were identified in 53.6% (15/28) and were only present in tumors containing odontogenic epithelium. Canine acanthomatous ameloblastomas (n = 15) appeared as extra-osseous (10/15) or intra-osseous (5/15) masses. Intra-osseous canine acanthomatous ameloblastomas were more likely to have mass-associated cyst-like structures and were subjectively more aggressive when compared with extra-osseous canine acanthomatous ameloblastomas. Amyloid-producing odontogenic tumors (n = 3) had subjectively uniform CT imaging characteristics and consisted of round soft tissue and mineral attenuating masses with multiple associated cyst-like structures. Fibromatous epulides of periodontal ligament origin (n = 4) were contrast enhancing extra-osseous masses that were rarely referred for CT examinations and 25% (1/4) were not visible with CT. Other odontogenic tumors were less represented or had more variable CT imaging characteristics. Mass-associated tooth destruction was appreciated more often with dental radiographs and extra-oral tumor extension was identified more often with CT. C 2013 American College of Veterinary Radiology.

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Section: Discussionmentioning

confidence: 99%

Computed Tomographic Characteristics of Odontogenic Neoplasms in Dogs

Amory

Reetz

Sánchez

et al. 2013

Vet Radiology Ultrasound

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“…However, metastases to the lymph nodes, lungs, liver, and orbital cavity have been reported in a dog, and infiltration of adjacent soft tissues has been reported in a cow. 5,6,9 Radiographically, osteolysis is evident in ameloblastic fibromas, and foci of mineralization within the tumor have been reported. 3 Both odontomas and AFOs contain tooth substance and may be associated with a retained tooth, as seen in the current case.…”

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confidence: 99%

Ameloblastic Fibro-Odontoma Associated with a Retained Molar in an Oldenburg Mare

Knowles

Blás-Machado²,

Butler³

et al. 2010

J VET Diagn Invest

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Abstract. An 11-year-old Oldenburg mare presented with a 3-month history of weight loss and swelling of the posterior right mandible. Physical examination and radiographs showed a soft-tissue mass in the right mandible with foci of mineralization, periosteal proliferation, and a retained molar. The tumor increased in size over several weeks, and the mare was euthanized. On necropsy, a 24 cm 3 15 cm 3 15 cm firm, white mass had obliterated the posterior right mandible. The mass was multinodular with discrete clusters of blood-filled cystic spaces. Histologically, the mass was composed of neoplastic odontogenic epithelium and pulpal mesenchyme with an accumulation of eosinophilic material resembling dentin or enamel. Microscopic and immunohistochemical staining features of the neoplasm were most consistent with an ameloblastic fibroodontoma.

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“…A malignant odontogenic tumor that metastasized to multiple distal organs has been reported in a dog (20). Morphologic criteria for malignancy were pleomorphism, layering of secretory epithelium, invasion of surrounding tissue, high mitotic activity, anaplasia, and metastases (21).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Peripheral Ameloblastic Odontoma in a Male Sprague-Dawley Rat

Li¹,

Bae

Kim³

et al. 2017

ToxicolRes

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Peripheral ameloblastic odontoma is a rare variant of odontogenic tumor occurring in the extraosseous region. The present report describes a spontaneous tumor in male Sprague-Dawley (SD) rats. The clinically confirmed nodule in the right mandibular region was first observed when the rat was 42 weeks and remained until the terminal sacrifice date when the animal was 48 weeks of age. At necropsy, a well demarcated nodule, approximately 2.5 × 2.0 × 2.0 cm, protruded from the ventral area of the right mandible. The nodule was not attached to mandibular bone and was not continuous with the normal teeth. Histopathologically, the tumor was characterized by the simultaneous occurrence of an ameloblastomatous component and composite odontoma-like elements within the same tumor. The epithelial portion formed islands or cords resembling the follicle or plexiform pattern typical of ameloblastoma and was surrounded by mesenchymal tissue. Formation of eosinophilic and basophilic hard tissue matrix (dentin and enamel) resembling odontoma was observed in the center of the tumor. Mitotic figures were rare, and areas of cystic degeneration were present. Immunohistochemically, the epithelial component was positive for cytokeratin AE1/AE3 (CK AE1/AE3), and the mesenchymal component and odontoblast-like cells were positive for vimentin, in the same manner as in normal teeth. On the basis of these findings, the tumor was diagnosed as a peripheral ameloblastic odontoma in an extraosseous mandibular region in a SD rat. In the present study, we report the uncommon spontaneous peripheral ameloblastic odontoma in the SD rat. We also discuss here the morphological characteristics, origin, histochemical, and immunohistochemical features for the diagnosis of this tumor.

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Malignant Ameloblastic Fibro-odontoma in a Dog

Cited by 23 publications

References 3 publications

Computed Tomographic Characteristics of Odontogenic Neoplasms in Dogs

Computed Tomographic Characteristics of Odontogenic Neoplasms in Dogs

Ameloblastic Fibro-Odontoma Associated with a Retained Molar in an Oldenburg Mare

Spontaneous Peripheral Ameloblastic Odontoma in a Male Sprague-Dawley Rat

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