Malignant ameloblastoma or ameloblastic carcinoma

Slootweg, Pieter J.; Müller, Hellmuth

doi:10.1016/0030-4220(84)90207-x

Cited by 252 publications

(162 citation statements)

References 27 publications

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“…Although ameloblastic carcinoma was recognized very early by others [3][4][5] , the World Health Organization (who) classifications of 1971 6 and 1992 7 did not include the term in the section on odontogenic Current OnCOlOgy-VOlume 17, number 5 seen in the submandibular region 4-5 cm from the midline on the left side of the chin. The swelling was non-tender, variable in consistency, nonfluctuant, non-compressible, and fixed to underlying structures.…”

Section: Introductionmentioning

confidence: 99%

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Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature

et al. 2010

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carcinomas. Only in the updated who classification of 2005 was ameloblastic carcinoma listed as one of the odontogenic malignancies 8 .Ameloblastic carcinoma is defined as a rare malignant epithelial tumour that retains the histologic features of ameloblastic differentiation and yet also exhibits cytologic features of malignancy 1 . This malignant epithelial proliferation can be either carcinoma ex ameloblastoma or de novo ameloblastic carcinoma 1,7 .Here, we describe a case of spindle-cell ameloblastic carcinoma in a 60-year-old woman, with details of clinical, radiographic, and unusual histologic features suggesting that the tumour probably arose in a pre-existing unicystic ameloblastoma. To our knowledge, only 6 cases of ameloblastic carcinoma with spindle-cell histology have been published 4,9-11 , and of those, only 2 were diagnosed as spindle-cell ameloblastic carcinoma 12,13 . This third published case appears to be the first spindlecell ameloblastic carcinoma arising in a pre-existing unicystic ameloblastoma. CASE DESCRIPTIONIn March 2009, a 60-year-old woman presented in our department with a 19-year history of left mandibular swelling. She had first noticed a small swelling on the left side of the mandible for which she received surgical treatment in a government hospital in 1990, but no histology was done at that time. After 2 months, the swelling reoccurred, and the patient was again treated surgically, but she got no relief. The swelling gradually increased, reaching a size that had been causing the patient difficulty in eating and swallowing for 2-3 months before her presentation to us.Extraoral examination revealed a large irregular swelling in relation to the body of mandible on left side, extending to involve the ramus of mandible on the same side and across the midline to involve the parasymphyseal and right-side body of the mandible (Figure 1). The approximate size of the swelling was 15×9 cm. The overlying skin was smooth and normal in color, with a shiny surface. A sinus opening was ABSTRACT Spindle-cell differentiation in ameloblastic carcinoma is a rare event. Although reported by many authors, it was first described as a separate entity in 1999 by Slater under the heading "low-grade spindlecell ameloblastic carcinoma." Here, we report a case of low-grade spindle-cell ameloblastic carcinoma arising in pre-existing unicystic ameloblastoma.The patient, a 60-year-old Indian woman, had a large irregular swelling in the left mandibular region. Histologically, the lesion was composed of a large cystic cavity with an ameloblastomatous lining and areas showing spindle-cell proliferation. The spindle cells showed hyperchromatism, nuclear pleomorphism, and scattered mitotic figures. To our knowledge, 6 cases of spindle-cell ameloblastic carcinoma have been published to date, and this case appears to be the first reporting malignant transformation with spindle-cell differentiation in unicystic ameloblastoma.

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Section: Introductionmentioning

confidence: 99%

“…To our knowledge, only 6 cases of ameloblastic carcinoma with spindle-cell histology have been published 4,[9][10][11] , and of those, only 2 were diagnosed as spindle-cell ameloblastic carcinoma 12,13 . This third published case appears to be the first spindlecell ameloblastic carcinoma arising in a pre-existing unicystic ameloblastoma.…”

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confidence: 99%

Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature

et al. 2010

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“…Slootweg and Muller [1] subclassifed odontogenic carcinomas into three categories as they felt that these tumours exhibit considerable differences in biological behaviour and histomorphology. The sub-classification is as follows: Type 1.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the mandible: A case report and review of the literature

Abir

Abouchadi

Tourabi

et al. 2017

Med Buccale Chir Buccale

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-Aim:The purpose of this paper was to report an additional case of ameloblastic carcinoma of the left hemi-mandible and to review and analyze clinical, radiological and histopathologic features, treatment modalities and prognosis. Presentation of case: A 70 year old malepatient presented to Maxillofacial Department for a painful swelling of the left cheek. An ameloblastic carcinoma of the left hemi-mandible was diagnosed. He underwent radical surgical intervention comprising hemimandibulectomy, supraomohyoid neck dissection, and fibula free-flap reconstruction. Postoperative radiotherapy was employed. Discussion: Ameloblastic carcinoma of the mandible is a rare aggressive tumor with a poor prognosis. It can be seen in different ages. The most common symptom is a rapidly progressing painful swelling. It is defined as a malignant epithelial odontogenic tumor that retains the features of ameloblastic differentiation with cytologic features of malignancy. Non therapeutic consensus is established. However, wide surgical excision with radiotherapy is the most common treatment. Conclusion: Diagnosis of ameloblastic carcinoma at early stage and close periodic screening for metastasis are necessary to improve patient prognosis.

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“…In 1971, the term 'primary intraosseous carcinoma' (PIOC) was introduced (5). Elzay (6) reviewed the relevant literature associated with PIOC of the jaw and suggested an alteration to the World Health Organization (WHO) classification to include 'ameloblastic carcinoma', which was later modified to account for potential etiological factors (7). Intraosseous mucoepidermoid carcinoma was also later included as an additional form of PIOC (8).…”

Section: Introductionmentioning

confidence: 99%

Primary intraosseous squamous cell carcinoma of the mandible arising from an infected odontogenic cyst: A case report and review of the literature

Grisar

Schol²,

Hauben

et al. 2016

Oncology Letters

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Abstract. Primary intraosseous squamous cell carcinoma (PIOSCC) derived from a odontogenic cyst is a rare form of odontogenic carcinoma. The incidence of carcinomas arising from odontogenic cysts is particularly uncommon and is reported to occur in 1-2 individuals for every 1,000 cases. The present case describes a 25-year-old man who was initially diagnosed with a chronically infected odontogenic cyst of the mandible. Biopsy and subsequent histology revealed the presence of squamous cell carcinoma. Therefore, neck dissection and hemimandibulectomy were performed. Ultimately, the situation in the mouth healed, though with a severe amount of scarring. Although the development of PIOSCC from an odontogenic cyst is rare, it should be included in the differential diagnosis for jaw bone radiolucency.

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Malignant ameloblastoma or ameloblastic carcinoma

Cited by 252 publications

References 27 publications

Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature

Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature

Ameloblastic carcinoma of the mandible: A case report and review of the literature

Primary intraosseous squamous cell carcinoma of the mandible arising from an infected odontogenic cyst: A case report and review of the literature

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