Malignant Appendiceal GIST: Case Report and Review of the Literature

Elazary, Ram; Schlager, Avraham; Khalaileh, Abed; Appelbaum, Liat; Bala, Miklosh; Abu-Gazala, Mahmoud; Khatib, Areej; Neuman, Tzahi; Rivkind, Avraham I.; Almogy, Gidon

doi:10.1007/s12029-009-9113-8

Cited by 22 publications

(20 citation statements)

References 16 publications

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“…Three other tumors were found incidentally during surgery for other diseases or at autopsy [5, 7]. One other tumor was associated with acute appendicitis [7], and with a peri-appendiceal abscess for the last case [6]. For our case, the tumor was discovered when the patient presented with an acute peritonitis.…”

Section: Discussionmentioning

confidence: 82%

“…Seven of the eight previously reported appendiceal GISTs were spindled, mitotically inactive lesions corresponding to prognostic groups 1 (n = 6) and 2 (n = 1) according to Miettinen and Lasota [4] and were at very low risk (n = 6) and low risk (n = 1) according to the National Institutes of Health consensus criteria [9]. For one case, the size of the tumor, number of mitosis and locally invasive surgical findings clearly confirm the malignant nature of the lesion [6]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Appendiceal GIST: report of an exceptional case and review of the litterature

Bouassida¹,

Chtourou²,

Chalbi³

et al. 2013

Pan Afr Med J

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Gastro-intestinal stromal tumors (GISTs) of the appendix are a rare entity. To date, only eight cases has been described in the literature, most of which have been of the benign type. We report a new case of an appendiceal GIST in a 75-year-old man. The tumor was discovered when the patient presented with acute appendiceacal peritonitis. Preoperative diagnosis of appendiceal GIST was rarely done as tumors were usually associated with appendicitis-like symptoms.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Appendiceal GIST: report of an exceptional case and review of the litterature

Bouassida¹,

Chtourou²,

Chalbi³

et al. 2013

Pan Afr Med J

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“…GISTs of the vermiform appendix constitute only 0.1% of all GISTs (1), with only 16 cases reported in the English literature to date (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The characteristics of these 17 GIST cases (including the present case) are listed in Table I.…”

Section: Discussionmentioning

confidence: 87%

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

Kaneko

Kawai

Murono

et al. 2017

Molecular and Clinical Oncology

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Abstract.Gastrointestinal stromal tumors (GISTs) of the vermiform appendix are rare, measuring <3 cm in 82.4% of the reported cases. Neoadjuvant therapy with the receptor tyrosine kinase inhibitor imatinib mesylate has the potential to improve resectability and organ preservation rates in locally advanced or metastatic/recurrent GISTs. We herein report the case of a 67-year-old male patient with an unusually large GIST (22 cm in diameter) of uncertain origin in the right lower abdominal quadrant, with a solitary peritoneal metastasis. Due to the size of this GIST and presence of metastatic disease, neoadjuvant therapy with imatinib (400 mg/day orally) was administered. Follow-up imaging studies revealed marked shrinkage of the primary and metastatic tumors. Subsequently, laparoscopic exploration revealed that the main tumor originated from the tip of the vermiform appendix, and that the peritoneal metastasis was located in the ascending mesocolon. The patient underwent laparoscopic appendectomy and excision of the peritoneal metastasis, without tumor rupture. Therefore, in appropriately selected patients, neoadjuvant imatinib for borderline resectable or oligometastatic GISTs may be a reasonable choice.

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“…Even appendiceal gastrointestinal stromal tumor (GIST) has been uncommonly reported [18][19][20]. GIST may show a protean morphologic appearance and several growth patterns, also mimicking endocrine tumors, and positivity for cytokeratins has been well-described in rare cases [21], rendering the differentials very challenging.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Carcinoid of the Appendix: An Uncommon Variant of Lipid-Rich Neuroendocrine Tumor with a Broad Differential Diagnosis

et al. 2010

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The designation of clear cell/lipid-rich refers to an unusual variant of neuroendocrine tumor ("carcinoid") described in several organs, but only recently observed in the appendix. In this study, we report the morphologic, immunohistochemical, and ultrastructural features of an incidentally discovered appendiceal clear cell/lipid-rich carcinoid in a 32-year-old man without any evidence of von Hippel-Lindau disease. Differential diagnosis with mimicking neoplastic and non-tumor lesions, epidemiology, and clinical behavior of this exceedingly rare variant of carcinoid of the appendix are also discussed.

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Malignant Appendiceal GIST: Case Report and Review of the Literature

Cited by 22 publications

References 16 publications

Appendiceal GIST: report of an exceptional case and review of the litterature

Appendiceal GIST: report of an exceptional case and review of the litterature

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

Clear Cell Carcinoid of the Appendix: An Uncommon Variant of Lipid-Rich Neuroendocrine Tumor with a Broad Differential Diagnosis

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