Malignant Biliary Diseases

Koti, Rahul; Davidson, Brian R

doi:10.1002/9781444341294.ch13

Cited by 3 publications

(3 citation statements)

References 120 publications

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“…Interleukin 6 (IL-6), an inflammatory cytokine, appears to have a more definite role in the pathogenesis of BTC. The activation of EGFR, ERBB2 and HGF has also been reported in BTC (1,2). …”

Section: Introductionmentioning

confidence: 79%

“…Biliary tract cancers (BTCs) are a heterogeneous group of tumors arising from the epithelial cells of the intra- and extra-hepatic bile ducts and gallbladder (1,2). Histologically, the majority of BTCs are adenocarcinomas and have a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…Little is known about the molecular pathogenesis of BTC (1,2). Although alterations in a number of cancer-associated genes, including p53 and KRAS , have been identified as potential risk factors, the frequency of these alterations is low.…”

Section: Introductionmentioning

confidence: 99%

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Aberrant expression of the PHF14 gene in biliary tract cancer cells

et al. 2013

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DNA copy number aberrations in human biliary tract cancer (BTC) cell lines were investigated using a high-density oligonucleotide microarray. A novel homozygous deletion was detected at chromosomal region 7p21.3 in the OZ cell line. Further validation experiments using genomic PCR revealed a homozygous deletion of a single gene, plant homeodomain (PHD) finger protein 14 (PHF14). No PHF14 mRNA or protein expression was detected, thus demonstrating the absence of PHF14 expression in the OZ cell line. Although the PHD finger protein is considered to be involved in chromatin-mediated transcriptional regulation, little is known about the function of PHF14 in cancer. The present study observed that the knock down of PHF14 using small interfering RNA (siRNA) enhanced the growth of the BTC cells. These observations suggest that aberrant PHF14 expression may have a role in the tumorigenesis of BTC.

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Aberrant expression of the PHF14 gene in biliary tract cancer cells

et al. 2013

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Diagnóstico diferencial de la ictericia obstructiva

Tejedor

Martínez

2012

Medicine - Programa de Formación Médica Continuada Acreditado

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Use of fully covered self-expanding metal biliary stents for managing endoscopic biliary sphincterotomy related bleeding

et al. 2021

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Background and study aims Endoscopic biliary sphincterotomy (EBS) related-bleeding is a common adverse event related to endoscopic retrograde cholangiopancreatography (ERCP). Traditionally, endoscopic modalities such as epinephrine injection, cauterization, and balloon tamponade have been used for management. Recently, use of a fully covered self-expandable metal stent (FCSEMS) to manage EBS-related bleeding has gained popularity. However, data regarding its use are limited to small case series. Therefore, we aimed to evaluate the safety and efficacy of FCSEMS placement for the treatment of EBS-related bleeding. Patients and methods All patients referred to our center from October 2014 to November 2019 who had an FCSEMS placed for EBS-related bleeding were included. FCSEMS was placed either for primary control of bleeding or after failure of other traditional endoscopic hemostasis techniques at the discretion of the endoscopist. Data was collected regarding patient demographics, procedural characteristics, clinical and technical success rates of FCSEMS, as well as adverse events. Results A total of 97 patients underwent placement of FCSEMS for EBS-related bleeding, of which 76.3 % had immediate bleeding and 23.7 % had delayed bleeding. Mean age was 67.2 years and 47.4 % were males. Seven patients who had immediate EBS-related bleeding at index ERCP underwent other endoscopic therapies prior to placement of FCSEMS for rebleeding. The technical success rate for FCSEMS placement was 100 % and the rebleeding rate was 6.2 %. Four patients with FCSEMS placement developed pancreatitis and four had stent migration. Conclusions Our findings suggest that FCSEMS is a highly effective treatment modality for managing EBS-related bleeding and has an acceptable safety profile.

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Malignant Biliary Diseases

Cited by 3 publications

References 120 publications

Aberrant expression of the PHF14 gene in biliary tract cancer cells

Aberrant expression of the PHF14 gene in biliary tract cancer cells

Diagnóstico diferencial de la ictericia obstructiva

Use of fully covered self-expanding metal biliary stents for managing endoscopic biliary sphincterotomy related bleeding

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