Malignant blue nevus. Case report of a Negro woman

Kwittken, J; Negri, L

doi:10.1001/archderm.94.1.64

Cited by 19 publications

(8 citation statements)

References 4 publications

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“…In the small number of cases previously reported,23 678,149 151 17, 22 it closely resembles the cellular blue nevus (CBN) described by Allen and Spitz,8 and usually metastasizes to regional lymph nodes or more rarely to internal organs.8 Although it occurs primarily in the Caucasian blue nevus in a Negro woman has been reported. 17 Like the CBN, the MBN appears to follow a clinical course and present a histopathologic appearance which differs from that of a melanocarcinoma.2, 4 9 8 , 1.71143 16 T h e CBN and MEN described herein were unusually large. T h e great variation in morphological patterns warranted a detailed race,% 3, 6, 8, 1.1, 1% 22, 2 5 , 26 a case of a malignant report upon this neoplasm's histopathology.…”

Section: He Malignant Blue Nevus (Mbn) Is a Rarementioning

confidence: 75%

A cellular and malignant blue nevus: A light and electron microscopic study

Merkow

Burt

Hayeslip

et al. 1969

Cancer

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A rare malignant blue nevus resected from the back of a 34‐year‐old Caucasian woman is reported. Histopathologic examination showed the presence of a CBN as well as MBN. The CBN elements of this lesion showed the characteristic prominent neural type fascicles intertwined with melanocytes. The deeper regions of this skin neoplasm showed considerable variation in histopathologic patterns. Metastascs to the axillary lymph nodes and multiple subdermal soft tissue sites, invasion of the underlying skeletal muscle, and several recurrences in the chest wall indicate that this neoplasm is malignant, though of a lower order than a malignant melanoma. The ultrastructural characteristics of neoplastic cells indicate that this neoplasm is of Schwann cell origin.

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Section: He Malignant Blue Nevus (Mbn) Is a Rarementioning

confidence: 75%

A cellular and malignant blue nevus: A light and electron microscopic study

Merkow

Burt

Hayeslip

et al. 1969

Cancer

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“…Overall, there is a slight male preponderance described in the literature (56 lesions in males compared with 51 women)-in contrast to our findings (9 men to 15 women). The most common anatomic site for these lesions is the head and neck region in 52 cases, 4,5,7,11,13,[15][16][17][18][19][20][21]23,24,27,28,31,33,36,39,42,[46][47][48]51,53 followed by the trunk in 28 cases, 4,5,7,[11][12][13]16,18,25,32,34,35,38,43,45,50,52 the lower extremity in 11 cases, 4,7,13,14,26,30,33...…”

Section: Discussionmentioning

confidence: 99%

“…Regarding pathologic findings, the reported cases (in order of frequency) included malignant melanocytic proliferations mimicking a cellular blue nevus but lacking an identifiable benign component (in 38% of cases) 5,11,[13][14][15]18,20,25,28,30,33,36,47,49 or melanomas arising in association with a distinctive blue nevus component, including (a) cellular blue nevus (26%), 4,5,11,16,18,29,40,46,50,51,53 (b) common blue nevus (21%), 5,13,22,24,27,31,32,34,37,39,41,43,52 (c) both cellular and common blue nevus (13%), 12,16,21,23,35,38,44,45,48 (d) neurocristic hamartoma (1%) 42 and (e) nevus of Ota (1%). 17 In contrast, all of the cases in our series consisted of distinctly biphenotypic melanocytic proliferations (melanoma together with a benign blue nevus component).…”

Section: Discussionmentioning

confidence: 99%

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

et al. 2014

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Melanomas arising in association with blue nevi or mimicking cellular blue nevi comprise a relatively rare and heterogeneous group of melanomas. It remains controversial which prognostic indicators predictive of outcome in conventional cutaneous melanomas are applicable to this type of melanoma. Here, we describe the clinical and histopathologic features of 24 melanomas arising in association with blue nevi and correlate these with clinical outcome. The mean patient age was 49 years (range: 23-85) with a slight female predominance (15 females:9 males). The most common anatomic locations included the head and neck region (50%), the trunk (21%), and the buttock/sacrococcygeum (17%). Histologically, the tumors were typically situated in the mid to deep dermis with variable involvement of the subcutis, but uniformly lacked a prominent intraepithelial component. The mean tumor thickness (defined as either the standard Breslow thickness or, if not available due to the lack of orientation or lack of epidermis, the largest tumor dimension) was 20.9 mm (range: 0.6-130 mm). The mean mitotic figure count was 6.5/mm 2 (range: 1-30/mm 2 ). Perineural invasion was common (38%). Followup was available for 21 cases (median 2.1 years). The median overall survival, recurrence-free survival, time to local recurrence, and time to distant recurrence were 5.2, 0.7, 2.6, and 1.6 years, respectively. Logistic regression analyses demonstrated a significant association between tumor thickness and recurrence-free survival (hazard ratio ¼ 1.02 per mm; P ¼ 0.04) and reduced time to distant metastasis (hazard ratio ¼ 1.03 per mm; P ¼ 0.02) with a similar trend toward reduced time to local recurrence (hazard ratio ¼ 1.02 per mm; P ¼ 0.07). No other parameters (age, anatomic location, mitotic figures, lymphovascular or perineural invasion, or type of associated blue nevus) emerged as significant. In addition, we provide a comprehensive review of 109 cases of melanoma blue nevus type described in the English literature and summarize our findings in this context.

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“…The follow-up period varied tremendously in these cases from 12 to 228 months with an average of nearly 59 months. While most MBN metastasize within 1-2 years [1,8,11,13], there are 5 reports of delayed metastasis from 5 to 19 years after initial surgery [11,[34][35][36], suggesting that malignancy cannot be ruled out in a small percent of cases without extensive follow-up. In our case, tumor was transected at the deep and lateral surgical margins, potentially predisposing to regrowth [23,37].…”

Section: Discussionmentioning

confidence: 99%