Malignant brain stem hyperthermia caused by brain stem hemorrhage.

Kitanaka, Chifumi; Inoh, Y; Toyoda, Tomohiko; Sasaki, Takenori; Eguchi, Takahiko

doi:10.1161/01.str.25.2.518

Cited by 22 publications

(11 citation statements)

References 5 publications

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“…Direct damage to the thermoregulatory centers in the hypothalamus and brainstem has been anecdotally reported as the cause of severe hyperthermia. 25,26 This is probably not a major factor in our study in patients with supratentorial hemorrhage. In our study, fever was independent of the hematoma location; in particular, thalamic hemorrhage was not associated with the presence of fever, but fever was strongly associated with intraventricular hemorrhage.…”

Section: Discussionmentioning

confidence: 75%

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Status epilepticus in stroke

Rumbach¹,

Sablot²,

Berger³

et al. 2000

Neurology

147

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Section: Discussionmentioning

confidence: 75%

“…[16][17][18][19][20][21][22][23][24] By contrast, in articles dealing specifically with SE, cerebrovascular disease is cited as being one of the most common causes of SE (20% of cases). 1,4,25,26 The heterogeneity of the reported percentages is probably related to the differences in study designs.…”

Section: Discussionmentioning

confidence: 99%

Status epilepticus in stroke

Rumbach¹,

Sablot²,

Berger³

et al. 2000

Neurology

147

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“…There are some studies on this subject but no convincing conclusions [1,2,3,4,5,6,7]. The main difficulty is differentiating hyperthermia of central origin from fever due to infection in patients with brain lesions and high fever.…”

Section: Introductionmentioning

confidence: 99%

Central Hyperthermia in Acute Stroke

Sung

Lee

Chu³

2009

Eur Neurol

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Background: Central hyperthermia is an unresolved riddle; this study tries to define its characteristics. Methods: Seventy-four previously healthy patients who developed hyperthermia (≥39°C) within 24 h after stroke onset were enrolled. The lesion sites, nature of stroke, and clinical features were studied. Results: Brainstem hemorrhage was the most common cause of hyperthermia (64%), followed by putamino-thalamus hemorrhage (24%), cerebellum hemorrhage (4%), large cortical infarct (4%), basilar artery occlusion (3%), and intraventricular hemorrhage (1%). Whatever the site of the lesion, all patients had brainstem involvement either by direct destruction or indirect compression. Three fourths of the patients reached 39°C within 12 h of stroke, and 82% arrived at the maximum within 24 h. A peculiar finding of central hyperthermia was the marked fluctuation in body temperature within a short period, which was more severe initially then decreased gradually. Leukocytosis was seen in 60%, but shift to the left was rare (1%). The prognosis was grave, nearly 70% of the patients expired within 1 month, especially those with a temperature of >41°C or those who reached 39°C within 6 h after onset of stroke, or those who had severe fluctuations in temperature. Conclusions: Central hyperthermia is characterized by rapid onset of high fever, marked temperature fluctuation and high mortality. It is likely associated with brainstem (mainly pons) damage by direct destruction or indirect compression.

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“…This model can be applied toward testing treatment strategies and pathophysiological mechanisms. Also, the observed sustained temperature elevation was consistent with the hyperthermia described in several human clinical case reports of brainstem hemorrhage [5], and needs to be explored further. Finally, future studies are needed to elucidate the molecular mechanisms involved with the corresponding neurological deficits, brain edema, hemorrhagic volume, and temperature elevations.…”

Section: Discussionsupporting

confidence: 83%

A rat model of pontine hemorrhage

Lekic

Tang

Zhang

Cerebral Hemorrhage

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SummaryApproximately 15% of all strokes are due to intracerebral hemorrhage, and of these, 5 to 9% will occur in the pons, with mortality approximately 60% of the time. However, there is not an adequate animal model to fully address this important clinical problem.To this end, pontine hemorrhage was induced in rats using stereotaxic injection of 0.15 units of collagenase. At 24, 48, and 72 h (n ¼ 4 per group), the hemorrhagic volume, brain water content, body temperature, and neurological function (corner turn, inclined plane, and neurological deficit score) were assessed. All tested parameters were significantly increased, compared to sham, without any differences between time points. Furthermore, the extent of brainstem edema was highly correlated with neurological score, inclined plane, and body temperature. This new pontine hemorrhage rat model demonstrated brain edema and neurological deficits, and can be used to test treatment strategies for pontine hemorrhage.

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Malignant brain stem hyperthermia caused by brain stem hemorrhage.

Cited by 22 publications

References 5 publications

Status epilepticus in stroke

Status epilepticus in stroke

Central Hyperthermia in Acute Stroke

A rat model of pontine hemorrhage

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