Malignant Brenner tumour of the ovary manifesting as distal intestinal obstruction and perforation

Abstract

A rare case of malignant Brenner tumour of ovary manifesting with intestinal perforation due to colonic infiltration is elaborated in the present report. Brenner’s tumour accounts for 1%–2% of all ovarian neoplasms and malignant Brenner tumour is even rarer and only about 5% of Brenner tumours are malignant. A 62-year-old woman came to surgical emergency with 1-month history of abdominal pain, vomiting and constipation with a palpable mass in right iliac fossa. Abdominal radiograph was suggestive of colonic obstruction. Contrast-enhanced CT of the abdomen revealed cystic right ovarian mass of 10.2×8.8 cm2 with pneumoperitoneum. Exploratory laparotomy was done, which revealed mass arising from right ovary involving terminal ileum, cecum and ascending colon. Possibility of ovarian malignancy was kept. Patient underwent debulking surgery along with ileostomy and descending colon mucous fistula was created. Histology was compatible with malignant Brenner tumour of the ovary.

Malignant Brenner Tumor of the Ovary: A Systematic Review of the Literature

“…The publication years ranged from 1956 to 2023. The age in 108/115 (93.9%) cases [ 2 , 8 , 9 , 10 , 11 , 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ] was reported. Specifically, the mean age at presentation was 59 ± 13 years, ranging from 22 to 87 years.…”

“…Specifically, the mean age at presentation was 59 ± 13 years, ranging from 22 to 87 years. Presenting symptoms were reported in 113/115 (98.3%) patients [ 2 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. The most common presenting symptom was abdominal pain, which was present in 42/113 patients (37.1%) [ 2 , 13 , 19 , 22 , 26 , 27 , …”

“…The most common presenting symptom was abdominal pain, which was present in 42/113 patients (37.1%) [ 2 , 13 , 19 , 22 , 26 , 27 , 30 , 36 , 37 , 38 , 39 , 40 , 41 , 45 , 47 , 48 , 49 , 51 ], followed by adnexal mass (15/113, 13.3%) [ 13 , 24 , 51 ], abdominal/pelvic mass (15/113, 13.3%) [ 24 , 31 , 35 , 36 , 40 , 42 , 43 , 44 , 48 , 53 ], abdominal distention (16/113, 14.1%) [ 13 , 14 , 34 , 36 , 40 , 43 , 48 , 52 ], vaginal bleeding (15/113, 13.3%) [ 10 , 13 , 21 , 24 , 25 , 27 , 38 , 40 , 43 , 48 ], weight loss (8/113, 7.1%) [ 20 , 25 , 26 , …”

A Case of Malignant Brenner Tumor of the Ovary Incidentally Found in a Patient with Deep Vein Thrombosis

“…There are other types of ovarian tumors, such as serous, mucinous, endometrioid, and clear cell carcinomas, as well as benign Brenner tumors, teratomas, and metastases from urinary tract tumors, which should be considered in the differential diagnosis of MBT. Metastasis from other organs, such as the urinary bladder or colorectum, should also be ruled out [4].…”

“…Surgical excision and pathological evaluation are necessary to diagnose MBT because it lacks specific imaging features. Treatment consists of surgical resection, and the prognosis of MBT is generally favorable [1][2][3][4].…”