Malignant Brenner Tumour of the Ovary: A Rare Entity

Abstract

Malignant Brenner tumors (MBTs) of the ovary are very rare, and their definition, biology and treatment modality have not been established. Most Brenner tumors are benign, with only 1% being malignant. In this study we present a case of 30 years old women with a rare malignant Brenner tumour. She presented at a peripheral referral hospital with a complaint of abdominal pain and mass. Ultrasonography revealed left sided ovarian tumours. She is referred for evaluation of a complex pelvic mass and elevated serum CA-125 level. She underwent left salpingo-oophorectomy and the specimen was sent for histopathological study. Histopathology revealed malignant Brenner tumour. Immunohistochemistry tumour cells are positive for pancytokeratin and negative for CK7/CK8/WT1/Pax8/CA125/calretinin/inhibin.