Malignant Carotid Body Tumor with Systemic Metastases

Nishijima, Hironobu; Asakage, Takahiro; Sugasawa, Masashi

doi:10.1177/000348941112000606

Cited by 23 publications

(35 citation statements)

References 14 publications

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“…This frequency was compatible with previous reports (4)(5)(6)(7)21). It is well known that, as histopathological examination cannot distinguish a malignant tumor by morphological features in microscopic findings, malignancy or not is diagnosed by metastatic activity, namely clinical findings.…”

Section: Shamblin Classification ------------------------------------supporting

confidence: 92%

Multi-institutional survey of carotid body tumors in Japan

et al. 2018

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Abstract. There has been no attempt to clarify the status of patients with carotid body tumor (CBT) in Japan. This multi-institutional survey analyzed patients with CBT throughout Japan by gathering information on these patients from institutions that performed head and neck surgeries. Information from a total of 150 patients from 25 institutions from the past 20 years was employed in the present survey. There were 87 females and 63 males, and their mean age was 48.0 years old. The most common chief complaint was a neck mass and the mean suffering period was 46.1 months. Eighteen patients had a family history of paragangliomas and fifteen patients had bilateral CBTs. Among the 94 patients who underwent surgery to remove a CBT, 23 patients had tumors classified as Shamblin type I, 59 had type II and 12 had type III. The most frequent feeding artery of these CBTs was the ascending pharyngeal artery. Preoperative embolization of these arteries was effective in reducing blood loss; however, the operation time in Shamblin type I and II tumors was not improved. Thus these results revealed the status of patients with CBT and their treatment throughout Japan.

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Section: Shamblin Classification ------------------------------------supporting

confidence: 92%

Multi-institutional survey of carotid body tumors in Japan

et al. 2018

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“…Moreover, the report states that not all cases with distant metastasis necessarily have a bad prognosis. 14,15 We focused our study to primary head and neck paragangliomas, however, excluded from our study series, there were 3 patients with ''secondary'' head and neck paragangliomas (2 metastatic disease and 1 case of possible metastatic vs second primary in a patient with prior pheochromocytoma). SDHB germline mutation was detected in one of the above cases with extensive metastatic paragangliomas including a 5.1 cm frontal mass and multiple positive lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Is Regional Lymph Node Metastasis of Head and Neck Paraganglioma a Sign of Aggressive Clinical Behavior: A Clinical/Pathologic Review

et al. 2019

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Background: Head and neck paraganglioma is a rare neoplasm of the paraganglia. It accounts for <1% of all head and neck tumors. It usually has benign clinical course; however, malignant paraganglioma can only be diagnosed by showing metastatic disease. We undertook a retrospective study to assess the clinical significance of regional lymph nodes metastases in head and neck paragangliomas. Design: From 1993 to 2016, primary head and neck paragangliomas are identified. The patient clinical and histopathologic materials were reviewed. Results: Sixty-five specimens from 62 patients (3 patients with more than 1 specimens) with head and neck paragangliomas were recorded (49 female and 13 males) with mean age of 54 (24-78 years). The locations of the tumors were as follows: carotid body: 30, glomus tympanicum: 11, glomus jugulare: 14, parapharyngeal space: 3, and 1 case each of larynx, skull base, paraglottic area, infratemporal fossa, mastoid, cerebellopontine (CP) angle, and pyriform sinus. On histopathology, we found 5 cases of sclerosing variant. Thirty-two (52%) of the 62 patients had regional lymph node biopsy. Four (12%) of the 32 show metastatic paraganglioma (3 females and 1 male with mean age = 35). Two of the 5 cases of sclerosing variant had positive lymph nodes. No evidence of local recurrence or distant metastasis in the patients with positive lymph nodes with a 6 to 11 years follow-up. One of the 28 patients with negative lymph nodes developed metastatic disease to lumbar spine in 5 years. Conclusion: Metastatic paraganglioma to regional lymph nodes may have indolent clinical behavior, with disease-free survival of up to 11 years. The incidence of metastatic disease in lymph nodes was 4 (12%) of 32. Forty percent (2/5) of the cases with sclerosing variant of paraganglioma had lymph node metastases indicating that this tumor may have a more aggressive histological behavior.

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“…CBTs are often diagnosed using the location, clinical symptoms and imaging findings of the tumor (13). The majority of CBTs are benign; however, certain lesions may demonstrate malignant inclinations and behavior.…”

Section: Discussionmentioning

confidence: 99%

“…However, other studies considered that pathological examinations do not allow the differentiation between benign and malignant tumors. Only the presence of regional lymph nodes or distant metastasis may indicate malignancy (3,13,(15)(16)(17). Therefore, malignant CBTs are usually diagnosed using the development of local recurrence, regional lymph node metastasis or the presence of distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Imaging findings of malignant bilateral carotid body tumors: A case report and review of the literature

Chen

Zhou

et al. 2016

Oncology Letters

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Abstract. Carotid body tumors (CBTs) are a rare type of extra-adrenal paraganglioma, which originate from the carotid body. A 29-year-old woman was admitted to the Department of Head and Neck Surgery, Beijing Tongren Hospital (Capital Medical University, Beijing, China) with hoarseness of the throat, which had progressively worsened over seven months. The patient had a family history of CBTs. Computed tomography and ultrasound imaging revealed multiple well-enhanced masses located at the bilateral carotid bifurcation and in the left parapharyngeal space. Surgery and pathological examination confirmed that the patient had developed regional lymph node metastasis. Significantly enhanced multiple pulmonary and hepatic lesions indicated that the patient had also developed distal metastasis. A genetic analysis performed on the family members of the patient revealed that the family carried a mutated succinate dehydrogenase D gene. In the present study, a systemic review of the literature indicated that extra vigilance is required in familial forms of CBT, in order to increase the standard of treatment for CBT patients.

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Malignant Carotid Body Tumor with Systemic Metastases

Cited by 23 publications

References 14 publications

Multi-institutional survey of carotid body tumors in Japan

Multi-institutional survey of carotid body tumors in Japan

Is Regional Lymph Node Metastasis of Head and Neck Paraganglioma a Sign of Aggressive Clinical Behavior: A Clinical/Pathologic Review

Imaging findings of malignant bilateral carotid body tumors: A case report and review of the literature

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