Malignant central nervous system tumors among adolescents and young adults (15‐39 years old) in 14 Southern‐Eastern European registries and the US Surveillance, Epidemiology, and End Results program: Mortality and survival patterns

Georgakis, Marios K.; Papathoma, Paraskevi; Ryzhov, Anton; Živković-Perišić, Snežana; Taraszkiewicz, Łukasz; Šekerija, Mario; Žagar, Tina; Antunes, Luís; Zborovskaya, A.; Bastos, Joana; Florea, Margareta; Coza, Daniela; Demetriou, Anna; Agius, Domenic; Strahinja, Rajko M.; Themistocleous, Marios; Tolia, Maria; Tzanis, Spyridon; Alexiou, George Α.; Papanikolaou, Panagiotis G.; Nomikos, P.; Καντζάνου, Μαρία; Dessypris, Nick; Pourtsidis, Apostolos; Petridou, Eleni

doi:10.1002/cncr.30884

Cited by 19 publications

(31 citation statements)

References 42 publications

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“…The proportion of microscopically verified tumours referred specifically to brain tumours in four studies, (7,13,18,19) while in five the parameter was for all tumours combined. (15,(20)(21)(22)(23) In the two international comparisons, the proportion of microscopically verified tumours varied between 57% and 96% (South-Eastern European (SEE) consortium, plus US), and between 61% and 95% in the EUROCARE-5 study, covering adolescents and young adults diagnosed during 1999-2007 in 27…”

Section: Resultsmentioning

confidence: 97%

“…Only one study included any data from middle-income countries (Table 1). (13) Young adults were defined as individuals up to the age of 24 years in six studies, up to age 39 in six studies, and up to age 44 in three studies. Three studies adopted alternative age definitions of the upper boundary (29, 40, or 49 years).…”

Section: Resultsmentioning

confidence: 99%

“…In the same countries, survival was lower (75%) when individuals up to age 39 (49 years in one study) were also included. (13,27,30) In the SEE consortium, five-year survival for patients diagnosed in 2005 was much lower (59%, 15-39 year-olds) (Figure 4). 13Five-year survival from high-grade astrocytoma (WHO grade III and IV combined) was 18% in England, in 1997, (27) while it varied between 27% and 39% in Germany, United States and the SEE consortium, during 2002-2005 ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

“…13Five-year survival from high-grade astrocytoma (WHO grade III and IV combined) was 18% in England, in 1997, (27) while it varied between 27% and 39% in Germany, United States and the SEE consortium, during 2002-2005 ( Figure 4). (13,30) Five-year survival from diffuse astrocytoma was in the range 63-76% in Germany and the US, during 2002-2007. (13,19,30) In both the EUROCARE-5 consortium (27 European countries combined) and the SEE consortium (Southern and Eastern Europe), average five-year survival was around 55% in 2005 ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

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Global trends in survival from brain tumours in adolescents and young adults: a systematic review.

Girardi

Allemani

Coleman

2019

Preprint

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Background Brain tumours represent an important cause of cancer-related death in adolescents and young adults. Most are diagnosed in low-income and middle-income countries. We aimed to conduct the first systematic review of time trends and geographical variation in survival in this age group. Methods We included observational studies describing population-based survival from astrocytic tumours in patients aged 15-39 years. We queried six electronic databases from database inception to 30 September 2018. This review is registered with PROSPERO, number CRD42018111981. Results Among 5,245 retrieved records, 20 studies fulfilled the inclusion criteria. Only one study was partly conducted in middle-income countries. Five-year survival from astrocytoma (broad morphology group) varied between 48% and 71% (1973-2004), without clear trends or geographic differences. Adolescents with astrocytoma had better outcomes than young adults, but survival values were similar when non-malignant tumours were excluded. During 2002-2007, five-year survival for WHO grade I-II tumours was in the range 75-93% in England, Germany, and the US, but lower in South-Eastern Europe (59%). Five-year survival for anaplastic astrocytoma varied between 40% and 55% (2002-2007). Five-year survival from glioblastoma was in the range 15-23% (1991-2009). Conclusions Survival from astrocytic tumours remained somewhat steady over time, with little change between 1973 and 2009. Survival disparities were difficult to examine, because nearly all the studies were conducted in affluent countries. Studies often adopted the International Classification of Childhood Cancer, which, however, did not allow to accurately describe variation in survival. Larger studies are warranted, including under-represented populations and providing more recent survival estimates. Keywords Population-based survival, brain tumours, adolescents, young adults, time trends.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Global trends in survival from brain tumours in adolescents and young adults: a systematic review.

Girardi

Allemani

Coleman

2019

Preprint

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“…Few reports show a decreased mortality in brain and nervous system cancer. It is possible that this discordant data may be due to advances in the diagnosis and treatment which may not be readily available in some geographical areas [28].…”

Section: Mortality In Young Adult Menmentioning

confidence: 99%

Cancer incidence and mortality trends in Metropolitan Lima young adults, 1990–2012

Luna‐Abanto¹,

Ruiz²,

Laura-Martinez³

et al. 2020

ecancer

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Aims: The purpose of this research was to calculate and compare standardised incidence and mortality ratios in young adults, based on the data published by the population-based cancer registry of Metropolitan Lima. Method: A secondary analysis was carried out on the data published by the population-based cancer registry of Metropolitan Lima in its last five volumes. Calculating the standardised incidence ratio, in accordance with the World Health Organization's standard population, was done using the direct method, and the annual percentage change was calculated using the Joinpoint Regression Program. Results: From 1990 to 2012, 12,380 new cases of cancer in young adults between the ages of 20 and 49 were reported in Metropolitan Lima. The neoplasms with the highest standardised incidence ratio in the young adult male group were testicular cancer, brain and nervous system cancer, stomach cancer, non-Hodgkin's lymphoma and bowel cancer. The neoplasms with the highest standardised mortality ratio for this group were stomach cancer, brain and nervous system cancer, non-Hodgkin's lymphoma, tracheal cancer, bronchial and lung cancer and liver cancer. The neoplasms with the highest standardised incidence ratio in the young adult female group were breast cancer, cervical cancer, thyroid cancer, ovarian cancer and brain and nervous system cancer. The neoplasms with the highest standardised mortality ratio for this group were breast cancer, cervical cancer, stomach cancer, brain and nervous system cancer and non-Hodgkin's lymphoma. Conclusions: Young adults represent a highly unique group, characterised by little diagnostic suspicion, distribution and aggressiveness of the neoplasms that occur in them. Assessing and reporting incidence and mortality ratios in this age group can contribute to decision making.

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Ependymomas in Children and Adults

Lampros

Vlachos

Alexiou

2023

Advances in Experimental Medicine and Biology

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Malignant central nervous system tumors among adolescents and young adults (15‐39 years old) in 14 Southern‐Eastern European registries and the US Surveillance, Epidemiology, and End Results program: Mortality and survival patterns

Cited by 19 publications

References 42 publications

Global trends in survival from brain tumours in adolescents and young adults: a systematic review.

Global trends in survival from brain tumours in adolescents and young adults: a systematic review.

Cancer incidence and mortality trends in Metropolitan Lima young adults, 1990–2012

Ependymomas in Children and Adults

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