MALIGNANT CHEMODECTOMA (PARAGANGLIOMA) OF THE LARYNX A Case Report with Electron Microscopy and Biochemical Assay

Ohsawa, Motoko; Kurita, Yukio; Horie, Akio; Kurita, Kenichi

doi:10.1111/j.1440-1827.1983.tb02173.x

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…The clinical and pathological data for 127 of these [1, are listed in table 1. Although data for individual cases were not supplied in the recent report of 41 cases by Milroy et al [57], infor mation regarding 5 of their cases had appeared in earlier publica tions [4,7,13,28,47], Four cases [10, 11 ; 16, 17; 24, 25; 44, 45] had been published twice; at least eight of the tumors [4,5,7,12,[26][27][28]33] had been reported earlier as paragangliomas (table 2); and seven LAC (supplied by Dr. Alfio Ferlito and Dr. James Woodruff) appear in print for the first time in this article (tables 1,3). Additional data obtained by communication with the authors or culled from the literature has been provided for many of these cases.…”

Section: Methodsmentioning

confidence: 99%

Atypical Carcinoid Tumor of the Larynx

Woodruff

Senie

1991

ORL

102

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To better characterize the clinical and pathological features of the laryngeal atypical carcinoid (LAC), 127 of the published cases were analyzed. The LAC had a predilection for males (3 m:1 f), with a peak incidence in the 6th and 7th decades of life. Seventy-eight percent of patients with a relevant clinical history were smokers. Most tumors presented in the supraglottic larynx (96%) and the mean size of the measured primary lesions was 1.6 cm. The tumors were frequently argyrophil (97% of those so stained), rarely argentaffin (2 cases), and on immunohisto-chemistry were often reactive when stained for keratins (96%), chromogranin A (94%), and calcitonin (80%). Surgical resection was the principal modality of treatment. Of the 127 cases, metastasis to neck nodes were found in 43%, to skin or subcutaneous sites in 22%, and to distant sites in 44%. Of the 119 patients with follow-up, 49% died with tumor. The cumulative proportion surviving was 48% at 5 years and 30% at 10 years, and there were significantly worse survival rates among patients with tumors larger than 1 cm, and for patients developing tumor involvement of skin and subcutaneous tissues. Adjuvant radiation did not affect survival rates.

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Section: Methodsmentioning

confidence: 99%

Atypical Carcinoid Tumor of the Larynx

Woodruff

Senie

1991

ORL

102

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“…6 Ohsawa et al (1983) described a 2.8 cm malignant paraganglioma arising from the epiglottis submucosa in a 47-year-old man who presented with laryngeal discomfort. 25 Granulomatous diseases that may cause an epiglottis mass include tuberculosis, sarcoidosis, and Wegener's granulomatosis. When sarcoidosis involves the larynx, it most often involves the epiglottis and manifests with erythema, edema, punctate nodules, and mass lesions.…”

Section: Discussionmentioning

confidence: 99%

Epiglottic masses identified on CT imaging: A case report and review of the broad differential diagnosis

et al. 2015

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Epiglottic masses may be cystic, granulomatous, infectious, benign or malignant neoplastic, or manifestations of a systemic disease. When large in size, the airway may become obstructed, and when accompanied by suspicious features such as cartilaginous invasion, extension to the pre-epiglottic or para-glottic spaces, or lymphadenopathy, the radiologist must consider malignancy as a primary differential diagnosis. However, when only benign features are identified, the differential diagnosis is broad. We present a 65-year-old female with an incidental 1 cm exophytic, pedunculated, papillomatous lesion on the laryngeal surface of the epiglottis discovered upon endoscopic evaluation for dyspepsia and heartburn. Because of her risk factors for malignancy, CT scan was requested and revealed only benign features. Subsequent excisional biopsy revealed a benign squamous papilloma; however, multiple additional differential considerations were entertained preoperatively.

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An Autopsy Case of Malignant Rhabdoid Tumor Arising From Soft Parts in the Left Inguinal Region

Uchida¹,

Yokoyama²,

Nakayama³

et al. 1988

Acta Pathologica Japonica

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An autopsy case of malignant rhabdoid tumor arising from soft parts in the left inguinal region of a 31‐year‐old Japanese male is reported. The tumor grew rapidly and appeared as a large mass measuring 21.5 × 16.5 cm located in the subcutaneous tissues of the lower abdominal wall. Histologically the tumor was composed of small round cells resembling rhabdomyoblasts, which showed a diffuse or alveolar arrangement. The cytoplasm of the tumor cells was eosinophilic and frequently contained round inclusion bodies, each consisting of an aggregation of globular filaments by electron microscopy. Immunohistochemistry showed the tumor cells to be positive for vimentin and keratin in the cytoplasm, but negative for actin, myoglobin and myosin. At autopsy, extensive metastatic or invasive tumors were observed mainly in the retroperitoneum and pelvic organs. The patient showed hypercalcemia which disappeared for only short periods just after surgery. ACTA PATHOL JPN 38: 1087∼1096, 1988.

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MALIGNANT CHEMODECTOMA (PARAGANGLIOMA) OF THE LARYNX A Case Report with Electron Microscopy and Biochemical Assay

Cited by 6 publications

References 10 publications

Atypical Carcinoid Tumor of the Larynx

Atypical Carcinoid Tumor of the Larynx

Epiglottic masses identified on CT imaging: A case report and review of the broad differential diagnosis

An Autopsy Case of Malignant Rhabdoid Tumor Arising From Soft Parts in the Left Inguinal Region

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