Malignant cystic epithelial‐stromal tumor of the prostate

Abstract

A huge cystic tumor in the pelvis of a 62-year old man, cytologically by fine needle aspiration biopsy, was composed of malignant spindle cells and transitional as well as glandular epithelial cells. Histochemical, immunostaining, and ultrastructural studies of the aspirated specimens and on the radically resected tumor indicated that the neoplastic cells are of prostatic fibroleiomyomatous stromal and epithelial origin. The lesion did not extend to the urothelium of the urinary bladder. This tumor resembles the rare cystadenoleiomyofibroma of the prostate, yet the cytologic abnormalities suggest a malignant potential. Long-term follow-up and recognition of additional cases are necessary to define the biologic behavior of this neoplasm.

Malignant phyllodes tumor of the prostate

“…Analogous to neoplasms of the breast, a spectrum of epithelial-stromal lesions has been described in the prostate. [1][2][3][4][5][6][7] Like the homonymous lesions of the breast, phyllodes tumors of the prostate vary in their histological appear- ance and clinical behavior. Phyllodes tumors of the prostate display an admixture of variably cellular stroma and benign glandular elements.…”

“…Phyllodes tumor of the prostate, first described by Cox and Dawson 1 in 1960, is an uncommon tumor. This tumor has been termed various other names, including cystic adenoma of the prostate, 2 cystadenoleiomyofibroma, 3 cystic epithelial stromal tumor, 4 phyllodes type of atypical hyperplasia, 5 and cystosarcoma phyllodes. 6 Although most of malignant phyllodes tumors are seen in female mammary glands, this case has a distinct histological appearance as will be described below.…”