Malignant cystosarcoma phylloides

Browder, William; McQuitty, James T.; McDonald, John C.

doi:10.1016/0002-9610(78)90236-2

Cited by 23 publications

(6 citation statements)

References 7 publications

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“…In more recent publications the presence of necrosis and increased vascularity within the tumour have ion. 3,7,[12][13][14][15][16] also been considered to be significant. 16," There is, however, no general agreement as to the classification of phyllodes tumours.…”

Section: Discussionmentioning

confidence: 99%

Phyllodes Tumours: A Clinicopathological Review of 30 Cases

Bennett

Khan

Freitas

et al. 1992

Australian and New Zealand Journal of Surgery

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Thirty cases of phyllodes tumour (cystosarcoma phyllodes) of the breast that presented to the Clinical Oncology Unit at Guy's Hospital were reviewed. Tumours were classified as benign, malignant or borderline according to the following histological criteria: mitotic rate, nuclear pleomorphism, stromal overgrowth and tumour margins. In 14 (46.5%) cases the tumours were considered histologically benign, in 11 (36.5%) malignant, and in five (17%) borderline. Recurrence was seen in a similar proportion of patients with tumours classified as benign (21 %) and malignant (18 %) according to histological criteria. Malignant lesions tended to recur earlier. Infiltrating tumour margins were noted in all patients and stromal overgrowth in all hut one in whom recurrence was observed. Risk of recurrence also appeared to he related to tumour size. Only one patient developed distant metastases and died of her disease. Because of treatment variation no conclusion can he made regarding optimal therapy but the importance of adequate clearance, either through wide excision or mastectomy, is emphasized for all phyllodes tumours irrespective of histological features.

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Section: Discussionmentioning

confidence: 99%

Phyllodes Tumours: A Clinicopathological Review of 30 Cases

Bennett

Khan

Freitas

et al. 1992

Australian and New Zealand Journal of Surgery

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“…On the other hand, West et a1 [21] obtained excellent control with just simple mastectomy, with or without axillary dissection, in patients with malignant lesions especially those with tumors measuring 5 cm or less. This procedure is also favored by several other authors [ 1,6,17,18,22,23]. Understandably, removal of the pectoral muscles would be justified if the tumor is very close to or actually invading these muscles [ 13,171.…”

Section: Discussionmentioning

confidence: 99%

Fatal metastatic cystosarcoma phyllodes in an adolescent female: Case report and review of treatment approaches

Turalba

El‐Mahdi

Ladaga

1986

Journal of Surgical Oncology

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The third reported case of fatal malignant cystosarcoma phyllodes in an adolescent female is described. The patterns of local recurrence and distant spread in this case, including the response to treatment, were similar to those reported in the first reported case in this age group. A review of the treatment recommendations for cystosarcoma phyllodes revealed that the surgical procedure of choice for the malignant variant has remained controversial, and the conclusions regarding the ineffectiveness of radiation and chemotherapy have been based on insufficient data handed down through the years. Our observations in this case and the information we have obtained from the literature have prompted us to recommend a multidisciplinary approach for malignant cystosarcoma phyllodes, particularly in young women, and we are calling for a multi-institutional study group to further investigate this disease.

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“…The most common sites for metastasis include the lungs, bone, liver, and distant lymph nodes. Skin involvement with tumor does not appear to be a predictor of metastasis [ 23 ]. While the use of chemotherapy and radiotherapy have shown promise in a few small trials, their role in the treatment of metastatic phyllodes tumors remains unproven.…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned before, the importance of this cut-off value has been disputed. There is a continuing debate that exists over the prognostic significance of tumor size [ 23 , 26 , 28 , 32 ]. Thus, appropriate cut off values for tumor size and associated prognosis have never been defined [ 18 ].…”

Section: Discussionmentioning

confidence: 99%