Malignant Degeneration of Benign Cystic Teratomas of the Ovary. A Collective Review of the Literature

Peterson, William F.

doi:10.1097/00006254-195712000-00001

Cited by 237 publications

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“…Malignant transformation, a well-recognized complication of MOT, occurs in less than 2% of cases (Kelley and Scully, 1961;Peterson, 1957). Some malignancies such as squamous cell carcinoma may arise from the epidermal component of the mature teratoma via carcinoma in situ (Klionsky et al, 1972) or from respiratory epithelium via squamous metaplasia/dysplasia/ carcinoma in situ (Hirakawa et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

“…Tumors of a non-germ cell phenotype involving mature ovarian teratomas (MOT) are well recognized and include squamous cell carcinoma (Peterson, 1957), adenocarcinoma (Peterson, 1957), melanoma (Liberati et al, 1998), malignant lymphoma (Seifer et al, 1986), thyroid carcinoma (Devaney et al, 1993), sarcoma (Peterson, 1957), and carcinoid tumor (Kelley and Scully, 1961). Morphologically, different preneoplastic stages have been detected in some of these tumors (Hirakawa et al, 1989;Klionsky et al, 1972), suggesting that these malignancies may have originated from benign teratomatous tissue.…”

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Teratomatous Genotype Detected in Malignancies of a Non-Germ Cell Phenotype

Devouassoux‐Shisheboran

Vortmeyer

Silver

et al. 2000

Laboratory Investigation

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SUMMARY:Originating from post-meiotic germ cells, mature ovarian teratomas (MOT) are genetically homozygous tumors within heterozygous hosts. MOT may be associated with malignant tumors of a non-germ cell phenotype (so-called malignant transformation). Based on the presence of in situ changes, some cases have been hypothesized to arise from teratomatous tissue. However, other malignancies associated with mature teratomas, such as sarcomas, may originate from either teratomatous elements or preexisting somatic ovarian tissue. Eight cases of MOT containing various histologic types of malignancy, including four squamous cell carcinomas, two sarcomas, one thyroid carcinoma, and one carcinoid tumor, were selected for study. Using selective tissue microdissection and PCR-based analysis of the extracted DNA, we compared the genotypic pattern of the mature teratomatous components to the associated malignant neoplasm with a random panel of highly informative genetic markers for different chromosomes. In all eight cases, genetic analysis of the malignant component revealed a homozygous genotype. In seven cases, the genetic profiles of mature teratomas and the associated malignant tumors were identical, suggesting a direct pathogenetic relationship between these lesions. In one case, the malignant component revealed homozygosity of different alleles compared with mature teratoma, suggesting independent teratomatous growth processes. This finding indicates that some ovarian malignancies of the non-germ cell phenotype arise in teratoma and fall into the spectrum of germ cell tumors. (Lab Invest 2000, 80:81-86).

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Teratomatous Genotype Detected in Malignancies of a Non-Germ Cell Phenotype

Devouassoux‐Shisheboran

Vortmeyer

Silver

et al. 2000

Laboratory Investigation

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“…On the other hand, for those rare ovarian teratomas with malignant elements, 39,40 malignant transformation occurs after the development of the teratoma ('post-teratomatous' malignant transformation). This applies to those dermoid cysts that develop malignant somatic neoplasms, most commonly squamous cell carcinoma 41,42 but rarely other types such as malignant melanoma, 43 adenocarcinoma 24,44 and various forms of sarcoma, 42 a phenomenon seen in 0.2-1.4% of mature ovarian teratomas. 39,40 The homozygous nature of the malignant elements in these cases, which is similar to the benign elements, supports derivation of the former from the latter, 17 as do similar cytogenetic changes in the two components.…”

Section: Dermoid and Epidermoid Cysts Of The Testismentioning

confidence: 99%

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

2005

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“…Alternatively, SCC can arise from endometriosis or Brenner tumor. SCC may also be seen as metastatic deposits from SCC elsewhere especially cervix, even though that tumor may have occurred many years previously 4 . The carcinoma begin at or near dermoid protuberance, continue to grow without clinical evidence, eventually penetrating full thickness of the wall, developing direct extension and malignant adhesions to the neighboring organs 5 .…”

Section: Discussionmentioning

confidence: 99%

Coexistence Of Squamous Cell CarcinomaWith Dermoid Cyst Of Ovary:A Case Report

Kumar¹,

Chhabra²,

Singh³

2013

Int J of Biomed & Adv Res

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Ovarian squamous cell carcinoma is a rare malignancy and the occurrence is attributable to malignant transformation of an existing ovarian dermoid cyst. The de novo occurrence of squamous cell carcinoma of the ovary, in the absence of an antecedent ovarian dermoid, is extremely rare. A 40- years- old female presented with pain and enlargement of abdomen since last 4 months. A mass was felt over right iliac fossa. Ultrasonography showed partly cystic and solid area in mass arising from ovary. A tooth- like structure was also seen. Dermoid cyst was the diagnosis offered. Laparotomy was performed. Ovarian mass with hair, a tooth and putty-like material was present. Solid white area with thickened wall was found. Histopathology confirmed the findings of dermoid cyst and the thickened area showed squamous cell carcinoma with areas showing keratinous and giant cell reaction which was also seen at the periphery of tumor areas. Left ovary was normal and no deposits of tumor were seen. Postoperative period was uneventful.

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Malignant Degeneration of Benign Cystic Teratomas of the Ovary. A Collective Review of the Literature

Cited by 237 publications

References 0 publications

Teratomatous Genotype Detected in Malignancies of a Non-Germ Cell Phenotype

Teratomatous Genotype Detected in Malignancies of a Non-Germ Cell Phenotype

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

Coexistence Of Squamous Cell CarcinomaWith Dermoid Cyst Of Ovary:A Case Report

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