Malignant distal femur tumors management in children, low cost innovations with affordable care in a tertiary care hospital, a cross sectional study

Abstract

Introduction Malignant musculoskeletal tumors in children are mostly comprised of Osteosarcoma and Ewing's sarcoma and distal femur is the most common site for primary bone tumors. This study examined the surgical management outcomes of pediatric patients (<18 years) presented in our setup with malignant distal femur tumors. Methodology We retrospectively reviewed the medical records of patients diagnosed with malignant sarcomas of distal femur and younger than 18 years of age who underwent limb salvage surgery during June 2009–June2017. Results There were 31 pediatric patients who had distal femur malignant tumors and out of them 20 patients were selected who underwent limb salvage as a primary surgery. The mean age (range) of patients was 11.90 (6–17) years. Seventeen had osteosarcoma and three had Ewing's sarcoma. In surgery all patients were offered reconstruction. Post-operative complications were observed in (50%) patients while other 50% patients had no complications. Wound infection, flap necrosis, broken plates with non-union and recurrence of disease were the reported complications. Revision surgery was performed in 10 patients out of 20 patients. Conclusion Salvage was the primary option in our surgery and revision surgery was performed in the cases due to complications. Small sample size was the limitation of the study.

Efficacy of Recombinant Human Endostatin plus Neoadjuvant Chemotherapy for Osteosarcoma and Its Influence on Serum VEGF and MMP-9 Levels

“…The onset age of OSA presents a bimodal distribution, most of which occurs in adolescents aged 10–14 and the elderly aged over 60 [ 3 ]. In adolescence, the disease often occurs in the long bone metaphysis of the extremities, such as the distal femur and the proximal tibia [ 4 , 5 ]. For the elderly, however, the predilection sites are diverse, which can also occur in the craniofacial region [ 6 ].…”

A comparison of osteoarticular allografts and allograft-prosthesis composites for reconstruction of the distal femur after resection of a bone tumour in childhood

“…1 Reconstruction of the femur after surgical resection of the mass is generally challenging, particularly in children. 1,2 Reconstruction with an expandable prosthesis provides immediate fixation and a return to weightbearing, and avoids the sizing concerns of an osteoarticular allograft. However, it is reported to have a high rate of complications, including stem loosening, implant failure, and problems with lengthening.…”