Malignant eccrine breast spiradenoma. A case report and literature review

Abstract

HighlightsEccrine spiradenomas are rare adnexal tumors of the skin. Malignant transformation of benign forms is even more unfrequent.We report a case of malignant breast eccrine spiradenoma diagnosed on the basis of breast cancer prevention programme.Imaging findings of these tumors have not been clearly demonstrated because of the rare incidence and lack of workup.The MRI findings of epidermal inclusion cysts and eccrine spiradenomas are different and so these findings might be used in making the differential diagnosis.

Spiradenoma of the breast and review of cases over 76-years

“…[8] Once malignant, spiradenocarcinomas have a metastasis rate of 50% spreading most commonly to the lymph nodes, bone, lungs, brain, and liver. [1,9] Adding to the difficulty of spiradenoma differentiation, a biopsy is required for diagnosis but can be recommended against in cases like epidermal cysts as nodule penetration can lead to leakage of cyst contents generating inflammation. [10] Imaging has been utilized as diagnostic aid.…”

“…Spiradenomas and epidermal inclusion cysts appear similar on ultrasound and mammography but have differentiating features on magnetic resonance imaging. [1] Both in ultrasound and mammograms, the lesions appear as a well-defined rounded mass with varying differences in density dependent on levels of debris within the epidermal inclusion cysts. There is only one report of MRI findings of spiradenomas of the breast by Lee et.…”

“…Most frequently, spiradenomas are encountered on the head and neck with only rare occurrences on the breast. [1,2] Development is most common between the ages of 20-40 years-old in both males and females (1:1 ratio) without racial preference. [1,3] Lesions often grow for 20-30 years before necessitating medical attention.…”

“…[1,2] Development is most common between the ages of 20-40 years-old in both males and females (1:1 ratio) without racial preference. [1,3] Lesions often grow for 20-30 years before necessitating medical attention. Only six cases of benign breast spiradenomas have been previously reported in the literature.…”

“…The characteristics of both tumors in all reported cases in the literature over the past 76 years are displayed in Table 1. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]…”