Malignant eccrine poroma. Case report and review of the literature

Abstract

A case of malignant eccrine poroma with lymph node metastases is described. The patient had a nodular growth of the right thigh 2 years before its first excision. Local recurrence in the scar occurred in 6 months, and by 8 months a right groin lymph node was involved. Subsequent skin nodules of the right thigh occurred over the next 12 months, associated with recurrent lymphedema of the leg. During several follow‐up visits, associated malignancies were found including villous adenoma of the ascending colon and renal cell carcinoma of the right kidney, both typical histologically and unrelated to the cutaneous tumor. Subsequently, left inguinal lymph node disease histologically identical to the skin tumor was found. Clinical and histologic findings were similar to the 31 previous cases reviewed. Electron microscopic examination confirmed the presence of a ductal structure consistent with eccrine duct and a crystalline membrane‐bound granule which may represent a specific marker for this rare tumor. The histologic features of this tumor are important to separate from other differential diagnostic possibilities which may have a quite different prognosis.

Multiple eccrine poromas in the setting of total body irradiation and immunosuppression

“…In addition, malignant transformation of eccrine poroma has been reported. 2,[19][20][21] This may be of particular concern in an immunocompromised patient, warranting careful monitoring by a dermatologist.…”

Eccrine Porocarcinoma Treated with Mohs Micrographic Surgery: A Report of Five Cases

“…[3][4][5]7 Just over 50% of patients with eccrine porocarcinoma are men. Since this first case report, eccrine porocarcinoma has been characterized as a rare, locally aggressive neoplasm with a high propensity to metastasize.…”

“…The first case of a malignant variant was subsequently reported and termed epidermotropic eccrine carcinoma. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Eccrine porocarcinoma is a locally aggressive tumor that has the potential to metastasize. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Eccrine porocarcinoma is a locally aggressive tumor that has the potential to metastasize.…”

Malignant eccrine poroma: report of three cases.

“…Some tumour nests showed central necrosis, with the surrounding cells showing some dyskeratosis and Bowenoid changes. This feature is mentioned in other reports,5 6 although Mehregan et a14 state that one of the features of malignant eccrine poroma is the lack of keratinisation. The presence of keratinisation in these tumours remains a controversial issue.…”