Malignant Endo-suprasellar Glioma: A Case Report and a Brief Review of the Literature

Abstract

Introduction: Malignant sellar gliomas are very rare phenomena. To date, only few cases of sellar and suprasellar glioblastomas have been reported, most of which originate from the optic nerve or optic chiasm. Case Presentation: We present a clinical case of malignant endo-suprasellar glioma, originating from the pituitary stalk, which was initially classified as a macroprolactinoma. Conclusions: Although malignant sellar gliomas can mimic the clinical, endocrinological, and radiological features of pituitary macroadenomas, rapid progression without appropriate hormonal activity suggests their diagnosis. Considering the high malignant potential of sellar glioblastomas, it is important to discuss the specific features of these tumors and to investigate the possibility of differential diagnosis in the preoperative stage, which can be useful for early selection of the treatment plan.

BRAF-mutated suprasellar glioblastoma mimicking craniopharyngioma: illustrative case

“… 4 A recently published report of a malignant sellar glioma involved endocrinological dysfunction similar to that of a pituitary macroprolactinoma. 5 We report a case of a glioblastoma resembling a benign craniopharyngioma managed with a bifrontal craniotomy for interhemispheric, transcallosal intraventricular access to the tumor. To our knowledge, it is the only report of a suprasellar glioblastoma resected through an interhemispheric approach as well as the only case of a suprasellar BRAF-positive, MGMT partially methylated glioblastoma.…”