Malignant Epithelial Tumors

Braun‐Falco, Otto; Plewig, Gerd; Wolff, Helmut H.; Winkelmann, R. K.

doi:10.1007/978-3-662-00181-3_57

Cited by 10 publications

(3 citation statements)

References 103 publications

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“…BCC has many different clinical and histological presentations 1 –6 . The clinical variants are nodular, ulcerating, cystic, pigmented, sclerodermiform and superficial types.…”

Section: Discussionmentioning

confidence: 99%

Polypoid basal cell carcinoma: a new clinicopathological variant

Megahed

1999

Br J Dermatol

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Basal cell carcinoma (BCC), the most common malignant neoplasm of the skin, has many different clinical and histological appearances. Four patients with a new distinctive form, polypoid BCC, are described. Polypoid BCC is clinically distinguished from other types of BCC by being pedunculated and having a stalk that connects it to the skin surface. Histologically, it is distinctive in that the tumour aggregations are restricted to the exophytic polypoid zone.

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“…BCC has many different clinical and histological presentations 1 –6 . The clinical variants are nodular, ulcerating, cystic, pigmented, sclerodermiform and superficial types.…”

Section: Discussionmentioning

confidence: 99%

Polypoid basal cell carcinoma: a new clinicopathological variant

Megahed

1999

Br J Dermatol

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“…GBCC has also been defined as a tumor 10 em or larger in diameter (1,7). The calculation of the involved area according to the formula 1t r 2 was even proposed in order to more accurately define the size of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Giant Basal Cell Carcinomas: Report of Four Cases and Considerations

Betti

Inselvini

Moneghini

et al. 1997

The Journal of Dermatology

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“…BCC is a slowly growing tumor, which rarely metastasizes and therefore is termed locally malignant. The incidence of BCC has been rising steadily in Caucasians all over the world and has doubled in Europe over the past 15 years (10).…”

Section: Introductionmentioning

confidence: 99%

The contribution of melanocortin 1 receptor gene polymorphisms and the agouti signalling protein gene 8818A>G polymorphism to cutaneous melanoma and basal cell carcinoma in a Polish population

Brudnik

Branicki

Wojas‐Pelc

et al. 2009

Experimental Dermatology

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In this study, we assessed the role of melanocortin-1 receptor (MC1R) and agouti signalling protein (ASIP) polymorphisms in cutaneous melanoma and basal cell carcinoma (BCC) development in a Polish population. We enrolled 108 patients with skin malignant melanoma (MM) and 102 patients with BCC. The control group consisted of 93 non-red haired patients, without history of skin cancers and 30 healthy individuals with red hair colour (RHC) phenotype. The complete MC1R exon was sequenced and the A8818G polymorphism of the ASIP gene was analysed using the SnaPshot protocol. Selected MC1R mutations were additionally examined using a convenient minisequencing assay. The study confirmed the important role of MC1R R variants in determining physiological variation in hair and skin colour. Our data show that individuals with R mutations had a 3.7-fold increase in melanoma risk and a 3.3-fold increase in BCC risk. Especially, variant R151C significantly increased the risk of both MM and BCC. The studied ASIP polymorphism was found not to be associated with MM or BCC. Stratified analysis showed that the association between MC1R mutations and the risk of MM and BCC was not significantly influenced by subjects' pigmentation characteristics or the 8818G ASIP variant. Further research is necessary, especially involving analysis of interactions between variation in MC1R and other genes, to find out if analysis of MC1R polymorphisms could be of any importance for skin cancer prevention.

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Malignant Epithelial Tumors

Cited by 10 publications

References 103 publications

Polypoid basal cell carcinoma: a new clinicopathological variant

Polypoid basal cell carcinoma: a new clinicopathological variant

Giant Basal Cell Carcinomas: Report of Four Cases and Considerations

The contribution of melanocortin 1 receptor gene polymorphisms and the agouti signalling protein gene 8818A>G polymorphism to cutaneous melanoma and basal cell carcinoma in a Polish population

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