Malignant external otitis with extensive cranial neuropathy but no facial paralysis

Kondziella, Daniel; Skagervik, Ina

doi:10.1007/s00415-006-0516-1

Cited by 7 publications

(1 citation statement)

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“…We suggest that involvement of the jugular foramen and petrous apex are checkpoints for predicting the outcome and the course of disease for MEO from imaging studies. However, Kondziella and Skagervik [ 20 ] reported an atypical presentation of MEO showing extensive cranial neuropathy in the absence of facial paralysis. Therefore, the disease does not always spread via the pathway described above.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Prognostic Factors in Malignant External Otitis

Lee

Seon

et al. 2017

Clin Exp Otorhinolaryngol

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Objectives Malignant external otitis (MEO) is a potentially fatal infection of the external auditory canal, temporal bone, and skull base. Despite treatment with modern antibiotics, MEO can lead to skull base osteomyelitis. Until now, there have been few studies on the prognostic factors of MEO.Methods We performed a retrospective study to identify prognostic factors of MEO, and a meta-analysis of other articles investigating MEO. On the basis of disease progression the 28 patients in our study were divided into ‘controlled’ and ‘uncontrolled’ groups, consisting of 12 and 16 patients, respectively. We identified three categories of prognostic factors: those related to patient, disease, and treatment. We compared these prognostic factors between the controlled and uncontrolled groups.ResultsIn our study, the duration of diabetes mellitus (DM), presence of inflammatory markers (C-reactive protein and erythrocyte sedimentation rate), and computed tomography or magnetic resonance imaging findings influenced the prognosis of MEO. In contrast, prognosis was unrelated to age, gender, mean glucose level, hemoglobin A1c level, pathogen, comorbidity, or cranial nerve involvement. No factor related to treatment modality was correlated with prognosis, such as surgery, steroid therapy, or interval to the first appropriate treatment. Cranial nerve involvement has been proven to be associated with disease progression, but the relationship between cranial nerve involvement and the prognosis of MEO remains controversial. As a part of this study, we conducted a meta-analysis of cranial nerve involvement as a prognostic factor of MEO. We found that cranial nerve involvement has a statistically significant influence on the prognosis of MEO.Conclusion We found that glycemic control in diabetes mellitus, cranial nerve involvement, and the extent of disease determined from various imaging modalities influence the prognosis of MEO. We suggest that significant prognostic factors should be monitored to determine the prognosis of patients with MEO.

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Section: Discussionmentioning

confidence: 99%