Malignant extra-adrenal pelvic paraganglioma in a paediatric patient

Cao, Gabriel; Méndez, Julián; Navacchia, Daniel

doi:10.3332/ecancer.2017.761

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…The 2014 Endocrine Society clinical practice guidelines for pheochromocytoma and paraganglioma suggest that 10-17% of pheochromocytomas and paragangliomas are malignant, of which the proportion of paragangliomas is higher [5]. Malignant extra-adrenal paraganglioma is rare and reported to be less than 3%, of which nearly 75% are sporadic and 25% are hereditary [9]. Malignant tumors are mostly metastases or spread to organs without chromaffin tissue [10].…”

Section: Discussionmentioning

confidence: 99%

A young patient with heart failure was diagnosed with extra-adrenal paraganglioma: a case report

Zhang

Cao

Yan

et al. 2022

BMC Cardiovasc Disord

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Background We present a case of pelvic paraganglioma that presented with heart failure as the primary symptom. Case presentation A 35-year-old man was admitted to hospital due to heart failure. Contrast-enhanced pelvic CT showed mass shadows in the posterior wall of the bladder and multiple enlarged lymph nodes in the retroperitoneal area. Ultrasound-guided puncture was performed, and the pathologic diagnosis was extra-adrenal paraganglioma. The patient refused any chemotherapy and died within six months of diagnosis. Conclusion The possibility of neuroendocrine-related tumors, for example paragangliomas, should be considered in young patients with heart failure, especially those with concomitant hypertension and diabetes.

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Section: Discussionmentioning

confidence: 99%

A young patient with heart failure was diagnosed with extra-adrenal paraganglioma: a case report

Zhang

Cao

Yan

et al. 2022

BMC Cardiovasc Disord

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show abstract

“…In summary, our study improves upon previous reviews, which was dated and focalized mainly on bladder PGL . For example, Tsai et al includes one study dating back to 1911, and then eleven studies between 1989 and 2000 [17], while Beilan et al [85] included 80 studies between 1980 and 2012; therefore, we offer a more updated view for analyzing contemporary outcomes. Our study used a multitude of demographics to depict the disease process of pelvic and bladder PGL, including presenting signs and symptoms, tumor functionality and size, treatment modality, and outcomes.…”

Section: Discussionmentioning

confidence: 99%

Pelvic and Bladder Catecholamine-Producing Tumors A Review of the Literature

Petramala

Bisogni

Olmati

et al. 2019

Preprint

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Purpose . Starting from the description of two interesting cases, we wondered to review the literature on pelvic and bladder paragangliomas (PGLs) in order to illustrate clinical characteristics and current management, lightening the needed of a prompt diagnosis to avoid the onset of several complications. Although PGLs may arise at any site where physiologically chromaffin tissue exists, pelvic origins are not frequent (less than 2%), and the most common localization is the retroperitoneal space, whereas bladder PGLs account for less than 0.06% of all bladder neoplasms and less than 1% of all PGLs. Methods . We herein performed a brief review of the literature about pelvic PGLs in the PubMed library, conducted according to the PRISMA statement, including studies published from 1954 to 2019. We also discuss clinical presentation, morphologic appearance, and management of two cases of pelvic PGL, both of them characterized by an history of paroxysmal high blood pressure episodes uncontrolled by antihypertensive therapy associated with disabling symptoms, not clearly understood for many years. Results . Overall, we evaluated 108 case reports. The majority were females, presenting typical signs and symptoms, such as arterial hypertension (54.2%), hematuria (35.1%), and headache (33.6%). After treatment, the clinical and biochemical remission was evident in only 55% of analyzed cases. Conclusions . For their singular localization, pelvic and bladder PGLs often might be misdiagnosed. The significant delay in the proper treatment could be responsible for the relative low percentage of complete clinical and biochemical remission.

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“…In summary, our study improves upon previous reviews, which was dated and focalized mainly on bladder PGL . For example, Tsai et al includes one study dating back to 1911, and then eleven studies between 1989 and 2000 [17], while Beilan et al [85] included 80 studies between 1980 and 2012; therefore, we offer a more updated view for analysing contemporary outcomes. Our study used a multitude of demographics to depict the disease process of pelvic and bladder PGL, including presenting signs and symptoms, tumor functionality and size, treatment modality, and outcomes.…”

Section: Discussionmentioning

confidence: 99%

Pelvic and Bladder Catecholamine-Producing Tumors A Review of the Literature

Petramala

Bisogni

Olmati

et al. 2019

Preprint

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Background Although PGLs may arise at any site where physiologic paraganglionic tissue exists, pelvic origins are not frequent (about 2%), and the most common localization is the retroperitoneal space, whereas bladder PGLs account for less than 0.06% of all bladder neoplasms and less than 1% of all PGLs. Starting from the description of two interesting our cases, we wondered to review the literature on pelvic and bladder paragangliomas (PGLs) with the aim of illustrating clinical characteristics and current management, and enlightening the needed of a prompt diagnosis to avoid the onset of several complications.Methods We herein performed a brief review of the literature about pelvic PGLs in the PubMed library, conducted according to the PRISMA statement, including studies published from 1954 to 2019. We also discuss clinical presentation, morphologic appearance, and management of two cases of pelvic PGL, both of them characterized by a history of paroxysmal high blood pressure episodes uncontrolled by antihypertensive therapy associated with disabling symptoms, misdiagnosed for many years.Results Overall, we evaluated 108 case reports. The majority were females, presenting typical signs and symptoms, such as arterial hypertension (54.2%), hematuria (35.1%), and headache (33.6%). After treatment, the clinical and biochemical remission was showed in only 55% of analyzed cases.Conclusions For their singular localization, pelvic and bladder PGLs often might be misdiagnosed. The resulting delay in the proper treatment could be responsible for the relative low percentage of complete clinical and biochemical remission.

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Malignant extra-adrenal pelvic paraganglioma in a paediatric patient

Cited by 5 publications

References 11 publications

A young patient with heart failure was diagnosed with extra-adrenal paraganglioma: a case report

A young patient with heart failure was diagnosed with extra-adrenal paraganglioma: a case report

Pelvic and Bladder Catecholamine-Producing Tumors A Review of the Literature

Pelvic and Bladder Catecholamine-Producing Tumors A Review of the Literature

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