Malignant fibrous histiocytoma arising from renal capsule: An extremely rare entity

Bairwa, Shilpa; Sangwaiya, Ashok; Ansari, Mariyam; Jindal, Ankur; Singla, Sapna; Yadav, Ajay

doi:10.4103/ijpm.ijpm_810_15

Cited by 4 publications

(5 citation statements)

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“…The diagnosis of UPS mainly depends on path morphology and immunohistochemistry. UPS is characterized by a typical immunopositive response to CD68 and vimentin, which distinguishes it from other renal sarcomas (Bairwa et al 2017). The CT scan of renal UPS showed a large solid tumor, usually with necrotic or hemorrhagic areas and adjacent invasion, and the attenuation on enhanced CT scan was slightly higher than that of skeletal muscle (Karaosmanoğlu et al 2015).…”

Section: Discussionmentioning

confidence: 97%

Inflammatory undifferentiated pleomorphic sarcoma of the kidney with obstinate cough and fever as the first symptom: a case report and literature review

Ang

Zhang

et al. 2021

All Life

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Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive cancer that most commonly occurs in the extremities and trunk but is extremely rare in the kidney. This study reports a 60year-old woman with obstinate cough and fever as the first symptoms and an initial diagnosis of inflammatory lung disease. However, none of the symptoms improved after one month of treatment. A repeated chest computed tomography (CT) scan suggested a huge renal mass in the left kidney; therefore, a radical nephrectomy was finally performed in the urology department. And the postoperative pathological examinations revealed UPS. Interestingly, the bothersome symptoms of the patient magically disappeared on the 2nd day after the surgery. During a follow-up of 32 months, there was no sign of recurrence. We found that early diagnosis together with thorough surgical treatment is currently the most effective approach to prolong the survival time of patients. In addition, postoperative radiotherapy and chemotherapy could be alternative options to benefit patients.

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Section: Discussionmentioning

confidence: 97%

Inflammatory undifferentiated pleomorphic sarcoma of the kidney with obstinate cough and fever as the first symptom: a case report and literature review

Ang

Zhang

et al. 2021

All Life

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“…Neoplasms originating in the renal capsule are very rare. Among fibrohistiocytic tumors, BFH [5] and malignant fibrous histiocytoma(MFH) [6, 7] have been described in the literature. Shoji K. et al first reported a case of BFH originating in the renal capsule in 1992 [5], measuring 6 × 4.5 × 6 cm.…”

Section: Discussionmentioning

confidence: 99%

“…Retroperitoneum or kidney origin accounts for 12–14% of all cases [14]. There are few reported cases of MFH definitely arising from the renal capsule [6, 7, 15, 16]. The histology characters of MFH were groups of histiocytes and pleomorphic giant cells with large nuclei and moderate mitotic activity.…”

Section: Discussionmentioning

confidence: 99%

A huge benign fibrous histiocytoma arising from the renal capsule: report of a case

Sun

Wang

et al. 2019

BMC Nephrol

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Background Neoplasms originating in the renal capsule are very rare. Benign fibrous histiocytoma(BFH) most commonly occurs in the dermis and subcutis, few cases of this tumor appear in the renal capsule. In particular, BFH larger than 20 cm are scarce. Here we report a rare huge one measuring 23 × 13 × 7 cm. Case presentation We report a 64-year-old man who presented with a few-months history of dull pain in the right groin. The tumor had its point of origin in the renal capsule which is a rare condition. Histologically, the tumor was composed of intersecting fascicles of fibroblastic cells forming a “storiform” pattern. Immunohistochemical studies were also performed, ultimately leading to the diagnosis of BFH. The patient was treated with radical nephrectomy. No recurrence was detected 4 months after surgery. Conclusions BFH arising from the renal capsule was very rare. In particular, the case of more than twenty centimeters is extremely rare. The clinical presentation of renal BFH might be only a mass. However, differential diagnosis from renal cell carcinoma proved to be impossible before surgical intervention. It is difficult to diagnose only by means of histopathology, but the immunohistochemical method can provide a clear and definite diagnosis.

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“…Histologically, MFH is divided to five types, including storiform-pleomorphic, myxoid, giant cells, inflammatory and angiomatoid [9, 29, 30], among which the storiform-pleomorphic type is the most usual and commonly high grade variant of MFH [24, 31]. MFH is characterized by typical immunepositivity for CD68, vimentin and alfa-1-antitrypsin that can differentiate it from other renal sarcomas [29] and among these markers, CD68 has become as a specific histological marker for confirming MFH [32]. Our case was also consistent with storiform arrangement of spindle cells admixed with mononuclear to multinucleated giant cells and histiocytic cells known as a histological hallmark of MFH [33] and the diagnosis was confirmed by immunohistological staining.…”

Section: Discussionmentioning

confidence: 99%

A rare case of primary malignant fibrous histiocytoma: a sarcoma of the kidney

et al. 2019

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Background Primary malignant fibrous histiocytoma of the kidney (MFH) is an extremely rare tumor which is indistinguishable from its’ mimics in particular renal cell carcinoma (RCC) by clinical features and preoperative imaging evaluation. Due to its high predilection to local recurrence and distant metastases, early diagnosis has great value. Case presentation Herein, we describe a 62 year-old man with a 3-month history of abdominal discomfort and a palpable right loin mass whom computerized tomography (CT) showed a large heterogeneous solid mass in the right kidney. With the suspicious to RCC; the patient underwent radical nephrectomy. However, histopathological report revealed pleomorphic-storiform malignant fibrous histiocytoma. Immunohistochemistry study was also confirmed the diagnosis of MFH. Six month follow up showed no evidence of any recurrence. Conclusions The therapeutic options for MFH differ from other renal tumors, hence histopathology and immunohistochemistry studies are required to establish a definite diagnosis of the disease. Despite of progress made in clinical studies and advances in diagnostic modalities, early diagnosis of MFH has not achieved yet. Further studies and accumulated experience with renal MFH are required to determine the approach to prolong survival in selected cases along with management and prognostic factors of such tumors.

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Malignant fibrous histiocytoma arising from renal capsule: An extremely rare entity

Cited by 4 publications

References 0 publications

Inflammatory undifferentiated pleomorphic sarcoma of the kidney with obstinate cough and fever as the first symptom: a case report and literature review

Inflammatory undifferentiated pleomorphic sarcoma of the kidney with obstinate cough and fever as the first symptom: a case report and literature review

A huge benign fibrous histiocytoma arising from the renal capsule: report of a case

A rare case of primary malignant fibrous histiocytoma: a sarcoma of the kidney

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