Malignant fibrous histiocytoma: Database review suggests a favorable prognosis in the head and neck

Borucki, Robert; Neskey, David M.; Lentsch, Eric J.

doi:10.1002/lary.26909

Cited by 15 publications

(10 citation statements)

References 18 publications

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“…For smaller tumours with no evidence of metastasis, surgical extirpation alone may be the definitive treatment [16,23]. Our study showed that tumour size > 10 cm was a prognostic factor for both poor OS and CSS, which was consistent with a recent study [16].…”

Section: Survival By Tumour Sizesupporting

confidence: 91%

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Malignant fibrous neoplasms of long bones: analysis of the surveillance, epidemiology, and end results database from 1973 to 2015

Huang

Hong

Meng

et al. 2020

BMC Musculoskelet Disord

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Background: Malignant fibrous neoplasms (MFN) of long bones are rare lesions. Moreover, the prognostic determinants of MFN of long bones have not been reported. This study aimed to present epidemiological data and analyse the prognostic factors for survival in patients with MFN. Materials and methods: The Surveillance, Epidemiology, and End Results (SEER) programme database was used to screen patients with malignant fibrous neoplasms (MFN) of long bones from 1973 to 2015, with attention to fibrosarcoma, fibromyxosarcoma, periosteal fibrosarcoma and malignant fibrous histiocytoma. The prognostic values of overall survival (OS) and cancer-specific survival (CSS) were assessed using the Cox proportional hazards regression model with univariate and multivariate analyses. The Kaplan-Meier method was used to obtain OS and CSS curves. Results: A total of 237 cases were selected from the SEER database. Malignant fibrous histiocytoma was the most common form of lesion in long bones. Multivariate analysis revealed that independent predictors of OS included age, stage, tumour size and surgery. Age, stage, tumour size and surgery were also independent predictors of CSS. Additionally, the most significant prognostic factor was whether metastasis had occurred at the time of initial diagnosis. Conclusion: Among patients with MFN of long bones, age (> 60 years), tumour size (> 10 cm), distant stage, and non-surgical treatment are factors for poor survival.

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Section: Survival By Tumour Sizesupporting

confidence: 91%

“…These tumours can infiltrate adjacent tissues and metastasize distally [13][14][15][16][17][18][19]. However, the outcome and prognosis of patients with MFN of long bones have not been reported because of its rarity.…”

Section: Discussionmentioning

confidence: 99%

Malignant fibrous neoplasms of long bones: analysis of the surveillance, epidemiology, and end results database from 1973 to 2015

Huang

Hong

Meng

et al. 2020

BMC Musculoskelet Disord

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“…Compared with tumors that occurred in the extremities, trunk tumors showed no statistically significant difference for OS, LRFS, and MFS in our cohort. However, one report21 showed that tumor located in the head and neck had a favorable prognosis due to a smaller size and a lower grade contrast with Sabesan, who reported that head and neck tumor would have a poor outcome because of the inadequate resection 22. To sum up, the tumor size, grade, depth, or important structures involvement may play a crucial role in patient prognosis.…”

Section: Discussionmentioning

confidence: 98%

<p>Undifferentiated Pleomorphic Sarcoma: Long-Term Follow-Up from a Large Institution</p>

Chen

Huang

Luo

et al. 2019

CMAR

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PurposeOur study aimed to describe the clinical features of undifferentiated pleomorphic sarcoma (UPS) and identify the predictors of poor outcomes.Patients and methodsThe clinicopathological variables and treatment strategies of 100 UPS patients who underwent surgical resections at a single institution between November 2004 and July 2016 were reviewed. Kaplan–Meier and Cox regression method were conducted for survival analysis.ResultsThe median follow-up time was 94 months (range, 1.5–154 months). R0 resection was applied for 72 cases, and the median tumor size was 5.75cm (range, 1–30cm). Tumor grades of 45 patients were intermediate grade (G2), and 54 patients were with advanced stage (stage III/IV). Twenty-seven patients presented with tumors involving important structures, in which the nerve was the most frequently invaded structure (n=12). During the follow-up, 40 patients suffered from postoperative local recurrence, and distant metastasis was observed in 25 patients which mainly metastasized to the lung (n=14). The 5-year OS rate, 5-year LRFS rate, and 5-year MFS rate was 53%, 55%, and 70%, respectively. Multivariate analysis revealed that tumor presentation, tumor size, and important structures involved (p=0.033, p=0.004, and p=0.033, respectively) were independent prognostic factors associated with OS. Meanwhile, age, resection quality and tumor grade were independent prognostic factors for LRFS (p=0.033, p=0.045, and p=0.007, respectively) and tumor depth was significantly associated with MFS (p=0.050) in multivariate analysis.ConclusionPrimary treatment of UPS should be conducted by experts in large sarcoma center. Wide surgical margin provides sufficient control of the disease recurrence.

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“…Head and neck malignant fibrous histiocytoma present at a smaller size and lower grade, likely due to earlier presentation in this region. Because of this, head and neck malignant fibrous histiocytoma represents a favorable survival prognosis compared with extremity disease [65,66].…”

Section: Summary Of Evidencementioning

confidence: 99%

Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature

Zhurakivska

Troiano

Montella

et al. 2020

IJERPH

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Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. For therapeutic purposes, complete exeresis of the lesion (macroscopic and microscopic) is performed because they have frequent recurrences. As for complementary therapy in addition to surgery, neither radiotherapy nor chemotherapy have been shown to reduce the risk of death related to the disease. Often patients complain of a swelling that grows in a short period of time. It is quite common for patients to report trauma in the area, which is not the cause, but rather the event that allows diagnosis. The mass usually does not cause pain unless it compresses an adjacent nerve structure. The aim of this study is to systematically review the scientific literature in order to identify the most recent studies concerning malignant fibrous histiocytomas localized in oral soft tissues and report their main data. The main outcomes of this study concern the immunohistochemical, molecular, and clinical aspects of this pathology. A systematic review of articles in the electronic databases pubmed, Scopus, and Web of Science was performed. After the selection process, 11 studies met the inclusion criteria and were included in the review. The mean age of the patients was 50.8 years old. The lesions affected various parts of the oral cavity, showing predominantly storiform–pleomorphic patterns. All cases except one were treated with surgical resection and radiation therapy. Although some data emerged from this review, they remain limited to a few case reports. Further studies are necessary in order to standardize the approach to patients affected by oral malignant fibrous histiocytoma (MFH).

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Malignant fibrous histiocytoma: Database review suggests a favorable prognosis in the head and neck

Abstract: 4. Laryngoscope, 128:885-888, 2018.

Cited by 15 publications

References 18 publications

Malignant fibrous neoplasms of long bones: analysis of the surveillance, epidemiology, and end results database from 1973 to 2015

Malignant fibrous neoplasms of long bones: analysis of the surveillance, epidemiology, and end results database from 1973 to 2015

<p>Undifferentiated Pleomorphic Sarcoma: Long-Term Follow-Up from a Large Institution</p>

Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature

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