Malignant fibrous histiocytoma in a dog: a case report

Kiran, M. M.; Karaman, Mehmet Gökşin; Hatıpoğlu, Fatih; Koc, Y.

doi:10.17221/5665-vetmed

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…The malignant fibrous histiocytomas has a nodular, multinodular and firm macroscopic appearance. Cut surfaces of tumors has non specific appearance such as necrosis, not encapsulated and with pale white color (Datarkar and Hazare, 2009;Kiran et al, 2005;Turk, 2010). The macroscopic findings determined in this case study were found to be in parallel with those reported in previous case studies.…”

Section: Discussionsupporting

confidence: 81%

“…Histopathologically it was observed that the tumour contained a large number of giant cells with 8-12 nuclei and that the tumour cells were histiocyte-like. Malignant fibrous histiocytomas generally have a superficial location, are in the form of small masses, and can be easily removed by surgery (Guccion and Enzinger, 1972;Hamir, 1989;Kiran et al, 2005). In contrast to available literature reports, the tumour in this case study was observed to have infiltrated into the deeper layers.…”

Section: Discussioncontrasting

confidence: 62%

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Fine-Needle Aspiration Cytology of Malignant Fibrous Histiocytoma (Giant Cell Type) in an Angora Cat

Yumuşak

Çalışkan

Kutsal

2018

Harran Üniversitesi Veteriner Fakültesi Dergisi

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This case study presents the radiological, cytopathological and histopathological description of the giant cell type of a malignant fibrous histiocytoma on the back of a 9-year-old female Angora cat. Latero-lateral and ventro-dorsal thoracic radiographs was taken to evaluate invasion. Radiologically the mass was invasive but had not invaded the bone. Under general anaesthesia, cytopathological samples were taken from the tumour, using the Fine-Needle Aspiration Cytology (FNAC) technique, and were later stained with May-Grünwald Giemsa solution. The surgically extracted biopsy sample was subjected to routine tissue processing and stained with Haematoxylin-Eosin (HE). The biopsy material was 8x6x6 cm and 95 g, was covered by skin, multilobulary appearance and hard consistency. Cross-sections was greyish white and necrotic appearance. Cytopathological examination revealed the presence of numerous histiocyte-or fibrocyte-like cells of anaplastic character and pleomorphic shape, which were associated with giant cells with multiple nuclei and a broad and vacuolar cytoplasm. Histological examination demonstrated the presence of histiocyte-like atypical cells arranged in the form of swirls and extending in various directions, or numerous giant cells with 8 to 12 nuclei and a broad cytoplasm situated in between connective tissue cells.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 62%

Fine-Needle Aspiration Cytology of Malignant Fibrous Histiocytoma (Giant Cell Type) in an Angora Cat

Yumuşak

Çalışkan

Kutsal

2018

Harran Üniversitesi Veteriner Fakültesi Dergisi

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“…MFH is associated with a rapid clinical progression, grave prognosis, and usually fatal outcome [ 4 ]. Although MFH is the most common type soft tissue sarcoma reported in humans, it has been uncommonly described in veterinary medicine [ 5 ]. A previous survey of the types of tumors occurring in dogs found that MFH comprised only 0.34% of all reported tumors [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Splenic malignant fibrous histiocytoma with concurrent hypertension and epistaxis in an Alaskan malamute dog

Kim

Lee

et al. 2018

BMC Vet Res

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BackgroundMalignant fibrous histiocytoma has been uncommonly described in dogs. Several extranasal neoplasias have been reported to result hypertensive epistaxis. There are, however, no published case reports of extranasal malignant fibrous histiocytoma with concurrent hypertension and epistaxis in dogs.Case presentationA 10-year-old dog presented with a spontaneous massive epistaxis persisting for 5 days. The dog exhibited unstable hypertension, which was considered as a cause of epistaxis. The complete blood count, prothrombin time, and activated partial thromboplastin time were within the reference limits, and other systemic examination showed no abnormalities except for a splenic mass occupying more than one third of the abdomen. Histologic examination of the resected spleen revealed the characteristic features of a malignant fibrous histiocytoma. One week after splenectomy, the hypertension and epistaxis resolved clinically and did not recur on the 5-month follow-up.ConclusionsThe dog’s blood pressure and epistaxis normalized after malignant fibrous histiocytoma resection suggesting that hypertensive epistaxis may be a rare manifestation of canine malignant fibrous histiocytoma.

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“…UPS in animals has been reported previously in various species including dogs, cats, pigs, cattle, and horses. The lesions involved were of the spleen, head, skin, subcutaneous tissues, ileum, and digits [2,3,6,[10][11][12][13][14][15][16][17][18]. Extradural cases are rare in animals despite their commonness in human literature [19,20].…”

Section: Discussionmentioning

confidence: 99%

Multiple Undifferentiated Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma) with Extradural Involvement in a 7-Year-Old Labrador Retriever

Kim

Shin²,

Kim

et al. 2021

Veterinary Sciences

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A 7-year-old castrated male Labrador retriever was referred for evaluation of progressive hind limb paresis of 4 weeks’ duration. On computed tomography and magnetic resonance imaging examination, masses were found in several regions including the lung, right kidney, and peritoneum. Additionally, an extradural mass at the region of T13–L1 was identified, which is assumed to related to the chief complaint, progressive hind limb paresis. With the consent of the owner, a dorsal laminectomy was performed to remove the mass and surrounding tissues for the palliation of the hind limb paresis. Hematoxylin and eosin staining and immunohistochemical examination revealed the mass to be consistent with an undifferentiated (high-grade) pleomorphic sarcoma. The patient presented with recurrence of the hind limb paresis, respiratory discomfort, and urinary incontinence. The owner declined treatment and the dog was euthanized. Systemic metastasis was confirmed on postmortem microscopic examination. To the authors’ knowledge, this is the first report describing multiple undifferentiated high-grade pleomorphic sarcoma with extradural involvement developing into the vertebral canal through the intervertebral space, resulting in spinal damage, in a dog.

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Malignant fibrous histiocytoma in a dog: a case report

Abstract: ABSTRACT:In this report, a case of malignant fibrous histiocytoma involving skin, lungs, kidneys, pancreas and mediastinal lymph node was described. Microscopically, the tumor classified as storiform-pleomorphic type malignant fibrous histiocytoma.

Cited by 6 publications

References 15 publications

Fine-Needle Aspiration Cytology of Malignant Fibrous Histiocytoma (Giant Cell Type) in an Angora Cat

Fine-Needle Aspiration Cytology of Malignant Fibrous Histiocytoma (Giant Cell Type) in an Angora Cat

Splenic malignant fibrous histiocytoma with concurrent hypertension and epistaxis in an Alaskan malamute dog

Multiple Undifferentiated Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma) with Extradural Involvement in a 7-Year-Old Labrador Retriever

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