Malignant fibrous histiocytoma, now referred to as Undifferentiated Pleomorphic Sarcoma: A Case Report of an unexpected histology of a subcutaneous lesion

Seomangal, Karishma; Mahmoud, Nezar; McGrath, Jonathan

doi:10.1016/j.ijscr.2019.06.035

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Here are to be highlighted, the most common histological grading system for STS is the French Federation Natinale des centres de Lutte Cotre le Cancer grading system which on the basis of the following three items: degree of differentiation, mitotic activity, and necrosis. 9 Unfortunately, this information is missing for the vast majority of UPS patients in the SEER database, so we utilized the histological grade based on the degree of differentiation instead.…”

Section: Methodsmentioning

confidence: 99%

“…Undifferentiated pleomorphic sarcoma is normally treated by extensive surgical resection and adjuvant radiotherapy, with adjuvant chemotherapy considered for high-grade tumors. 9 Accurate prognosis is critical for treatment decisions. At present, the prognostic tool most commonly used for UPS is the American Joint Committee on Cancer (AJCC) staging system for STS.…”

Section: Introductionmentioning

confidence: 99%

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Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Zhao

Xue

et al. 2021

Cancer Control

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Introduction The purpose of this study was to construct and validate a nomogram for predicting cancer-specific survival (CSS) in undifferentiated pleomorphic sarcoma (UPS) patients at 3, 5, and 8 years after the diagnosis. Methods Data for UPS patients were extracted from the SEER (Surveillance, Epidemiology, and End Results) database. The patients were randomly divided into a training cohort (70%) and a validation cohort (30%). The backward stepwise Cox regression model was used to select independent prognostic factors. All of the factors were integrated into the nomogram to predict the CSS rates in UPS patients at 3, 5, and 8 years after the diagnosis. The nomogram’ s performance was then validated using multiple indicators, including the area under the time-dependent receiver operating characteristic curve (AUC), consistency index (C-index), calibration curve, decision-curve analysis (DCA), integrated discrimination improvement (IDI), and net reclassification improvement (NRI). Results This study included 2,009 UPS patients. Ten prognostic factors were identified after analysis of the Cox regression model in the training cohort, which were year of diagnosis, age, race, primary site, histological grade, T, N, M stage, surgery status, and insurance status. The nomogram was then constructed and validated internally and externally. The relatively high C-indexes and AUC values indicated that the nomogram has good discrimination ability. The calibration curves revealed that the nomogram was well calibrated. NRI and IDI values were both improved, indicating that our nomogram was superior to the AJCC (American Joint Committee on Cancer) system. DCA curves demonstrated that the nomogram was clinically useful. Conclusions The first nomogram for predicting the prognosis of UPS patients has been constructed and validated. Its usability and performance showed that the nomogram can be applied to clinical practice. However, further external validation is still needed.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Zhao

Xue

et al. 2021

Cancer Control

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“…1 An undifferentiated pleomorphic sarcoma usually occurs in patients between 32 and 80 years old with a male predominance. 6 Although patients usually present late with metastasis, most frequently to lungs, primary pulmonary undifferentiated pleomorphic sarcoma arising in the lung is rare. Patients may be asymptomatic or are diagnosed with cough, dyspnea, or chest pain.…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Undifferentiated Pleomorphic Sarcoma: A Rare Malignant Lung Tumor

Kang

Heo

et al. 2021

Journal of Investigative Medicine High Impact Case Reports

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We report a case of a 56-year-old man with persistent right upper lobe cavitary mass. A chest computed tomography scan showed about 4-cm-sized mass with internal low attenuation and peripheral enhancement in right upper lobe apical segment. The lesion size increased over 1 month. Right upper lobectomy was performed with the intention to treat the lesion. Pathological examination showed primary pulmonary undifferentiated pleomorphic sarcoma. We describe this rare lung disease to remind that primary pulmonary undifferentiated pleomorphic sarcoma could be the differential diagnosis of pulmonary cavitary mass lesions.

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“…The neoplasm typically presents in the latter decades of life with a slight male predominance [ 4 ]. UPS has been classified into five subtypes, including storiform/pleomorphic, myxoid, giant cell, inflammatory, and angiomatoid; the most common subtype is storiform/pleomorphic, forming nearly half of all UPS [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Ultrasound for Evaluation of a Large Undifferentiated Pleomorphic Sarcoma in the Lower Extremity of an Elderly Male

Gencarelli¹,

Hali²,

Aurup³

2022

Cureus

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Soft tissue sarcomas arise infrequently and make up less than 1% of all cancers. An undifferentiated pleomorphic sarcoma (UPS), formerly known as a malignant fibrous histiocytoma, is a malignant subtype of soft tissue sarcoma identified by a lack of specific immunohistochemical markers for lineage differentiation. These tumors are aggressive and enlarge rapidly with an increased risk of metastasis, thus prompt diagnosis, treatment, and post-resection surveillance are imperative. This case report demonstrates an incidental finding of a large undifferentiated pleomorphic sarcoma of the posterior thigh in an 86-year-old male initially evaluated with a bedside ultrasound.

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Malignant fibrous histiocytoma, now referred to as Undifferentiated Pleomorphic Sarcoma: A Case Report of an unexpected histology of a subcutaneous lesion

Abstract: Highlights Think of undifferentiated pleoimorphic sarcoma as a differential in older adults with a history of radiation therapy. It is important to discover the type and grade of the tumor. Patients should be thoroughly worked up for the best possible outcome.

Cited by 9 publications

References 11 publications

Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Primary Pulmonary Undifferentiated Pleomorphic Sarcoma: A Rare Malignant Lung Tumor

Use of Ultrasound for Evaluation of a Large Undifferentiated Pleomorphic Sarcoma in the Lower Extremity of an Elderly Male

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