Malignant fibrous histiocytoma of the mandible

Narváez, José Antonio; Muntané, Amadeo; Narváez, Javier; Martin, Ferran; Monfort, J. L.; Pons, L. C.

doi:10.1007/s002560050043

Cited by 14 publications

(7 citation statements)

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“…In our case, however, only a large solitary lesion was observed. The differential diagnosis should also include odontogenic tumors, osteosarcoma, osteochondroma, Burkitt's lymphoma, Hodgkin's disease, metastatic tumors, carcinoid tumors, malignant fibrous histiocytoma, leiomyosarcoma, and myofibroma [22][23][24][25][26][27]. Incisional biopsy is the primary approach to making a definitive diagnosis, and immunohistochemical staining can be very helpful in differentiating the nature of these tumors [28].…”

Section: Discussionmentioning

confidence: 99%

Mandibular mass as the presenting manifestation of IgM myeloma in a 22-year-old man

Ho¹,

Chen²,

Yiang³

et al. 1999

Annals of Hematology

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We report here the youngest known IgM myeloma patient to have presented with a mandibular mass. A 22-year-old Chinese man sought medical attention due to a mass over his right mandible that had been growing progressively for 6 months. A solitary osteolytic lesion in the right mandible was identified radiologically. Incisional biopsy revealed the presence of plasma cells of monoclonal origin, as evidenced by the exclusively positive staining of the kappa light chain. The diagnosis of multiple myeloma with mandibular involvement was confirmed by bone marrow examination. Further tests, including immunoglobulin electrophoresis and assay of the serum levels of kappa and lambda light chains, demonstrated that his myeloma was of the IgM, kappa subtype. The patient achieved a nonsustained partial response to six courses of melphalan and prednisolone therapy and palliative radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Mandibular mass as the presenting manifestation of IgM myeloma in a 22-year-old man

Ho¹,

Chen²,

Yiang³

et al. 1999

Annals of Hematology

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“…MFH of the mandible is very rare with only thirty documented cases, showing strong tendency for localization in the posterior portion of the mandible. Only one case involving anterior portion of the mandible and only four cases of submandibular MFH have been reported [2,8]. In view of these findings from the literature this particular case becomes distinctly unique as it occurred in the anterior part of the mandible with pathological fracture in left parasymphysis region along with involvement of the submandibular glands (Fig.…”

Section: Discussionmentioning

confidence: 92%

“…MFH of the jaws has a distinct clinical behaviour exclusive to this location, being very aggressive with a high rate of local recurrences and frequent metastases [10]. The behaviour of MFH is more aggressive than that of fibrosarcoma and osteosarcoma in this site [8]. The most frequent signs and symptoms at the time of presentation are swelling and pain.…”

Section: Discussionmentioning

confidence: 99%

Malignant Fibrous Histiocytoma: An Uncommon Sarcoma with Pathological Fracture of Mandible

Lambade¹,

Lambade

Saha³

et al. 2013

J. Maxillofac. Oral Surg.

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Malignant fibrous histiocytoma, the most frequent soft tissue sarcoma of adulthood, was first described as a new malignant tumour by O'Brian and Stout in the 1960s and the details of the histopathological features of MFH were first described by Kempson and Kyriakos. Despite the frequency of diagnosis, MFH has remained an enigma as no true cell of origin has ever been identified. Treatment consists of surgical excision and in some cases chemotherapy and radiation. Early and complete surgical removal using wide or radical resection is indicated because of the aggressive nature of the tumor. The combination of infrequent occurrence, varied pathologic features, uncertain histogenesis, numerous subtypes and the many potential sites of presentation makes these tumors a challenge for the diagnostician, surgeon and oncologist. Close follow-up after treatment is important, as local recurrence is common and early metastasis to the lungs is also frequent, which are the reasons for high mortality rate in MFH.

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“…A single case of MFH in the buccal region was also reported [Ogawa A et al, 2005]. In the literature, in cases of MFH in the head and neck, the onset age ranged from 16 years old in a patient with MFH in the mandible to 85 years old in a patient with MFH in the eyelid, and the mean age of 12 patients with head and neck MFH was reported to be 55 years old [Khong JJ et al, 2005, Barnes L et al, 1988, Narvaez JA et al, 1996. The occurrence of MFH in membranous bones is unusual.…”

Section: Malignant Fibrous Histiocytoma Of Head and Neckmentioning

confidence: 99%