Malignant Fibrous Histiocytoma of the Ileum at a Site of Previous Surgery: Report of a Case

Froehner, Michael; Gaertner, Hans-Juergen; Hakenberg, Oliver W.; Wirth, Manfred P.

doi:10.1007/s005950170177

Cited by 11 publications

(11 citation statements)

References 19 publications

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“…5 In our patient, it was impossible to distinguish the primary site of the lesion within the abdomen and there was no evidence of a primary tumor in the extremities, or elsewhere outside the peritoneal cavity. Our patient's surgical history supports the opinion of Froehner et al 13 that chronic postoperative repair processes may be a promoting factor in the tumorigenesis of this neoplasm, based on the analogy of MFH arising in different sites.…”

Section: Discussionsupporting

confidence: 86%

Malignant Fibrous Histiocytoma of the Abdominal Cavity: Report of a Case

et al. 2003

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Malignant fibrous histiocytoma (MFH) is a soft-tissue sarcoma originating from fibroblast cells, characterized by a high rate of metastasis or recurrence. This tumor rarely develops in the gastrointestinal tract, with no more than 30 cases described in the literature. We report a case of MFH of the abdominal cavity in a 45-year-old woman who presented with epigastric pain, anorexia, and weight loss. A computed tomography (CT) scan of the abdomen revealed multiple solid tumors in the peritoneal cavity. We performed exploratory laparotomy and found at least 15 solid whitish tumors attached to the wall of the small intestine, as well as to the parietal peritoneum. There were three metastases in the liver. All of the tumors were excised, most of which were about 10 cm in diameter. Histopathological findings indicated a stromal tumor consisting of spindle cells, and immunohistochemical examination of the resected specimens established the definite diagnosis of a pleomorphic MFH. The patient had an uneventful postoperative course and was given adjuvant chemotherapy. She is currently well 2 years after her operation. We review the clinical picture of this tumor in the abdominal cavity, and discuss its diagnosis, pathogenesis, and treatment.

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Section: Discussionsupporting

confidence: 86%

Malignant Fibrous Histiocytoma of the Abdominal Cavity: Report of a Case

et al. 2003

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“…One case of primary intestinal MFH attributed to a postoperative adhesive intestinal process due to previous abdominal surgery has also been documented. 24 In conclusion, although gastrointestinal tract involvement from MFH occurs most frequently in the small intestine, clinicians and pathologists must also consider the above-described tumor type, and include this type of tumor in the differential diagnosis of small intestinal lesions. Two major clinical manifestations of intestinal involvement are bleeding from ulcerated tumors and intussusception caused by polypoid tumors.…”

Section: Discussionmentioning

confidence: 98%

“…4 The chronic postoperative repair process is thus considered to possibly be a promoting factor in the tumorigenesis of this neoplasm, on the analogy of malignant fibrous histiocytoma arising at different sites. 24 In fact, several reports have described MFH associated with bone infarction or trauma, artificial implants, surgical incisions or burn scar, and chronic ulcerations. One case of primary intestinal MFH attributed to a postoperative adhesive intestinal process due to previous abdominal surgery has also been documented.…”

Section: Discussionmentioning

confidence: 99%

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Primary Malignant Fibrous Histiocytoma of the Small Intestine Presenting as an Intussusception: Report of a Case

Kotan¹,

Kosem²,

Alıcı³

et al. 2002

Surgery Today

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Malignant fibrous histiocytoma occurs most commonly in the extremities and trunk, but rarely in the visceral organs. Malignant fibrous histiocytoma of the small intestine is an extremely rare condition. To our knowledge, only ten cases of primary tumors involving the small intestine have been described up to now. Among them only one case has been reported to lead to intussusception. This case report documents the appearance of a storiform-pleomorphic type primary malignant fibrous histiocytoma of the ileum, which led to intussusception, in a 58-year-old man with a 3-month history of dyspepsia, weight loss, general fatigue, and nonspecific abdominal pain. The patient was well with no sign of disease at 8 months after surgery. The clinical and pathologic characteristics of malignant fibrous histiocytoma of the small intestine as found in the literature are also reviewed.

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“…The pathogenesis of MFH has not been clarified to date. However, it has been recognized as a complication of radiation, resulting from chronic postoperative repair, trauma, surgical incisions or burn scars [10][11][12][13] . Primar y MFH of the intestine is ver y rare.…”

Section: Discussionmentioning

confidence: 99%

Primary intestinal malignant fibrous histiocytoma: Two case reports

Fu¹

2007

WJG

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Case 1A 70-year old man was admitted for recurrent right lower quadrant abdominal pain for about 50 d. He had no recent history of fever, vomiting, diarrhea, or constipation. Physical examination revealed a slightly tender fist-size mass in the right lower quadrant of the abdomen. Laboratory examination showed a white blood cell count of 5.02 × 10 9 /L, and a neutrophil count of 68.3%. Abdominal ultrasonography revealed a large hypoechoic mass in the right lower quadrant and an abdominal computed tomography demonstrated a large soft-tissue mass in the right lumbar region and iliac fossa ( Figure 1A). Chest X-ray and computed tomography showed a mass on the hilum of the right lung ( Figure 1B). Barium enema and colonofiberscopy were not performed owing to the patient's abdominal pain. At laparotomy, a tumor was found originating from the cecum and infiltrating into the right lateral peritoneum. There was a suspicious metastatic nodule located on the surface of the right lobe of the liver. A right hemicolectomy was carried out, and reconstruction was performed by an ileotransverse endto-end anastomosis. Grossly, an ulcerative annular tumor undergone necrosis was seen in the cecum, measuring 12 cm × 10 cm. There was a tumor nodule on the mesentery, measuring 3 cm × 2 cm. On cut section, the tumor was soft in consistency, solid and grayish-white in color. Microscopic examination revealed that the tumor was pleomorphic and consisted of spindle-shaped cells, oval cells, pleomorphic giant cells, and inflammatory cells. There were involvements of two lymph nodes. Immunohistochemical stains were positive for vimentin (Figure 2), KP-1, α 1-antitrypsin AbstractMalignant fibrous histiocytoma (MFH) occurs most commonly in the extremities and trunk, but rarely in the intestine. Here we report two cases of primary intestinal MFH. The first case was a 70-year old man admitted for recurrent right lower quadrant abdominal pain. At laparotomy, a tumor was found originating from the cecum, with a suspicious metastatic nodule on the surface of the right lobe of the liver. A right h e m i c o l e c t o m y w a s p e r f o r m e d f o l l o w e d b y a n ileotransverse end-to-end anastomotic reconstruction. T h e s e c o n d c a s e w a s a 4 3 -y e a r o l d m a n w i t h intussusceptions of the small intestine. An emergent laparotomy revealed 4 pedunculated masses in the small bowel and a partial resection of the small intestine was performed. Though the symptoms were not typical, based on histological and immunohistochemical studies, the patients were diagnosed as MFH of the intestine. They were not treated with chemotherapy or radiotherapy and both died within 3 mo. MFH of the intestine is an extremely rare neoplasm with an aggressive biological behavior. The pathogenesis of this disease has not been clarified to date. Complete surgical excision is preferred, adjuvant chemotherapy or radiotherapy may be advisable.

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Malignant Fibrous Histiocytoma of the Ileum at a Site of Previous Surgery: Report of a Case

Cited by 11 publications

References 19 publications

Malignant Fibrous Histiocytoma of the Abdominal Cavity: Report of a Case

Malignant Fibrous Histiocytoma of the Abdominal Cavity: Report of a Case

Primary Malignant Fibrous Histiocytoma of the Small Intestine Presenting as an Intussusception: Report of a Case

Primary intestinal malignant fibrous histiocytoma: Two case reports

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