Malignant Fibrous Histiocytoma Proliferative Compartment and Heterogeneity of “Histiocytic” Cells

Iwasaki, Hiroshi; Yoshitake, Kenzo; Ohjimi, Yuko; Kikuchi, Masahiro; Isayama, Teruto; Yoh, Sansen; Shinohara, Norio; Enjoji, Munetomo

doi:10.1097/00000478-199208000-00001

Cited by 48 publications

(24 citation statements)

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“…Osteosarcoma is defined as a malignant tumor of mesenchymal origin with bone or osteoid formation driven by the proliferating tumor cells (15) or by normal osteoblasts induced by tumor-derived BMP. MFH is also derived from multipotential primitive mesenchymal progenitor cells (16,17), but the tumor cells are devoid of bone-forming capacity despite BMP production as reported by Yoshikawa et al (9) and confirmed in the present study. Possible explanations for the lack of bone formation in MFH despite the expression of BMP molecules may be derived from a defective molecular form of BMP produced by the tumor cells resulting in inactive BMP or defective signaling of BMP in MFH cells.…”

Section: Discussionsupporting

confidence: 89%

Expression of Bone Morphogenetic Protein and its Receptors in Osteosarcoma and Malignant Fibrous Histiocytoma

Mehdi

Shimizu

Yoshimura

et al. 2000

Japanese Journal of Clinical Oncology

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Abbreviations: BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; MFH, malignant fibrous histiocytoma Background: Bone morphogenetic protein (BMP) activity has been found in cases of malignant fibrous histiocytoma (MFH) and osteosarcoma but only tumors in the latter category show evidence of ossification. The aim of this study was to try to understand this difference by examination of the distribution of BMP and its receptors (BMPR) for this bone inducing protein in these tumors. Methods: Sections of 11 osteosarcoma and 10 MFH were analyzed immunohistochemically for BMP and BMPRs by use of the avidin-biotin peroxidase method. Results: Nine out of 11 osteosarcoma cases (80.1%) showed positive staining for both BMP and BMPRs. Two cases of chondroblastic type osteosarcoma did not show any significant staining for BMP and BMPRs. In eight out of 10 MFH cases (80%) there was positive staining for BMP. No immunoreactivity for BMPRs was found in any case of MFH. Conclusions: MFH does not express BMPRs and this may be the reason why MFH tumors do not ossify, even in the presence of BMP.

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Section: Discussionsupporting

confidence: 89%

Expression of Bone Morphogenetic Protein and its Receptors in Osteosarcoma and Malignant Fibrous Histiocytoma

Mehdi

Shimizu

Yoshimura

et al. 2000

Japanese Journal of Clinical Oncology

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“…The heterogeneity of the lesion has been a major question of its unknown histogenesis [2,12]. Immunohistochemical [5][6][7][8] or electron microscopic studies [3][4][5] have also shown the heterogeneous characters of the cells constituting the MFH lesion. Cell culture and karyotypic studies [9][10][11] have demonstrated the potential of the tumor cell to differentiate in various directions.…”

Section: Discussionmentioning

confidence: 99%

“…These studies, however, do not elucidate the proportion of the tumor cells in the heterogeneous population of cells in the MFH lesion. Immunohistochemical studies have revealed that in many MFH cases fibroblastlike, histiocytelike, and even bizarre giant cells have shown more than 70% positivity for the proliferating cell nuclear antigen [8]. The expression of the proliferating nuclear antigen implies the proliferative state of the cells, but does not essentially mean its neoplastic nature.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor consists mainly of fibroblastlike cells, histiocytelike cells, and some bizarre giant cells. Although nature and origin of these morphologically heterogeneous cells have been investigated by various methods, such as electron microscopy [3][4][5], immunohistochemistry [5][6][7][8], or cell culture studies [3,[9][10][11], the histogenesis of the disease is still debatable [2,12]. Clonality analysis of the heterogeneous cell components of MFH will give rise to the further understanding of this question.…”

Section: Introductionmentioning

confidence: 99%

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Clonal Composition of Malignant Fibrous Histiocytoma: Analysis by PCR-Based Assay of the Human Androgen Receptor Gene (HUMARA)

et al. 1998

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Malignant fibrous histiocytoma (MFH), the most common soft-tissue sarcoma, consists mainly of two different cell populations: histiocytelike and fibroblastlike cells. It has been suggested to contain a large amount of reactive histiocytes and fibroblasts hard to distinguish from the tumor cells. In this study, the clonality of MFH was determined by analyzing the patterns of X chromosome inactivation at the human androgen receptor gene (HUMARA) using DNA samples from archival snap-frozen and paraffin-embedded tissues. All the eleven informative female heterozygotes without severe inflammation showed the monoclonal pattern; 8 storiform-pleomorphic (6 distinct, 2 relative monoclonal pattern) and 3 myxoid (3 distinct monoclonal pattern) subtype. Although normal tissue DNA, amplifiable by the polymerase chain reaction, valid for the assay was not available in these cases, statistically at least 5 cases are monoclonal (p = 0.037 <0.05), even when markedly skewed lyonization were to primarily exist in the normal tissue at the highest rate as ever reported (33%). Experiments using the mixture of monoclonal and polyclonal DNA at varying ratios have suggested that a distinct monoclonal pattern is obtained only when the monoclonal component exceeds 80%. Our study demonstrates that most cells that are present in MFH are monoclonal in origin which may be the population of tumor cells.

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“…There was no evidence of osteoid formation and the giant cells appeared to be concentrated around areas of hemorrhage and necrosis, suggesting a reactive rather than a neoplastic origin. This presumption is further sup ported by the CD68 and proliferating cell nuclear antigen positivity of these cells [5,7], Differentiation of leiomyosarcoma with osteoclast-like giant cells from giant cell MFH is possible with the use of immunohistochemical markers in addition to specific his tological criteria. Fibrous histiocytomas usually stain pos itive with monoclonal antibodies for vimentin and ctp antichymotrypsin.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma with Osteoclast-Like Giant Cells of the Spermatic Cord

et al. 1996

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We describe a case of leiomyosarcoma with osteoclast-like giant cells arising form the spermatic cord and involving the testis. This is a rare tumor which is histologically similar to the giant cell variant of malignant fibrous histiocytoma. No such cases have been reported arising from the external genitalia. The patient was initially treated with local excision. He had a local recurrence 7 years later which was treated with radical excision and adjuvant radiation. The indolent nature of the tumor, with a long survival of 7 years after initial diagnosis followed subsequently by a more aggressive clinical course, is emphasized.

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Malignant Fibrous Histiocytoma Proliferative Compartment and Heterogeneity of “Histiocytic” Cells

Cited by 48 publications

References 0 publications

Expression of Bone Morphogenetic Protein and its Receptors in Osteosarcoma and Malignant Fibrous Histiocytoma

Expression of Bone Morphogenetic Protein and its Receptors in Osteosarcoma and Malignant Fibrous Histiocytoma

Clonal Composition of Malignant Fibrous Histiocytoma: Analysis by PCR-Based Assay of the Human Androgen Receptor Gene (HUMARA)

Leiomyosarcoma with Osteoclast-Like Giant Cells of the Spermatic Cord

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