Malignant fibrous xanthomas

O’Brien, Justin; Stout, Arthur Purdy

doi:10.1002/1097-0142(196411)17:11<1445::aid-cncr2820171112>3.0.co;2-g

Cited by 808 publications

(140 citation statements)

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“…The term was first introduced in 1963 to refer to a group of soft tissue tumors characterized by a storiform or cartwheel-like growth pattern, which were believed to be derived from histiocytes on the basis of early tissue culture studies demonstrating ameboid movement and phagocytosis of explanted tumor cells. 1,2 However, ultrastructural studies both endorsed and refuted the histiocytic origin of these tumors. With the advent of immunohistochemistry and the accessibility of numerous monoclonal antibodies directed against various structural proteins of specific cell types, the phenotype of this tumor was shown to be more closely aligned with a fibroblast than a histiocyte.…”

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confidence: 99%

An approach to pleomorphic sarcomas: can we subclassify, and does it matter?

Goldblum

2014

Modern Pathology

101

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The term malignant fibrous histiocytoma (MFH) has been supplanted by undifferentiated pleomorphic sarcoma (UPS). Even now, however, a number of pleomorphic neoplasms are classified as UPSs when in fact at least a subgroup of these can be more precisely classified as a pleomorphic sarcoma with a specific line of differentiation. Still others are pseudosarcomas, most commonly sarcomatoid carcinomas. This review will discuss historical aspects of MFH/UPS as well as provide an approach to the pleomorphic malignant neoplasm with a discussion of useful ancillary techniques in the evaluation of such cases.

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confidence: 99%

An approach to pleomorphic sarcomas: can we subclassify, and does it matter?

Goldblum

2014

Modern Pathology

101

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“…Since the description of malignant fibrous xanthomas in man [9] in 1964, there has been extensive reevaluation and reclassification of neoplasms of soft tissues that present a varied morphologic appearance and are believed to be of histiocytic origin. Tumors in this group are known as malignant fibrous histiocytomas.…”

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Malignant Fibrous Histiocytoma in Dogs and Cats

et al. 1979

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Abstract. Five soft tissue tumors of varied morphology in dogs and cats were classified as malignant fibrous histiocytomas on the basis of their histologic composition. All were composed of varying mixtures of histiocytes and fibroblasts and three contained large multinucleated cells. This giant cell variant of malignant fibrous histiocytoma was seen only in cats. These tumors are comparable to those described in man as malignant fibrous histiocytoma on the basis of the malignant histiocyte and its varied morphology and function.

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“…Anahtar Sözcükler: Böbrek, Malign fibröz histiyositom, Tanı, Metastaz ıNTRODUCTıON Malignant fibrous histiocytoma is the most common soft tissue sarcoma in adults (1). It has first been described by O'Brien and Stout in 1964 and originates from primitive mesenchymal cells with histiocytic and fibroblastic differentiation (2). The typical locations are the extremities (67-75%) and the retroperitoneum (6-16%) (3).…”

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confidence: 99%

Giant hyperplastic polyp in the stomach

Duman¹,

Ayhan²,

İşisağ³

et al. 2010

TJPATH

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Primary renal malignant fibrous histiocytoma is extremely rare. The prognosis is generally poor because of the high rate of local recurrence even if radical surgery is performed. We report a case of primary renal malignant fibrous histiocytoma in a 43-year-old woman. A well-defined renal mass (10x9x7cm) with lobulated contour was revealed by abdominal ultrasonography and computerized tomography in our patient who presented with left-flank pain. The contralateral kidney and renal functions were normal. No other primary tumor focus was detected by screening performed to exclude a metastasis to the kidney. However, a nodule consistent with metastasis was identified in the liver. The patient underwent left radical nephrectomy. A huge, yellowish-white, partly necrotic neoplasm infiltrating the renal parenchyma, perirenal fat and adrenal tissue was revealed by gross examination. Microscopically, the tumor was composed of pleomorphic spindle to polygonal cells arranged in fascicles and storiform structures with extensive necrosis. Twelve mitotic figures were noted in 10 high power fields. Immunohistochemical staining for vimentin and CD68 were positive whereas pan-cytokeratin, smooth muscle actin, S-100, HMB-45 and desmin were negative. "A pleomorphic type of malignant fibrous histiocytoma" was diagnosed based on both the microscopic and immunohistochemical findings. The patient presented with multiple bilateral lung metastasis three years after nephrectomy. Histopathological examination is essential since malignant fibrous histiocytoma cannot be differentiated clinically and radiologically from other lesions with kidney involvement. The overall prognosis is unfavorable with a recurrence rate of more than 50% and the 5-yearsurvival rate is only 14%.

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Malignant fibrous xanthomas

Cited by 808 publications

References 13 publications

An approach to pleomorphic sarcomas: can we subclassify, and does it matter?

An approach to pleomorphic sarcomas: can we subclassify, and does it matter?

Malignant Fibrous Histiocytoma in Dogs and Cats

Giant hyperplastic polyp in the stomach

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