Malignant giant cell tumor of tendon sheath

Castens, H P; Howell, Robert S.

doi:10.1007/bf01102878

Cited by 57 publications

(31 citation statements)

References 8 publications

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“…This bone erosion is suggested to occur because of pressure from the soft-tissue mass (6). However, invasion and destruction of the adjacent bone matrix has been observed as well (8,11). Furthermore, GC derived from GCTTS have been shown to resorb bone (12).…”

Section: Discussionmentioning

confidence: 99%

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Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Hansen

Gäumann

et al. 2001

Modern Pathology

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The expression of cysteine proteinases cathepsins B and K and of the endogenous inhibitor of cysteine proteinases, cystatin C, was investigated in tissue specimens of patients with giant cell tumor of tendon sheath (GCTTS). Expression of both enzymes was examined by immunohistochemistry in tissue specimens of 14 patients with GCTTS. Applying double-labeling techniques, the coexpression of cathepsin B and its major endogenous inhibitor cystatin C was additionally studied. Cells expressing the respective proteins were further characterized with the macrophage markers HAM56 and anti-CD68 (clone PG-M1). Cathepsin B could be detected in numerous HAM56-positive mononuclear cells (MC), but only in very few giant cells (GC). In contrast, cathepsin K was predominantly identified in GC that were also strongly immunoreactive for cystatin C and CD68. Coexpression of cathepsin B and cystatin C occurred only in a few MC. The strong expression of both cathepsin B and K suggests that in GCTTS, bone erosion might be mediated not only by pressure of the proliferative tissue, but also by matrix-degrading cysteine proteinases. Because previous studies showed that osteoclasts express high levels of CD68, cathepsin K, and cystatin C but not of cathepsin B, our study contributes to the view that GC of GCTTS and osteoclasts are closely associated.

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Section: Discussionmentioning

confidence: 99%

“…These erosions are suggested to occur because of pressure from the proliferative tissue (6). However, destruction of adjacent bone by an invasive tissue front has been observed as well (8,11). Furthermore, Athanasou et al (12) found that GC isolated from GCTTS demonstrated resorption pit formation when cultured on cortical bone slides.…”

mentioning

confidence: 99%

Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Hansen

Gäumann

et al. 2001

Modern Pathology

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“…9 However, their capacity for a certain degree of autonomous growth, local recurrence if inadequately excised and rarely metastasis speaks strongly for a neoplastic theory. 4,16,17 Although histomorphologically similar, TGCT-D, TGCT-L and PVNS differ in their clinical and biologic behavior and should not be used as synonyms. 2,8,14 TGCT-L may occur at any age but is most often seen in the third to fifth decades with a slight female predominance, unlike the younger age group, which is affected in TGCT-D and PVNS.…”

Section: Discussionmentioning

confidence: 99%

Localized Tenosynovial Giant Cell Tumor of Tendon Sheath

et al. 2000

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“…Only 37 malignant tenosynovial GCTs have been reported in the literature since 1979, and these are summarized in ►Tables 1-3. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Of these 37 patients, follow-up outcome was known in 30 patients; one patient had died of other causes (DOC). Of the remaining 29 patients, 11 patients died of disease (DOD), 4 patients were living with disease (LWD) and 14 patients had no evidence of disease (NED) since their last treatment, with a follow-up of 6 months to 49 years.…”

Section: Discussionmentioning

confidence: 99%

Malignant Giant Cell Tumor in the Carpal Tunnel: A Case Report and Review of Literature

et al. 2013

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Giant cell tumors (GCTs) of the soft tissues are, based on their site of origin, divided into nontenosynovial and tenosynovial. Nontenosynovial GCTs are less common, and their biological behavior varies from borderline malignant to full-blown malignant. Tenosynovial GCTs, also known as GCTs of the tendon sheath or pigmented villonodular synovitis are nearly always benign, with a strong capacity for local recurrence because of their pattern of growth. 1,2 We present a case of malignant tenosynovial GCT in the carpal tunnel and a review of the literature. Case ReportA 66-year-old man, with tingling and a loss of sensation in the left hand, was treated in our center for a ganglion cyst in the carpal tunnel of the left hand (►Fig. 1). This ganglion was Keywords ► malignant giant cell ► carpal tunnel syndrome AbstractBackground Malignant tenosynovial giant cell tumors (GCTs) are extremely rare, and their etiology is unknown. However, this type of malignancy is associated with high metastasis and mortality rates. Therefore, the treatment of choice is wide excision. Case Description A 66-year-old man complained of tingling and loss of sensation in the left hand, caused by a tumor that compressed the median nerve. The tumor was excised. Histopathologic examination revealed a ganglion cyst. Two years later, the patient visited our clinic with recurrent and similar complaints of the left hand. This time, however, the lesion turned out to be a malignant tenosynovial GCT and was treated by amputation of the forearm. Literature Review Since 1979, only 37 malignant tenosynovial GCTs have been reported in literature. Follow-up of these patients showed that 11 patients died of the disease, 4 patients were still living with the disease, and 14 patients had no evidence of disease after treatment. The other seven patients were lost to follow-up, and one patient died of other causes. In these 37 patients, a high incidence of lymph node metastasis (41%) and a high mortality rate (30%) were seen. Clinical Relevance Although this malignant tenosynovial GCT is very rare, high mortality rates have been observed because of the high incidence of lymph node metastases. Therefore, more awareness has to be created, to recognize and treat this tumor timely.

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Malignant giant cell tumor of tendon sheath

Cited by 57 publications

References 8 publications

Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath

Localized Tenosynovial Giant Cell Tumor of Tendon Sheath

Malignant Giant Cell Tumor in the Carpal Tunnel: A Case Report and Review of Literature

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