Malignant glomus tumor of the palm: a case report

Terada, Tadashi; Fujimoto, Jun; Shirakashi, Yusuke; Kamo, Mariko; Sugiura, Makoto

doi:10.1111/j.1600-0560.2009.01490.x

Cited by 12 publications

(15 citation statements)

References 26 publications

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“…Malignant transformation is extremely rare, but possible (10,11). Folpe et al (15) proposed the following classification criteria for malignant glomus tumors: i) Deep location and a size of >2 cm; ii) presence of atypical mitotic figures; or iii) combination of moderate to high nuclear grade and mitotic activity (5 MFs/50 HPFs).…”

Section: Discussionmentioning

confidence: 99%

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Glomus tumor of the shoulder: A case report and review of the literature

et al. 2013

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Glomus tumors are benign neoplasms that arise from neuromyoarterial glomus bodies, with clinical manifestations that include acute pain, cold intolerance and tenderness. Glomus tumors may occur anywhere in the skin, soft tissue or gastrointestinal tract, but are most frequently encountered in the nail bed of the hands. The present study reports the case of a 30-year-old female with a history of shoulder pain caused by a cystic neoformation. Following surgery, a microscopic examination revealed nests of small cells of a rounded and regular shape. The tumor cells exhibited positive expression for CD34 and smooth muscle actin. This study supports and confirms the fact that a glomus tumor is a benign neoplasm that may occur in multiple locations. Therefore, the significance of a histological and immunohistochemical approach for a correct characterization of this lesion is required.

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Section: Discussionmentioning

confidence: 99%

“…Multiple lesions have been reported in neurofibromatosis-1 (8). Malignant transformation is rarely reported (9–11). …”

Section: Introductionmentioning

confidence: 99%

Glomus tumor of the shoulder: A case report and review of the literature

et al. 2013

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“…Terada et al reported a 2.5-cm malignant glomus tumor resected from the palm, which recurred locally and was re-excised. 8 A glomus tumor of the thumb with classic symptoms was reported by Wetherington et al in a 30-year-old woman. 9 Excision revealed a tumor 0.5 cm in size that was thought to be malignant on immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…There are only 6 reports of malignant glomus tumors in the hand-ranging from 5 mm to 4.5 cm in size. 3,[5][6][7][8][9] Re-classification of glomus tumors has suggested that a diagnosis of malignant should be reserved for tumors with a risk of metastasis, which seems to correlate with a deeper location, size greater than 2 cm, atypical mitotic figures equal or greater than 5 mitotic figures per 50 high-power field, and moderate to high nuclear grade. 1 We describe the largest malignant glomus tumor of the hand ever reported.…”

Section: Introductionmentioning

confidence: 99%

Malignant Glomus Tumors of the Hand

Woodward¹

2016

Hand (New York, N,Y.)

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Background: Glomus tumors are uncommon vascular tumors of the hand. Malignant glomus tumors, now known as glomangiosarcomas, are exceedingly rare. Methods: A review of the diagnosis and treatment of malignant glomus tumors is presented along with a report of the largest malignant glomus tumor of the hand to date. Results: The review illustrates the diagnostic and management challenges of 6 previously reported glomangiosarcomas. Conclusion: The rare nature of malignant glomus tumors mandates case presentation and longitudinal analysis to help guide surgical management and optimize outcomes.

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“…Malignant GT (MGT) is very rare, and only a few cases have been reported [18][19][20][21][22][23][24][25]. The malignancy of GT is now based on the system proposed by Folpe et al in 2001 [12].…”

Section: Introductionmentioning

confidence: 99%

Malignant glomus tumor of the foot with obvious neuroendocrine differentiation: a with immunohistochemical studies

Terada¹

2014

pjp

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Obvious neuroendocrine differentiation has not been reported in glomus tumor. The author herein reports a malignant glomus tumor of the foot showing obvious neuroendocrine differentiation. A 63-year-old woman presented with tumor of the left foot. The tumor was superficially seated, and located in the dermis. It was completely resected with wide margins. It measured 0.7 × 0.7 × 0.6 cm. Microscopically, the tumor was composed of atypical epithelioid cells located around blood vessel-like structures. The epithelioid cells showed relatively clear cytoplasm and severe cellular atypia, and resembled basal cell carcinoma. Focal areas of squamoid differentiation, carcinoid patterns, and neural differentiations were seen. There was no necrosis or atypical mitosis. However, mitotic figures were seen in 16 per 50 high-power-fields (HPF). The hematoxylin and eosin (HE) diagnosis was basosquamous carcinoma. Immunohistochemically, the tumor cells were strongly positive for vimentin, α-smooth muscle actin, and neuron-specific enolase. The tumor was focally positive for NCAM, synaptophysin and chromogranin. The blood vessel-like structures had a layer of CD31-and CD34-positive endothelial cells. Tp53 was positive and the Ki-67 labeling index was 23%. The tumor cells were negative for cytokeratin (CK) AE1/3, CK CAM5.2, CK5, CK6, CK7, CK8, CK14, CK18, CK19, CK20, p63, EMA, CEA, CA19-9, desmin, myoglobin, HMB-45, Melan-A, S100 protein, MUC1, MUC2, MUC5AC, and MUC6. Taken together with HE histology, the tumor was labeled as malignant glomus tumor with neuronal differentiation, based on the classification system of Folpe et al. The post-pathological diagnosis whole body examination using CT, MRI, PET, and endoscopies identified no tumors. The patient is now free from tumor and healthy 18 months after the resection.

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Malignant glomus tumor of the palm: a case report

Cited by 12 publications

References 26 publications

Glomus tumor of the shoulder: A case report and review of the literature

Glomus tumor of the shoulder: A case report and review of the literature

Malignant Glomus Tumors of the Hand

Malignant glomus tumor of the foot with obvious neuroendocrine differentiation: a with immunohistochemical studies

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