2010
DOI: 10.4103/0019-5154.74573
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Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: A casual association?

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Cited by 7 publications
(9 citation statements)
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“…The eosinophilic granular cytoplasm is acidophilic, periodic acid–Schiff (PAS) positive and diastase-resistant [10]. Ultrastructural analysis demonstrates that the cytoplasmatic granules are an accumulation of lysosomes similar to those found in Schwann cells [2, 5, 8, 9]. Immunohistochemical diagnosis is made by the S100, NSE, Vimentin and lysosomal marker CD68 positivity that GCT demonstrates in its nucleus and cytoplasm, in line with GCT’s proposed Schwann cell origin [4, 5, 7].…”
Section: Discussionmentioning
confidence: 99%
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“…The eosinophilic granular cytoplasm is acidophilic, periodic acid–Schiff (PAS) positive and diastase-resistant [10]. Ultrastructural analysis demonstrates that the cytoplasmatic granules are an accumulation of lysosomes similar to those found in Schwann cells [2, 5, 8, 9]. Immunohistochemical diagnosis is made by the S100, NSE, Vimentin and lysosomal marker CD68 positivity that GCT demonstrates in its nucleus and cytoplasm, in line with GCT’s proposed Schwann cell origin [4, 5, 7].…”
Section: Discussionmentioning
confidence: 99%
“…Ultrastructural analysis demonstrates that the cytoplasmatic granules are an accumulation of lysosomes similar to those found in Schwann cells [2, 5, 8, 9]. Immunohistochemical diagnosis is made by the S100, NSE, Vimentin and lysosomal marker CD68 positivity that GCT demonstrates in its nucleus and cytoplasm, in line with GCT’s proposed Schwann cell origin [4, 5, 7]. Wan et al proposed that malignancy can be determined by a p53 greater than 50% and a Ki67 index greater than 10% [3].…”
Section: Discussionmentioning
confidence: 99%
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“…The most common clinical presentation is the presence of an asymptomatic mass found incidentally during the evaluation of perianal disorders such as hemorrhoids and fissures [ 6 ]. Patients may present with anal pain, discomfort, and bleeding [ 57 , 58 ]. The tumor can also be found as a polypoid mass in the anus [ 59 ].…”
Section: Gastrointestinal Gcts By Locationmentioning
confidence: 99%