Malignant Hepatic Tumors: Short-term Reproducibility of Apparent Diffusion Coefficients with Breath-hold and Respiratory-triggered Diffusion-weighted MR Imaging

Kim, So Yeon; Lee, Seung Soo; Byun, Jae Ho; Park, Seong Ho; Kim, Jeong Kon; Park, Bumwoo; Kim, Namkug; Lee, Moon-Gyu

doi:10.1148/radiol.10091706

Cited by 136 publications

(117 citation statements)

References 26 publications

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“…30,31 Finally, the partial volume averaging effect with the surrounding liver, especially in the case of the very small ROIs in our study, may also have impaired the reliability of the ADC measurements. 32 In this regard, an international consensus preconized a minimum 2-cm ROI diameter in order to avoid inaccuracies in ADC measurements. 33 This might explain the results from Nishie et al 16 who found a significant difference between low-and high-grade HCCs with large-sized lesions [3.6 6 3.1 cm (range, 1-17 cm)].…”

Section: Discussionmentioning

confidence: 99%

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T₂and diffusion-weighted imaging

Moigne

Boussel²,

Haquin³

et al. 2014

BJR

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Objective: To evaluate the capacity of diffusion-weighted imaging (DWI) to determine the histological grade of small-sized hepatocellular carcinomas (HCCs) in liver cirrhosis in comparison with T 2 weighted imaging. Methods: 51 cirrhotic patients with 63 histologically proven HCCs #2 cm underwent abdominal MRI, including DWI (b-values 50, 400 and 800 s mm 22 ) and T 2 weighted sequences. HCCs were classified into well-differentiated HCCs (n 5 37) and moderately differentiated HCCs (n 5 26). Relative contrast ratios (RCRs) between the lesions and the surrounding liver were performed and compared between the two groups for T 2 weighted images, each b-value and apparent diffusion coefficients (ADCs). A receiver operating characteristic (ROC) analysis was performed to compare RCRs in T 2 and diffusion-weighted images.Results: We found significant differences in RCRs between well-differentiated vs moderately differentiated HCCs for b 5 50, 400 and 800 s mm 22 and T 2 weighted

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Section: Discussionmentioning

confidence: 99%

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T₂and diffusion-weighted imaging

Moigne

Boussel²,

Haquin³

et al. 2014

BJR

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“…20 Continuous variables were presented as mean Ϯ SD. Quantitative changes in each parameter were compared by using an unpaired t test between subgroups.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Skull Plain Films in Follow-up Evaluation of Cerebral Aneurysms Treated with Detachable Coils: Quantitative Assessment of Coil Mass

Ahn

Kim²,

Jung

et al. 2014

AJNR Am J Neuroradiol

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“…Reproducibility measurements of DW-MRI data are necessary to understand the magnitude of variation that can be detected confidently. Both the size and the position of lesions are known to influence reproducibility, with larger lesions being more reproducible [129] . At the time of authoring Kim et al [29] , [119] , Table 9 Estimates of apparent diffusion coefficient values of cancer vs normal tissue/benign disease reported in selected studies on different anatomical regions using a mono-exponential fit Some studies were carried out with more b-values than specified in the following table to compute intravoxel incoherent motion-specific parameters.…”

Section: Reproducibility Of Adc Valuesmentioning

confidence: 99%

Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients,in-vitroandin-vivoreproducibility

Jafar

Parsaï

Miquel

2016

WJR

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There is considerable disparity in the published apparent diffusion coefficient (ADC) values across different anatomies. Institutions are increasingly assessing repeatability and reproducibility of the derived ADC to determine its variation, which could potentially be used as an indicator in determining tumour aggressiveness or assessing tumour response. In this manuscript, a review of selected articles published to date in healthy extracranial body diffusion-weighted magnetic resonance imaging is presented, detailing reported ADC values and discussing their variation across different studies. In total 115 studies were selected including 28 for liver parenchyma, 15 for kidney (renal parenchyma), 14 for spleen, 13 for pancreatic body, 6 for gallbladder, 13 for prostate, 13 for uterus (endometrium, myometrium, cervix) In addition, six phantom studies and thirteen in vivo studies were summarized to compare repeatability and reproducibility of the measured ADC. All selected phantom studies demonstrated lower intra-scanner and inter-scanner variation compared to in vivo studies. Based on the findings of this manuscript, it is recommended that protocols need to be optimised for the body part studied and that system-induced variability must be established using a standardized phantom in any clinical study. Reproducibility of the measured ADC must also be assessed in a volunteer population, as variations are far more significant in vivo compared with phantom studies. Core tip: Diffusion-weighted magnetic resonance imaging was highlighted as a potential cancer imaging biomarker by a team of experts in a report published in 2009. We review the variability of published diffusion values in the major extra-cranial organs and focus on the validation literature, both in vivo and in vitro . A total of 115 studies were selected including for liver parenchyma, kidney, pancreatic body, spleen, gallbladder, prostate, uterus (endometrium, myometrium, cervix) and breast. We also look in detail at the published repeatability and reproducibility studies, both in vivo and in phantoms. A series of recommendations based on our findings are given at the end of this review.Jafar MM, Parsai A, Miquel ME. Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients, in vitro and in vivo reproducibility.

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Malignant Hepatic Tumors: Short-term Reproducibility of Apparent Diffusion Coefficients with Breath-hold and Respiratory-triggered Diffusion-weighted MR Imaging

Abstract: Changes in ADCs of less than approximately 30% fall into the range of measurement error. Imaging technique significantly affected ADCs of malignant hepatic tumors. Lesion location and size are potentially influential on the reproducibility of ADC measurement.

Cited by 136 publications

References 26 publications

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T₂and diffusion-weighted imaging

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T₂and diffusion-weighted imaging

Efficacy of Skull Plain Films in Follow-up Evaluation of Cerebral Aneurysms Treated with Detachable Coils: Quantitative Assessment of Coil Mass

Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients,in-vitroandin-vivoreproducibility

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Malignant Hepatic Tumors: Short-term Reproducibility of Apparent Diffusion Coefficients with Breath-hold and Respiratory-triggered Diffusion-weighted MR Imaging

Abstract: Changes in ADCs of less than approximately 30% fall into the range of measurement error. Imaging technique significantly affected ADCs of malignant hepatic tumors. Lesion location and size are potentially influential on the reproducibility of ADC measurement.

Cited by 136 publications

References 26 publications

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T2and diffusion-weighted imaging

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T2and diffusion-weighted imaging

Efficacy of Skull Plain Films in Follow-up Evaluation of Cerebral Aneurysms Treated with Detachable Coils: Quantitative Assessment of Coil Mass

Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients,in-vitroandin-vivoreproducibility

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Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T₂and diffusion-weighted imaging

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T₂and diffusion-weighted imaging