Malignant Histiocytic Disorders in Children

Malignant Histiocytosis in 3 Cats

“…Recently, it has been proposed that the origin of the malignant cells be confirmed by immunohistochemistry. [13][14][15] In humans, the use of additional staining techniques has shown that many patients originally diagnosed with MH had other diseases. 15 Special staining processes have been used both in veterinary and human medicine to try to more accurately identify MH.…”

“…15 Special staining processes have been used both in veterinary and human medicine to try to more accurately identify MH. [1][2][3][4][11][12][13][14][15] Lysozyme and alpha-1-antitrypsin, when positive, identify cells as histiocytic, ruling out a lymphoid or epithelial cell line. Cytologic characteristics of malignancy are used to differentiate malignant from benign histiocytic disease.…”

“…1,2 Chemotherapy has not been consistently successful in treatment of this disease in any species. 1,[4][5][6]9,10,13,14,18 Either doxorubicin or a vincristine, cyclophosphamide, and prednisone protocol have been used in humans and dogs with improvement in survival, but without remission of the disease. 13,18 A response rate of 57%, with a median duration of 38 months, was seen in one study in humans, when a combination of either cyclophosphamide, doxorubicin, vincristine, and prednisone or chloromethine, vincristine, procarbazine, and prednisone were used.…”