Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark

Nielsen, Lise Nikolic; Andreasen, Simon; Andersen, Sandra; Kristensen, Annemarie T.

doi:10.1136/vr.b4756

Cited by 14 publications

(17 citation statements)

References 27 publications

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“…Certain breeds are at greater risk for the development of HS, including the Bernese mountain dog, Golden retriever, Labrador retriever, Flat coated retriever and Rottweiler. [13][14][15][16][17] Despite its frequent occurrence in other organ systems, CNS HS has been rarely reported in Bernese mountain dogs and Rottweilers. 3,12,18 Conversely, although not considered an at-risk breed for HS in other body regions, the Pembroke Welsh Corgi comprised 7/15 (47%) cases of CNS HS in a previous report.…”

Section: Discussionmentioning

confidence: 99%

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Mariani

Jennings

Olby

et al. 2015

Veterinary Internal Medicne

100

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BackgroundReports of histiocytic sarcoma (HS) involving the central nervous system (CNS) are sparse and consist mainly of case reports describing 1–3 animals.ObjectiveThe objective of this study was to report the signalments, clinical signs, clinicopathologic and diagnostic imaging findings, treatment, and outcome of a series of dogs with HS and CNS involvement.AnimalsNineteen dogs with HS examined at veterinary referral hospitals.MethodsRetrospective case series. Medical records were reviewed and cases with a histopathological diagnosis of CNS HS were included in the study. Diagnostic imaging studies of the CNS were evaluated and histopathologic samples were reviewed to confirm the diagnosis.ResultsRetrievers and Pembroke Welsh Corgis were overrepresented in this cohort of dogs. Tumors involved the brain in 14 dogs and the spinal cord in 5. In 4 dogs, HS was part of a disseminated, multiorgan process whereas it appeared confined to the CNS in 15 dogs. Diagnostic imaging had variable appearances although extraaxial masses predominated in the brain. There was meningeal enhancement in all dogs that was often profound and remote from the primary mass lesion. Pleocytosis was present in all dogs with CSF evaluation. Median survival was 3 days.Conclusions and Clinical ImportanceBreed predispositions appear to vary from reports of HS in other organ systems. Some unique imaging and clinicopathologic characteristics, particularly brain herniation, profound meningeal enhancement, and pleocytosis in combination with 1 or more mass lesions, might help to differentiate this neoplasm from others involving the CNS, although this requires further study.

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Section: Discussionmentioning

confidence: 99%

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Mariani

Jennings

Olby

et al. 2015

Veterinary Internal Medicne

100

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“…A recent study of Danish Bernese mountain dogs described 13 dogs diagnosed with malignant histiocytosis, of which 11 were genealogically related [76]. In 1995 Padgett analysed the inheritance of “histiocytosis” in 127 affected Bernese mountain dogs and suggested a polygenic mode of inheritance and a calculated heritability of 0.298 [57].…”

Section: Histiocytic Sarcomamentioning

confidence: 99%

Breed-Predispositions to Cancer in Pedigree Dogs

Dobson

2013

ISRN Veterinary Science

260

278

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Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs may be affected, it is notable that some breeds of pedigree dogs appear to be at increased risk of certain types of cancer suggesting underlying genetic predisposition to cancer susceptibility. Although the aetiology of most cancers is likely to be multifactorial, the limited genetic diversity seen in purebred dogs facilitates genetic linkage or association studies on relatively small populations as compared to humans, and by using newly developed resources, genome-wide association studies in dog breeds are proving to be a powerful tool for unravelling complex disorders. This paper will review the literature on canine breed susceptibility to histiocytic sarcoma, osteosarcoma, haemangiosarcoma, mast cell tumours, lymphoma, melanoma, and mammary tumours including the recent advances in knowledge through molecular genetic, cytogenetic, and genome wide association studies.

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“…Indeed, the BMD was the most short-lived breed in 1 study, with a mean life expectancy of 6.8 years [ 5 ]. More recent studies reported mean and median life expectancies of 7.1 and 7.0–8.0 years, respectively, compared with a calculated mean and median expectancy for all breeds of 10 and 11 years, respectively [ 1 , 4 , 6 , 7 ]. Although larger breeds have been shown to have a lower average age at death than smaller breeds [ 1 , 6 , 8 – 10 ], the life expectancy of BMDs remains low when compared with breeds of similar size, such as flat coated retrievers (mean, 9.5 years) or German shepherd dogs (mean, 10.3 years) [ 1 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Life expectancy and causes of death in Bernese mountain dogs in Switzerland

et al. 2016

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BackgroundNew regulations by the Swiss Federal Food Safety and Veterinary Office provide for the monitoring of breed health by Swiss breeding clubs. In collaboration with the Swiss Bernese Mountain Dog Club, the purpose of this study was to investigate the causes of death in purebred dogs registered by the club and born in 2001 and 2002.ResultsOf a total of 1290 Bernese mountain dogs (BMDs) born in 2001 and 2002 in Switzerland, data was collected from owners and veterinarians using a questionnaire designed for this study from 389 dogs (30.2 %). By the end of the study, 381/389 dogs (97.9 %) had died. The median life expectancy of all dogs was 8.4 years (IQR, 6.9–9.7). Female dogs had a significantly longer median survival (8.8 years; IQR, 7.1–10.3) than male dogs (7.7 years; IQR, 6.6–9.3) (P < 0.00). The cause of death was unknown in 89/381 dogs (23.4 %). For the remaining dogs, the most frequent causes of death were neoplasia (222/381, 58.3 %), degenerative joint disease (16/381, 4.2 %), spinal disorders (13/381, 3.4 %), renal injury (12/381, 3.1 %), and gastric or mesenteric volvulus (7/381, 1.8 %). However, large numbers of dogs were diagnosed with neoplasia without histopathologic or cytologic confirmation. Dogs with neoplasms had a shorter median survival than dogs with other disorders. The shortest median survival (6.8 years) was found for dogs with renal injury.ConclusionsFindings of this study confirm a high prevalence of neoplasia and associated low life expectancy in BMDs. The results underline a need for more widespread precise diagnostics and further research on malignant tumours in this breed to improve overall breed health.

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Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark

Cited by 14 publications

References 27 publications

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006–2012)

Breed-Predispositions to Cancer in Pedigree Dogs

Life expectancy and causes of death in Bernese mountain dogs in Switzerland

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