2015
DOI: 10.4236/ojmip.2015.52003
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Malignant Hyperthermia: Evaluation of “<i>Organon</i>” 9426 in Malignant Hyperthermia Susceptible Pigs

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Cited by 2 publications
(3 citation statements)
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“…This observation is consistent with actual susceptibility to the MH-PSS syndrome whenever pigs are stressed by hauling to market. The Organon 9426 data indicated a reduction in the actual number of functional sodium channels in MHS versus normal pigs [2] . Thus, aging makes the pigs more susceptible to develop the MH-PSS syndrome.…”
Section: Methodsmentioning
confidence: 98%
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“…This observation is consistent with actual susceptibility to the MH-PSS syndrome whenever pigs are stressed by hauling to market. The Organon 9426 data indicated a reduction in the actual number of functional sodium channels in MHS versus normal pigs [2] . Thus, aging makes the pigs more susceptible to develop the MH-PSS syndrome.…”
Section: Methodsmentioning
confidence: 98%
“…It is believed that this increased voltage for a longer duration is the manifestation of genetically defective sodium channels. A 30 % decrease in the actual number of sodium channels may be the result of a biological correction to enable the animal to survive with the MH syndrome genetic defect [2] .…”
Section: Methodsmentioning
confidence: 99%
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