Malignant hyperthermia

Britt, Beverley A.

doi:10.1007/bf03011418

Cited by 87 publications

(32 citation statements)

References 21 publications

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“…The consequences of these detecting stress susceptibility (Essen and Lindholm 1980) (Tarrant et al 1985). The same observations have been recorded in MH reactions induced by halothane and suxamethonium administration (Britt 1985 Fig. 3a.…”

supporting

confidence: 84%

The use of in vivo magnetic resonance imaging and spectroscopy to study porcine stress syndrome in young, halothane-susceptible pigs: Preliminary results

Janzen¹,

Stewart²,

Towner³

et al. 1994

Can. J. Anim. Sci.

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supporting

confidence: 84%

The use of in vivo magnetic resonance imaging and spectroscopy to study porcine stress syndrome in young, halothane-susceptible pigs: Preliminary results

Janzen¹,

Stewart²,

Towner³

et al. 1994

Can. J. Anim. Sci.

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“…8 Later that decade, Beverly Britt, MD, conducted pioneering research on the occurrence and manifestations of MH. 9 This seminal work demonstrated that MH was precipitated by exposure to potent inhalational anesthetics and the paralyzing agent succinylcholine but not to other anesthetics. The MH syndrome was determined to be inherited in an autosomaldominant manner and was independent of ethnicity.…”

Section: Definition Of Malignant Hyperthermiamentioning

confidence: 99%

“…17 Through the 1970s, MH mortality was close to 80%. 9 When anesthesiologists were made aware of the signs of MH and the steps required to treat it, mortality rates declined. 18 However, a specific antidote, dantrolene sodium, was not approved by the Federal Drug Administration until 1979.…”

Section: Definition Of Malignant Hyperthermiamentioning

confidence: 99%

Round Table on Malignant Hyperthermia in Physically Active Populations: Meeting Proceedings

Hosokawa

Casa

Rosenberg

et al. 2017

Journal of Athletic Training

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Context: Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking.Objective: To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research. Setting: An interassociation task force was formed by experts in athletic training, exercise science, anesthesiology, and emergency medicine. The ''Round Table on Malignant Hyperthermia in Physically Active Populations'' was convened at the University of Connecticut, Storrs, September 17-18, 2015.Conclusions: Clinicians should consider an MH-like syndrome when a diagnosis of EHS or ER cannot be fully explained by clinical signs and symptoms presented by a patient or when recurrent episodes of EHS or ER (or both) are unexplained. Further research is required to elucidate the genetic and pathophysiological links among MH, EHS, and ER.

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“…Although MH syndrome has been associated with congenital myopathies [2,9] such as Duchenne muscular dystrophy, myotonia congenita and central core disease, frequently no signs of myopathy are apparent in patients susceptible to MH [2], In the majority of cases, the mode of inheritance is clearly a single, autosomal dominant gene [5], In other families there appears to be a multigenic, reduced penetrance pattern of inheritance [10]. In addition, the MH trait does not exhibit uniform severity, but rather the MH reaction is a spectrum ranging from mild to severe (variable expressivity).…”

Section: Discussionmentioning

confidence: 99%

“…This value was defined as the caffeinespecific concentration (CSC) for the strips exposed to caffeine only, and caffeine-specific concentration-halothane (CSC-H) for strips exposed to caffeine plus halothane. In our laboratory, the diagnosis of MH susceptibility is made when the CSC value is less than 4.0 mmol/1 caffeine and the CSC-H value is less than 1.0 mmol/1 caffeine [5]. In this study, MH-susceptible muscle was termed caf feine/halothane contracture test-positive.…”

Section: Methodsmentioning

confidence: 99%

Prospective Management of Malignant Hyperthermia in the General Surgery Patient

et al. 1990

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Malignant hyperthermia (MH) is a seemingly rare genetic myopathy. Hypermetabolic crisis accompanied by a rise in body temperature to as high as 44 °C is its hallmark. MH is usually triggered by potent inhaled anesthetics and/or depolarizing muscle relaxants. Because of the extraordinary risk of death in patients who are susceptible, general surgeons may be reluctant to operate on these patients. Five such patients were referred to the General Surgery Service and the UCLA Malignant Hyperthermia Center following general surgical procedures aborted for first episodes of MH (4) or for strong family history of MH (1). They were anesthetized with nitrous oxide, barbiturates, opiates, tranquilizers and nondepolarizing muscle relaxants. The patients were not treated pro-phylactically with dantrolene. Cardiac monitoring, end-tidal pCO₂ and rectal temperatures were followed. After completion of their general surgical procedures, 4 patients had a vastus lateralis muscle biopsy and 1 patient had an external oblique muscle biopsy, with subsequent caffeine/halothane contracture studies completed. The contracture study was positive in all 5 patients. No anesthetic or surgical complications were encountered. This study demonstrates that, using our protocol, patients at risk of developing MH crisis can have general surgical procedures performed safely while undergoing appropriately selected general anesthesia.

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Malignant hyperthermia

Abstract: Malignant hyperthermia (MH) is a pharmacogenetic disorder characterized by acute hypercatabolic reactions in muscles in response to the triggering effects of certain drugs (used mainly during anaesthesia ~ and stresses.

Cited by 87 publications

References 21 publications

The use of in vivo magnetic resonance imaging and spectroscopy to study porcine stress syndrome in young, halothane-susceptible pigs: Preliminary results

The use of in vivo magnetic resonance imaging and spectroscopy to study porcine stress syndrome in young, halothane-susceptible pigs: Preliminary results

Round Table on Malignant Hyperthermia in Physically Active Populations: Meeting Proceedings

Prospective Management of Malignant Hyperthermia in the General Surgery Patient

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