Malignant Hyperthermia

Lerman, Jerrold; Parness, Jerome

doi:10.1016/b978-0-323-42974-0.00041-0

Cited by 3 publications

(2 citation statements)

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“…36,37 Hence, this work examines the effects of laser-induced heating of magnetite-reinforced PDMS nanocomposites for hyperthermia (41-44 C). 26,[38][39][40][41] The PDMS nanocomposites (NCs) were molded and the effects of MNP content on the photothermal properties of the NCs under in vitro conditions were then investigated. First, the laser-induced heating effects of the various nanocomposites are explored in deionized water and cell culture growth media.…”

Section: Introductionmentioning

confidence: 99%

“…These are in addition to its corrosion resistance and flexible properties 36,37 . Hence, this work examines the effects of laser‐induced heating of magnetite‐reinforced PDMS nanocomposites for hyperthermia (41–44°C) 26,38–41 . The PDMS nanocomposites (NCs) were molded and the effects of MNP content on the photothermal properties of the NCs under in vitro conditions were then investigated.…”

Section: Introductionmentioning

confidence: 99%

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Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

et al. 2022

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This paper presents the results of an experimental and computational study of the effects of laser‐induced heating provided by magnetite nanocomposite structures that are being developed for the localized hyperthermic treatment of triple‐negative breast cancer. Magnetite nanoparticle‐reinforced polydimethylsiloxane (PDMS) nanocomposites were fabricated with weight percentages of 1%, 5%, and 10% magnetite nanoparticles. The nanocomposites were exposed to incident Near Infrared (NIR) laser beams with well‐controlled powers. The laser‐induced heating is explored in: (i) heating liquid media (deionized water and cell growth media [Leibovitz L15+]) to characterize the photothermal properties of the nanocomposites, (ii) in vitro experiments that explore the effects of localized heating on triple‐negative breast cancer cells, and (iii) experiments in which the laser beams penetrate through chicken tissue to heat up nanocomposite samples embedded at different depths beneath the chicken skin. The resulting plasmonic laser‐induced heating is explained using composite theories and heat transport models. The results show that the laser/nanocomposite interactions decrease the viability of triple‐negative breast cancer cells (MDA‐MB‐231) at temperatures in the hyperthermia domain between 41 and 44°C. Laser irradiation did not cause any observed physical damage to the chicken tissue. The potential in vivo performance of the PDMS nanocomposites was also investigated using computational finite element models of the effects of laser/magnetite nanocomposite interactions on the temperatures and thermal doses experienced by tissues that surround the nanocomposite devices. The implications of the results are then discussed for the development of implantable nanocomposite devices for localized treatment of triple‐negative breast cancer tissue via hyperthermia.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

et al. 2022

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Anesthesia and Ancillary Drugs and the Neonate

Anderson

Lerman

2023

Neonatal Anesthesia

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Malignant Hyperthermia and Ryanodine Receptor Type 1 Gene (RyR1) Mutation in a Family in Singapore

Lai²,

Lee³

et al. 2017

Ann Acad Med Singap

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Introduction: Sporadic clinical episodes of malignant hyperthermia (MH) that develop during general anaesthesia (GA) have been reported in Singapore. However, there is no published local report of a confirmed case of MH susceptibility (MHS) by skeletal muscle contracture tests and/or molecular tests. Materials and Methods: We report 2 patients from an extended family who developed signs of clinical MH while under GA. The MH episodes were successfully treated with intravenous dantrolene sodium. Sequence analysis of the entire Ryanodine Receptor Type 1 (RyR1) coding gene was carried out in an index patient. Results: The index patient was found to carry a c.7373G>A (p.Arg2458His) mutation in exon 46. This particular mutation satisfies the criteria for a MHS causative mutation. Hence, the index patient was considered to be MHS and did not need to undergo further muscle contracture testing. The same mutation was also found in 3 other members of his extended family. Conclusion: This is the first report of a Singaporean family with at least 4 members carrying a MH-causative mutation in RyR1 gene. This report serves to highlight the existence of the putative gene for MH in Singapore, and the need for clinical vigilance during anaesthesia involving the use of triggering agents. Key words: Dantrolene, Inhalational agent, Suxamethonium

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Malignant Hyperthermia

Cited by 3 publications

References 230 publications

Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

Anesthesia and Ancillary Drugs and the Neonate

Malignant Hyperthermia and Ryanodine Receptor Type 1 Gene (RyR1) Mutation in a Family in Singapore

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