Malignant intertrigo: A subset of toxic erythema of chemotherapy requiring recognition

Smith, Sabrina M.; Milam, Philip; Fabbro, Stephanie K.; Gru, Alejandro A.; Kaffenberger, Benjamin H.

doi:10.1016/j.jdcr.2016.08.016

Cited by 18 publications

(24 citation statements)

References 8 publications

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“…The term 'malignant intertrigo' has been proposed to describe TEC affecting the intertriginous areas [3].…”

Section: Discussionmentioning

confidence: 99%

Regorafenib Induced Toxic Erythema of Chemotherapy Presenting as Malignant Intertigo with Hand Foot Skin Reaction

S¹

2017

CDOAJ

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Newer chemotherapeutic drugs often present with adverse reactions involving the skin. These reactions may be mistaken for infections, drug allergies or GVHD. Regorafenib is a multikinase inhibitor with a characteristic adverse event profile affecting the hands and feet as well as flexures. Because of a very high incidence of these reactions, adequate precautions to prevent, as well as early diagnosis and management, improve quality of life as well as outcomes of treatment.

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“…The term 'malignant intertrigo' has been proposed to describe TEC affecting the intertriginous areas [3].…”

Section: Discussionmentioning

confidence: 99%

Regorafenib Induced Toxic Erythema of Chemotherapy Presenting as Malignant Intertigo with Hand Foot Skin Reaction

S¹

2017

CDOAJ

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“…Malignant intertrigo often presents with erythematous patches with scales, crusts and erosions over intertriginous regions that usually develops two days to three weeks after the administration of chemotherapeutic agents. 1 Its pathophysiology is presumed to be caused by local accumulation of cytotoxic chemicals. At present, cytarabine and pegylated liposomal doxorubicin are the most frequently reported causative agents.…”

mentioning

confidence: 99%

“…At present, cytarabine and pegylated liposomal doxorubicin are the most frequently reported causative agents. 1,2 This condition is usually a selflimiting eruption; however, recurrence with readministration of the offending agent is not uncommon. 1,2 Usually, malignant intertrigo is not reported, and the incidence may be higher than expected.…”

mentioning

confidence: 99%

“…Diagnosis is based mainly on typical clinical presentation. 1,2 Negative results for bacterial and fungal cultures, and no satellite lesions at the periphery distinguish malignant intertrigo from infectious intertrigo. Intertriginous distribution discriminates malignant intertrigo from other chemotherapy-related skin eruptions.…”

mentioning

confidence: 99%

“…Early recognition of this entity, and management with topical or oral cortico-steroids and general topical measures can provide palliation of symptoms, and prevent unnecessary and potentially harmful treatments. 1,3…”

mentioning

confidence: 99%

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Malignant intertrigo

Liu

2018

CMAJ

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Clinical images are chosen because they are particularly intriguing, classic or dramatic. Submissions of clear, appropriately labelled highresolution images must be accompanied by a figure caption. A brief explanation (300 words maximum) of the educational importance of the images with minimal references is required. The patient's written consent for publication must be obtained before submission.

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