Malignant lymphoma in the <scp>HIV</scp>‐positive patient

Meister, Anne C.; Hentrich, Marcus; Wyen, Christoph; Hübel, Kai

doi:10.1111/ejh.13082

Cited by 36 publications

(39 citation statements)

References 82 publications

(152 reference statements)

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“…Over the decades, people living with HIV/AIDS is increasing in Yunnan, and it is still one of the provinces with highest number of HIV-infected patients in China [18]. DLBCL is the most common pathological subtype of NHL in both the general population and people living with HIV/AIDS [1][2][3]19]. A large database study shows that HIV infection continues to be an independent risk factor for death among patients with lymphoma [20].…”

Section: Discussionmentioning

confidence: 99%

“…Human immunodeficiency virus (HIV) infection is associated with an increased incidence of malignancy. HIV-associated diffuse large B cell lymphoma (DLBCL) and Burkitt's lymphoma (BL) are among the commonest cancers in HIV-positive patients [1][2][3]. Other non-Hodgkin's lymphomas (NHLs), including primary effusion lymphoma (PEL), plasmablastic lymphoma, KSHV-associated multicentric Castleman's disease, primary central nervous system (CNS) lymphoma and classic Hodgkin's lymphoma (cHL), are diagnosed in patients with HIV as well [1].…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and outcomes for HIV-associated Diffuse Large B-cell Lymphoma in China: A retrospective single-center study

Miao

et al. 2019

Preprint

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Background: Human immunodeficiency virus (HIV) infection is associated with an increased risk of aggressive lymphoma, especially diffuse B cell lymphoma (DLBCL). We aimed to analyze characteristics and outcomes of DLBCL in HIV-associated patients. Methods: We retrospectively studied HIV-infected patients with DLBCL since 2011. Data on HIV infection and lymphoma characteristics, treatment and outcome were retrieved and analyzed. Results: In 53 patients with HIV-associated DLBCL, most patients had frequent bad performance status (PS) (74%), elevated LDH level (94%), B symptoms (69%), advanced Ann Arbor (75%), bulky tumor (72%) and extra-nodal involvement (68%) at diagnosis. The median CD4 T cell count was 175/μl, and 17 patients were already on cART treatment. Plasma EBV DNA was detectable in 18 patients (53%, 18/34). Of the patients evaluated at the end of treatment, 21 (64%) achieved CR, 1 (3%) achieved PR and 6 (18%) experienced progressive disease. The 2-year progression free survival (PFS) was 50% and overall survival (OS) rate was 60%. Factors associated with poor PFS in univariate analysis were unfavorable PS, high IPI score and detectable plasma EBV load. High IPI and detectable EBV load correlated with worse OS. However, only detectable plasma EBV load was the independent factor of poor prognosis for PFS (HR: 14.46, 95% CI [2.57-81.50]) and OS (HR: 7.47, 95% CI [1.48-37.59]) in a multivariate Cox regression model. Conclusions: In our population, HIV-associated DLBCL still presented aggressive characteristics and poor survival outcomes. Plasma EBV DNA could be used as a prognostic factor in HIV-infected DLBCL.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and outcomes for HIV-associated Diffuse Large B-cell Lymphoma in China: A retrospective single-center study

Miao

et al. 2019

Preprint

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“…Its diagnosis depends on clinical suspicion and its confirmed by immunohistopathological [1]. There has been found association between this affection and infection by human immunodeficiency virus [2]. The clinical case presented is of a 48 year old, male patient with NK/T lymphoma of nasal-type and HIV infection.…”

mentioning

confidence: 94%

NK/T Lymphoma of Nasal-Type in a Patient with an HIV Infection

Cobos-Quevedo¹,

Cynthia²,

Paulina³

et al. 2018

BJSTR

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NK/T lymphoma of nasal-type is a rare affection associated with a bad prognosis, it was described in 1933 as a malignant midfacial granuloma. Its diagnosis depends on clinical suspicion and its confirmed by immunohistopathological [1]. There has been found association between this affection and infection by human immunodeficiency virus [2]. The clinical case presented is of a 48 year old, male patient with NK/T lymphoma of nasal-type and HIV infection.

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“…These factors can influence the therapeutic outcome and prognosis of patients. 4 However, to the best of our knowledge, there is currently no report of a GCF complicated with primary high-grade B-cell gastric lymphoma in an acquired immunodeficiency syndrome (AIDS) patient.…”

Section: Introductionmentioning

confidence: 99%

A gastro-colic fistula secondary to high-grade B-cell gastric lymphoma in a patient with AIDS: a case report

Leong

et al. 2021

J Int Med Res

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To the best of our knowledge, there are no previous reports of a gastro-colic fistula (GCF) secondary to primary high-grade B-cell gastric lymphoma associated with acquired immunodeficiency syndrome (AIDS). Here, we report a 37-year-old man who presented with paroxysmal abdominal pain for 4 months, diarrhea for 15 days and weight loss of 4 kg. He had a history of human immunodeficiency virus (HIV) infection and was diagnosed with AIDS in 2013. The patient was diagnosed with a GCF secondary to primary high-grade B-cell gastric lymphoma by gastroscopy and histopathological examination. Two weeks after diagnosis, he died in another hospital. This is an uncommon case in which the GCF occurred secondary to malignant gastric lymphoma in a patient with AIDS. Supported by the literature, patients with HIV infection who complain of abdominal pain or a mass, severe diarrhea, and weight loss should be assessed for a GCF secondary to lymphoma because of its worse prognosis.

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Malignant lymphoma in the HIV‐positive patient

Cited by 36 publications

References 82 publications

Clinical characteristics and outcomes for HIV-associated Diffuse Large B-cell Lymphoma in China: A retrospective single-center study

Clinical characteristics and outcomes for HIV-associated Diffuse Large B-cell Lymphoma in China: A retrospective single-center study

NK/T Lymphoma of Nasal-Type in a Patient with an HIV Infection

A gastro-colic fistula secondary to high-grade B-cell gastric lymphoma in a patient with AIDS: a case report

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