Malignant lymphomas in children in the Netherlands in the period 1973‐1985: Incidence in relation to leukemia: A report from the dutch childhood leukemia study group

Abstract

A retrospective study was done of the incidence of non-Hodgkin's lymphoma (NHL) in children in the Netherlands in the period 1973-85 in relation to that of acute lymphoblastic leukemia (ALL). Complete ascertainment of cases was most likely achieved through the network of cooperating pediatricians of the Dutch Childhood Leukemia Study Group (DCLSG). The incidence of NHL remained constant at 0.75 per 10(5) children per year; the boy/girl ratio was 2.5. In +/- 25% of cases the disease was localized at diagnosis. Of children with NHL who were not listed in the DCLSG leukemia register, 19% had greater than or equal to 25% lymphoblasts in the bone marrow at diagnosis, representing an overlap with ALL of +/- 5%. In 1% of the children with NHL an immuno-deficiency disorder preceded the diagnosis. The incidence of Hodgkin's disease (HD) was 0.3 per 10(5) children per year, with some fluctuation over time, the peak being 0.7 in 1983. The boy/girl ratio was 2.7. Age-specific incidence rates, clinical features of NHL and HD, as well as the ALL to NHL ratio corresponded with those in other European countries and for white children in the USA.

Leukaemia incidence and survival in children and adolescents in Europe during 1978–1997. Report from the Automated Childhood Cancer Information System project

“…Changes in classification might have resulted in some overlap with high-grade non-Hodgkin's lymphomas in case of bulky disease, estimated at approximately 5% of ALL and 20% of non-Hodgkin's lymphoma (NHL) in the Netherlands during the 1980s. 22 However, this probably does not explain the increase in ALL as the incidence rates of other haematopoietic neoplasms also increased in the same populations [Izarzugaza and colleagues, this issue].…”

Childhood NHL in Switzerland: Incidence and Survival of 120 Study and 42 Non‐Study Patients

“…In the UK it was 4.7 [ 131, in Holland 7.4 [14], and in the U.S. 6.9 [15]. We do not know what the reasons for this high incidence are.…”

“…The annual incidence of NHL in Switzerland (8 per lo6 children <15 years of age) is high if compared to other countries. In the UK it was 4.7 [ 131, in Holland 7.4 [14], and in the U.S. 6.9 [15]. We do not know what the reasons for this high incidence are.…”